CompaRNA - on-line benchmarks of RNA structure prediction methods

Laboratory of Structural Bioinformatics @ Adam Mickiewicz University in Poznan

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Overview

Metric	RNASampler(20)		McQFold
MCC	0.565	>	0.388
Average MCC ± 95% Confidence Intervals	0.539 ± 0.043	>	0.387 ± 0.037
Sensitivity	0.413	>	0.377
Positive Predictive Value	0.772	>	0.401
Total TP	3079	>	2810
Total TN	4282091	>	4279076
Total FP	1146	<	4493
Total FP CONTRA	258	<	629
Total FP INCONS	649	<	3562
Total FP COMP	239	<	302
Total FN	4370	<	4639
P-value	3.56938820447e-08

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Performance plots

Comparison of performance of RNASampler(20) and McQFold. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for RNASampler(20) and McQFold).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for RNASampler(20) and McQFold).
Comparison of average Matthews Correlation Coefficients (MCCs) for RNASampler(20) and McQFold. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for RNASampler(20) and McQFold).

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Performance of RNASampler(20) - scored higher in this pairwise comparison

1. Total counts & total scores for RNASampler(20)

Total Base Pair Counts
Total TP	3079
Total TN	4282091
Total FP	1146
Total FP CONTRA	258
Total FP INCONS	649
Total FP COMP	239
Total FN	4370

Total Scores
MCC	0.565
Average MCC ± 95% Confidence Intervals	0.539 ± 0.043
Sensitivity	0.413
Positive Predictive Value	0.772
Nr of predictions	78

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2. Individual counts for RNASampler(20) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
ASE_00064	RNaseP_bact_a links to Rfam database...	0.44	0.34	0.58	30	45399	23	1	21	1	59
ASE_00090	RNaseP_bact_a links to Rfam database...	0.54	0.40	0.74	40	55557	14	0	14	0	61
ASE_00135	RNaseP_bact_a links to Rfam database...	0.54	0.36	0.83	39	63143	16	0	8	8	70
ASE_00153	RNaseP_nuc links to Rfam database...	0.38	0.33	0.44	24	57576	38	7	23	8	49
ASE_00215	RNaseP_bact_a links to Rfam database...	0.38	0.23	0.62	23	48479	16	0	14	2	76
ASE_00305	RNaseP_bact_b links to Rfam database...	0.78	0.71	0.86	60	54545	14	1	9	4	25
ASE_00328	RNaseP_bact_b links to Rfam database...	0.70	0.57	0.85	64	72696	14	5	6	3	48
ASE_00361	RNaseP_bact_a links to Rfam database...	0.34	0.21	0.55	27	75417	26	3	19	4	100
ASE_00427	RNaseP_nuc links to Rfam database...	0.57	0.46	0.72	21	40726	18	1	7	10	25
ASE_00441	RNaseP_bact_a links to Rfam database...	0.46	0.31	0.69	35	64210	16	0	16	0	77
SRP_00006	Metazoa_SRP links to Rfam database...	0.87	0.76	0.99	77	45675	4	0	1	3	24
SRP_00011	Plant_SRP links to Rfam database...	0.55	0.42	0.71	44	46298	18	4	14	0	60
SRP_00015	Plant_SRP links to Rfam database...	0.74	0.59	0.94	58	46298	5	3	1	1	41
SRP_00024	Bacteria_large_SRP links to Rfam database...	0.28	0.08	1.00	7	37668	0	0	0	0	80
SRP_00026	Bacteria_large_SRP links to Rfam database...	0.51	0.27	0.96	24	36831	1	0	1	0	64
SRP_00030	Bacteria_large_SRP links to Rfam database...	0.28	0.08	1.00	7	36849	0	0	0	0	81
SRP_00031	Bacteria_large_SRP links to Rfam database...	0.35	0.12	1.00	11	36304	0	0	0	0	78
SRP_00037	Bacteria_large_SRP links to Rfam database...	0.00	0.00	0.00	0	36585	0	0	0	0	87
SRP_00050	Metazoa_SRP links to Rfam database...	0.86	0.76	0.99	75	44774	3	0	1	2	24
SRP_00066	Metazoa_SRP links to Rfam database...	0.81	0.66	0.99	66	45384	1	0	1	0	34
SRP_00086	Metazoa_SRP links to Rfam database...	0.87	0.77	0.99	77	44175	3	0	1	2	23
SRP_00088	Bacteria_large_SRP links to Rfam database...	0.40	0.16	1.00	14	34177	0	0	0	0	75
SRP_00089	Bacteria_large_SRP links to Rfam database...	0.00	0.00	0.00	0	35778	0	0	0	0	90
SRP_00090	Bacteria_large_SRP links to Rfam database...	0.00	0.00	0.00	0	35511	0	0	0	0	90
SRP_00102	Metazoa_SRP links to Rfam database...	0.86	0.77	0.95	78	44469	4	0	4	0	23
SRP_00103	Metazoa_SRP links to Rfam database...	0.80	0.64	1.00	65	45386	0	0	0	0	37
SRP_00152	Plant_SRP links to Rfam database...	0.52	0.27	1.00	28	45725	0	0	0	0	75
SRP_00171	Metazoa_SRP links to Rfam database...	0.74	0.61	0.89	54	45390	7	2	5	0	34
SRP_00178	Plant_SRP links to Rfam database...	0.36	0.13	1.00	13	45740	0	0	0	0	89
SRP_00179	Plant_SRP links to Rfam database...	0.39	0.16	0.94	17	46038	1	0	1	0	88
SRP_00181	Plant_SRP links to Rfam database...	0.41	0.17	1.00	17	46039	0	0	0	0	85
SRP_00182	Plant_SRP links to Rfam database...	0.78	0.66	0.92	67	45983	6	0	6	0	34
SRP_00188	Plant_SRP links to Rfam database...	0.26	0.14	0.48	11	31102	12	1	11	0	68
SRP_00228	Metazoa_SRP links to Rfam database...	0.88	0.78	0.99	74	45376	7	0	1	6	21
SRP_00234	Bacteria_large_SRP links to Rfam database...	0.47	0.23	0.95	20	36294	1	0	1	0	66
SRP_00308	Bacteria_large_SRP links to Rfam database...	0.28	0.08	1.00	7	36308	0	0	0	0	81
SRP_00317	Metazoa_SRP links to Rfam database...	0.76	0.61	0.95	60	45087	8	0	3	5	38
SRP_00335	Bacteria_large_SRP links to Rfam database...	0.42	0.18	1.00	7	35238	0	0	0	0	32
SRP_00337	Bacteria_large_SRP links to Rfam database...	0.38	0.14	1.00	13	35498	0	0	0	0	78
SRP_00347	Metazoa_SRP links to Rfam database...	0.80	0.66	0.98	63	46601	5	0	1	4	33
SRP_00368	Metazoa_SRP links to Rfam database...	0.77	0.59	1.00	58	43898	2	0	0	2	40
TMR_00017	tmRNA links to Rfam database...	0.60	0.45	0.81	46	67104	15	2	9	4	56
TMR_00018	tmRNA links to Rfam database...	0.52	0.41	0.64	38	64561	25	10	11	4	54
TMR_00042	tmRNA links to Rfam database...	0.60	0.42	0.85	41	62787	13	0	7	6	57
TMR_00046	tmRNA links to Rfam database...	0.48	0.40	0.58	38	62769	34	5	23	6	58
TMR_00048	tmRNA links to Rfam database...	0.61	0.46	0.80	44	64925	16	3	8	5	51
TMR_00080	tmRNA links to Rfam database...	0.49	0.41	0.60	39	70435	28	10	16	2	57
TMR_00082	tmRNA links to Rfam database...	0.43	0.31	0.59	30	67845	21	13	8	0	66
TMR_00123	tmRNA links to Rfam database...	0.60	0.46	0.79	46	66372	17	3	9	5	55
TMR_00137	tmRNA links to Rfam database...	0.47	0.37	0.59	33	61019	28	11	12	5	56
TMR_00142	tmRNA links to Rfam database...	0.56	0.47	0.67	48	70804	31	9	15	7	54
TMR_00207	tmRNA links to Rfam database...	0.52	0.39	0.70	40	72333	21	4	13	4	63
TMR_00257	tmRNA links to Rfam database...	0.56	0.40	0.78	39	67111	16	3	8	5	59
TMR_00271	tmRNA links to Rfam database...	0.48	0.34	0.69	31	64216	21	7	7	7	60
TMR_00332	tmRNA links to Rfam database...	0.52	0.41	0.66	41	67099	22	6	15	1	58
TMR_00366	tmRNA links to Rfam database...	0.55	0.46	0.65	46	67825	36	12	13	11	54
TMR_00378	tmRNA links to Rfam database...	0.55	0.46	0.65	45	67827	35	8	16	11	52
TMR_00404	tmRNA links to Rfam database...	0.66	0.54	0.81	50	67466	20	4	8	8	42
TMR_00427	tmRNA links to Rfam database...	0.47	0.34	0.65	33	67477	20	7	11	2	64
TMR_00443	tmRNA links to Rfam database...	0.56	0.41	0.75	43	67104	14	6	8	0	61
TMR_00451	tmRNA links to Rfam database...	0.34	0.25	0.47	22	63499	29	10	15	4	67
TMR_00458	tmRNA links to Rfam database...	0.55	0.42	0.72	39	63492	15	7	8	0	54
TMR_00469	tmRNA links to Rfam database...	0.72	0.61	0.86	61	64549	11	4	6	1	39
TMR_00472	tmRNA links to Rfam database...	0.75	0.63	0.88	61	64551	13	2	6	5	36
TMR_00519	tmRNA links to Rfam database...	0.50	0.40	0.62	38	63129	27	14	9	4	57
TMR_00520	tmRNA links to Rfam database...	0.40	0.31	0.52	31	63130	33	12	17	4	68
TMR_00522	tmRNA links to Rfam database...	0.54	0.42	0.68	41	63130	24	9	10	5	56
TMR_00528	tmRNA links to Rfam database...	0.49	0.40	0.59	39	63124	31	12	15	4	58
TMR_00540	tmRNA links to Rfam database...	0.47	0.37	0.59	38	73472	26	10	16	0	66
TMR_00568	tmRNA links to Rfam database...	0.72	0.66	0.78	65	60643	26	2	16	8	34
TMR_00571	tmRNA links to Rfam database...	0.77	0.71	0.83	70	60642	22	2	12	8	29
TMR_00580	tmRNA links to Rfam database...	0.53	0.47	0.59	47	60647	40	3	29	8	53
TMR_00584	tmRNA links to Rfam database...	0.71	0.65	0.79	63	60995	25	3	14	8	34
TMR_00586	tmRNA links to Rfam database...	0.61	0.52	0.72	50	61006	26	5	14	7	47
TMR_00616	tmRNA links to Rfam database...	0.66	0.57	0.77	56	67088	23	3	14	6	43
TMR_00699	tmRNA links to Rfam database...	0.54	0.38	0.76	39	67110	13	3	9	1	63
TMR_00702	tmRNA links to Rfam database...	0.42	0.32	0.56	32	67104	28	3	22	3	68
TMR_00703	tmRNA links to Rfam database...	0.56	0.41	0.76	41	67474	18	3	10	5	58

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Performance of McQFold - scored lower in this pairwise comparison

1. Total counts & total scores for McQFold

Total Base Pair Counts
Total TP	2810
Total TN	4279076
Total FP	4493
Total FP CONTRA	629
Total FP INCONS	3562
Total FP COMP	302
Total FN	4639

Total Scores
MCC	0.388
Average MCC ± 95% Confidence Intervals	0.387 ± 0.037
Sensitivity	0.377
Positive Predictive Value	0.401
Nr of predictions	78

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2. Individual counts for McQFold [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
ASE_00064	RNaseP_bact_a links to Rfam database...	0.50	0.49	0.51	44	45364	46	5	38	3	45
ASE_00090	RNaseP_bact_a links to Rfam database...	0.52	0.52	0.52	53	55510	52	6	42	4	48
ASE_00135	RNaseP_bact_a links to Rfam database...	0.30	0.28	0.31	31	63090	74	3	66	5	78
ASE_00153	RNaseP_nuc links to Rfam database...	0.51	0.53	0.49	39	57550	72	9	32	31	34
ASE_00215	RNaseP_bact_a links to Rfam database...	0.30	0.28	0.32	28	48429	60	7	52	1	71
ASE_00305	RNaseP_bact_b links to Rfam database...	0.64	0.67	0.62	57	54523	44	7	28	9	28
ASE_00328	RNaseP_bact_b links to Rfam database...	0.61	0.60	0.63	67	72665	47	2	37	8	45
ASE_00361	RNaseP_bact_a links to Rfam database...	0.43	0.40	0.47	51	75358	59	8	49	2	76
ASE_00427	RNaseP_nuc links to Rfam database...	0.11	0.13	0.09	6	40688	71	32	29	10	40
ASE_00441	RNaseP_bact_a links to Rfam database...	0.73	0.65	0.81	73	64171	21	6	11	4	39
SRP_00006	Metazoa_SRP links to Rfam database...	0.14	0.13	0.15	13	45669	73	3	68	2	88
SRP_00011	Plant_SRP links to Rfam database...	0.29	0.26	0.32	27	46276	57	2	55	0	77
SRP_00015	Plant_SRP links to Rfam database...	0.52	0.48	0.56	48	46274	39	0	38	1	51
SRP_00024	Bacteria_large_SRP links to Rfam database...	0.48	0.46	0.51	40	37596	40	2	37	1	47
SRP_00026	Bacteria_large_SRP links to Rfam database...	0.45	0.42	0.47	37	36778	46	2	39	5	51
SRP_00030	Bacteria_large_SRP links to Rfam database...	0.40	0.38	0.43	33	36780	44	6	37	1	55
SRP_00031	Bacteria_large_SRP links to Rfam database...	0.40	0.38	0.43	34	36236	45	2	43	0	55
SRP_00037	Bacteria_large_SRP links to Rfam database...	0.33	0.30	0.36	26	36513	46	4	42	0	61
SRP_00050	Metazoa_SRP links to Rfam database...	0.52	0.49	0.55	49	44761	40	4	36	0	50
SRP_00066	Metazoa_SRP links to Rfam database...	0.00	0.00	0.00	0	45360	91	8	83	0	100
SRP_00086	Metazoa_SRP links to Rfam database...	0.70	0.64	0.77	64	44170	21	1	18	2	36
SRP_00088	Bacteria_large_SRP links to Rfam database...	0.53	0.52	0.54	46	34106	39	4	35	0	43
SRP_00089	Bacteria_large_SRP links to Rfam database...	0.76	0.70	0.82	63	35701	14	1	13	0	27
SRP_00090	Bacteria_large_SRP links to Rfam database...	0.18	0.17	0.21	15	35439	58	7	50	1	75
SRP_00102	Metazoa_SRP links to Rfam database...	0.32	0.31	0.34	31	44460	60	6	54	0	70
SRP_00103	Metazoa_SRP links to Rfam database...	0.05	0.05	0.06	5	45362	84	7	77	0	97
SRP_00152	Plant_SRP links to Rfam database...	0.44	0.44	0.45	45	45654	54	11	43	0	58
SRP_00171	Metazoa_SRP links to Rfam database...	0.21	0.20	0.22	18	45368	65	8	57	0	70
SRP_00178	Plant_SRP links to Rfam database...	0.19	0.18	0.21	18	45666	69	8	61	0	84
SRP_00179	Plant_SRP links to Rfam database...	0.46	0.43	0.51	45	45967	47	6	38	3	60
SRP_00181	Plant_SRP links to Rfam database...	0.19	0.18	0.20	18	45968	70	1	69	0	84
SRP_00182	Plant_SRP links to Rfam database...	0.70	0.69	0.71	70	45957	32	7	22	3	31
SRP_00188	Plant_SRP links to Rfam database...	0.18	0.18	0.18	14	31046	65	10	55	0	65
SRP_00228	Metazoa_SRP links to Rfam database...	0.41	0.38	0.46	36	45372	45	2	41	2	59
SRP_00234	Bacteria_large_SRP links to Rfam database...	0.34	0.34	0.34	29	36230	60	5	51	4	57
SRP_00308	Bacteria_large_SRP links to Rfam database...	0.45	0.42	0.48	37	36238	40	5	35	0	51
SRP_00317	Metazoa_SRP links to Rfam database...	0.57	0.52	0.63	51	45069	32	1	29	2	47
SRP_00335	Bacteria_large_SRP links to Rfam database...	0.19	0.26	0.15	10	35178	77	23	34	20	29
SRP_00337	Bacteria_large_SRP links to Rfam database...	0.81	0.78	0.85	71	35427	14	1	12	1	20
SRP_00347	Metazoa_SRP links to Rfam database...	0.31	0.30	0.32	29	46575	64	8	53	3	67
SRP_00368	Metazoa_SRP links to Rfam database...	0.42	0.40	0.45	39	43869	50	7	41	2	59
TMR_00017	tmRNA links to Rfam database...	0.25	0.24	0.26	24	67070	73	5	62	6	78
TMR_00018	tmRNA links to Rfam database...	0.56	0.59	0.54	54	64520	48	15	31	2	38
TMR_00042	tmRNA links to Rfam database...	0.16	0.15	0.16	15	62744	81	8	68	5	83
TMR_00046	tmRNA links to Rfam database...	0.28	0.29	0.26	28	62729	78	15	63	0	68
TMR_00048	tmRNA links to Rfam database...	0.31	0.33	0.30	31	64876	75	16	57	2	64
TMR_00080	tmRNA links to Rfam database...	0.45	0.46	0.44	44	70400	57	19	37	1	52
TMR_00082	tmRNA links to Rfam database...	0.50	0.49	0.52	47	67805	48	11	33	4	49
TMR_00123	tmRNA links to Rfam database...	0.26	0.25	0.27	25	66338	71	4	63	4	76
TMR_00137	tmRNA links to Rfam database...	0.39	0.36	0.43	32	61000	48	8	35	5	57
TMR_00142	tmRNA links to Rfam database...	0.54	0.53	0.55	54	70778	56	10	34	12	48
TMR_00207	tmRNA links to Rfam database...	0.25	0.24	0.25	25	72291	81	7	67	7	78
TMR_00257	tmRNA links to Rfam database...	0.24	0.22	0.25	22	67073	67	13	53	1	76
TMR_00271	tmRNA links to Rfam database...	0.44	0.45	0.44	41	64168	61	6	46	9	50
TMR_00332	tmRNA links to Rfam database...	0.51	0.48	0.55	48	67073	45	7	33	5	51
TMR_00366	tmRNA links to Rfam database...	0.50	0.51	0.50	51	67794	55	15	36	4	49
TMR_00378	tmRNA links to Rfam database...	0.43	0.44	0.42	43	67793	60	13	47	0	54
TMR_00404	tmRNA links to Rfam database...	0.42	0.46	0.39	42	67419	67	21	46	0	50
TMR_00427	tmRNA links to Rfam database...	0.33	0.31	0.36	30	67445	60	9	44	7	67
TMR_00443	tmRNA links to Rfam database...	0.52	0.48	0.56	50	67071	42	9	31	2	54
TMR_00451	tmRNA links to Rfam database...	0.21	0.22	0.20	20	63448	82	16	62	4	69
TMR_00458	tmRNA links to Rfam database...	0.37	0.34	0.40	32	63465	53	15	34	4	61
TMR_00469	tmRNA links to Rfam database...	0.35	0.34	0.35	34	64524	67	5	57	5	66
TMR_00472	tmRNA links to Rfam database...	0.23	0.24	0.23	23	64519	86	16	62	8	74
TMR_00519	tmRNA links to Rfam database...	0.25	0.25	0.24	24	63091	77	12	63	2	71
TMR_00520	tmRNA links to Rfam database...	0.35	0.33	0.37	33	63100	66	11	46	9	66
TMR_00522	tmRNA links to Rfam database...	0.37	0.36	0.39	35	63100	62	5	50	7	62
TMR_00528	tmRNA links to Rfam database...	0.46	0.44	0.48	43	63100	58	12	35	11	54
TMR_00540	tmRNA links to Rfam database...	0.10	0.11	0.11	11	73432	101	12	81	8	93
TMR_00568	tmRNA links to Rfam database...	0.35	0.33	0.37	33	60637	62	7	49	6	66
TMR_00571	tmRNA links to Rfam database...	0.43	0.41	0.45	41	60635	57	9	41	7	58
TMR_00580	tmRNA links to Rfam database...	0.46	0.43	0.49	43	60638	48	5	40	3	57
TMR_00584	tmRNA links to Rfam database...	0.58	0.55	0.61	53	60988	42	5	29	8	44
TMR_00586	tmRNA links to Rfam database...	0.42	0.39	0.44	38	60989	53	9	39	5	59
TMR_00616	tmRNA links to Rfam database...	0.26	0.26	0.26	26	67061	78	9	65	4	73
TMR_00699	tmRNA links to Rfam database...	0.41	0.41	0.41	42	67059	60	11	49	0	60
TMR_00702	tmRNA links to Rfam database...	0.25	0.26	0.25	26	67055	83	7	73	3	74
TMR_00703	tmRNA links to Rfam database...	0.38	0.37	0.40	37	67435	58	5	51	2	62

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.

Table of contents:

Overview

Performance plots

Performance of RNASampler(20) - scored higher in this pairwise comparison

1. Total counts & total scores for RNASampler(20)

2. Individual counts for RNASampler(20) [ download as .csv ]

Performance of McQFold - scored lower in this pairwise comparison

1. Total counts & total scores for McQFold

2. Individual counts for McQFold [ download as .csv ]