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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of MXScarna(20) - scored higher in this pairwise comparison

  4. Performance of NanoFolder - scored lower in this pairwise comparison

  5. Compile and download dataset for MXScarna(20) & NanoFolder [.zip] - may take several seconds...


Overview

Metric MXScarna(20) NanoFolder
MCC 0.619 > 0.389
Average MCC ± 95% Confidence Intervals 0.597 ± 0.406 > 0.405 ± 0.473
Sensitivity 0.604 > 0.475
Positive Predictive Value 0.642 > 0.331
Total TP 61 > 48
Total TN 9117 > 9067
Total FP 61 < 114
Total FP CONTRA 10 < 33
Total FP INCONS 24 < 64
Total FP COMP 27 > 17
Total FN 40 < 53
P-value 0.0

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Performance plots


  1. Comparison of performance of MXScarna(20) and NanoFolder. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for MXScarna(20) and NanoFolder).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for MXScarna(20) and NanoFolder. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for MXScarna(20) and NanoFolder).

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Performance of MXScarna(20) - scored higher in this pairwise comparison

1. Total counts & total scores for MXScarna(20)

Total Base Pair Counts
Total TP 61
Total TN 9117
Total FP 61
Total FP CONTRA 10
Total FP INCONS 24
Total FP COMP 27
Total FN 40
Total Scores
MCC 0.619
Average MCC ± 95% Confidence Intervals 0.597 ± 0.406
Sensitivity 0.604
Positive Predictive Value 0.642
Nr of predictions 4

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2. Individual counts for MXScarna(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
4A1C_2 0.22 0.25 0.21 5 4492 36 8 11 17 15
4A1C_3 0.80 0.78 0.83 29 2728 12 0 6 6 8
4AOB_A 0.68 0.69 0.69 20 1408 13 2 7 4 9
4ENC_A 0.68 0.47 1.00 7 489 0 0 0 0 8

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Performance of NanoFolder - scored lower in this pairwise comparison

1. Total counts & total scores for NanoFolder

Total Base Pair Counts
Total TP 48
Total TN 9067
Total FP 114
Total FP CONTRA 33
Total FP INCONS 64
Total FP COMP 17
Total FN 53
Total Scores
MCC 0.389
Average MCC ± 95% Confidence Intervals 0.405 ± 0.473
Sensitivity 0.475
Positive Predictive Value 0.331
Nr of predictions 4

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2. Individual counts for NanoFolder [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
4A1C_2 -0.01 0.00 0.00 0 4469 61 18 29 14 20
4A1C_3 0.58 0.68 0.51 25 2714 24 9 15 0 12
4AOB_A 0.39 0.41 0.39 12 1406 20 4 15 1 17
4ENC_A 0.66 0.73 0.61 11 478 9 2 5 2 4

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.