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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of CentroidAlifold(20) - scored higher in this pairwise comparison

  4. Performance of PETfold_pre2.0(20) - scored lower in this pairwise comparison

  5. Compile and download dataset for CentroidAlifold(20) & PETfold_pre2.0(20) [.zip] - may take several seconds...


Overview

Metric CentroidAlifold(20) PETfold_pre2.0(20)
MCC 0.698 > 0.619
Average MCC ± 95% Confidence Intervals 0.668 ± 0.379 > 0.603 ± 0.416
Sensitivity 0.557 < 0.570
Positive Predictive Value 0.880 > 0.682
Total TP 44 < 45
Total TN 6871 > 6855
Total FP 10 < 33
Total FP CONTRA 3 > 2
Total FP INCONS 3 < 19
Total FP COMP 4 < 12
Total FN 35 > 34
P-value 0.0

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Performance plots


  1. Comparison of performance of CentroidAlifold(20) and PETfold_pre2.0(20). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for CentroidAlifold(20) and PETfold_pre2.0(20)).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for CentroidAlifold(20) and PETfold_pre2.0(20). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for CentroidAlifold(20) and PETfold_pre2.0(20)).

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Performance of CentroidAlifold(20) - scored higher in this pairwise comparison

1. Total counts & total scores for CentroidAlifold(20)

Total Base Pair Counts
Total TP 44
Total TN 6871
Total FP 10
Total FP CONTRA 3
Total FP INCONS 3
Total FP COMP 4
Total FN 35
Total Scores
MCC 0.698
Average MCC ± 95% Confidence Intervals 0.668 ± 0.379
Sensitivity 0.557
Positive Predictive Value 0.880
Nr of predictions 4

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2. Individual counts for CentroidAlifold(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
4A1C_2 0.33 0.25 0.45 5 4505 8 3 3 2 15
4AOB_A 0.89 0.79 1.00 23 1414 2 0 0 2 6
4ENB_A 0.77 0.60 1.00 9 463 0 0 0 0 6
4ENC_A 0.68 0.47 1.00 7 489 0 0 0 0 8

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Performance of PETfold_pre2.0(20) - scored lower in this pairwise comparison

1. Total counts & total scores for PETfold_pre2.0(20)

Total Base Pair Counts
Total TP 45
Total TN 6855
Total FP 33
Total FP CONTRA 2
Total FP INCONS 19
Total FP COMP 12
Total FN 34
Total Scores
MCC 0.619
Average MCC ± 95% Confidence Intervals 0.603 ± 0.416
Sensitivity 0.570
Positive Predictive Value 0.682
Nr of predictions 4

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2. Individual counts for PETfold_pre2.0(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
4A1C_2 0.25 0.25 0.25 5 4496 25 2 13 10 15
4AOB_A 0.87 0.83 0.92 24 1411 4 0 2 2 5
4ENB_A 0.68 0.53 0.89 8 463 1 0 1 0 7
4ENC_A 0.61 0.53 0.73 8 485 3 0 3 0 7

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.