CompaRNA - on-line benchmarks of RNA structure prediction methods

Laboratory of Structural Bioinformatics @ Adam Mickiewicz University in Poznan

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Overview

Metric	RNAalifold(20)		NanoFolder
MCC	0.662	>	0.150
Average MCC ± 95% Confidence Intervals	0.662 ± 0.029	>	0.148 ± 0.028
Sensitivity	0.538	>	0.173
Positive Predictive Value	0.817	>	0.133
Total TP	3148	>	1011
Total TN	3288959	>	3285186
Total FP	818	<	6745
Total FP CONTRA	124	<	932
Total FP INCONS	580	<	5682
Total FP COMP	114	<	131
Total FN	2706	<	4843
P-value	3.56938820447e-08

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Performance plots

Comparison of performance of RNAalifold(20) and NanoFolder. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for RNAalifold(20) and NanoFolder).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for RNAalifold(20) and NanoFolder).
Comparison of average Matthews Correlation Coefficients (MCCs) for RNAalifold(20) and NanoFolder. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for RNAalifold(20) and NanoFolder).

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Performance of RNAalifold(20) - scored higher in this pairwise comparison

1. Total counts & total scores for RNAalifold(20)

Total Base Pair Counts
Total TP	3148
Total TN	3288959
Total FP	818
Total FP CONTRA	124
Total FP INCONS	580
Total FP COMP	114
Total FN	2706

Total Scores
MCC	0.662
Average MCC ± 95% Confidence Intervals	0.662 ± 0.029
Sensitivity	0.538
Positive Predictive Value	0.817
Nr of predictions	57

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2. Individual counts for RNAalifold(20) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
ASE_00083	RNaseP_bact_a links to Rfam database...	0.77	0.62	0.96	68	62410	4	2	1	1	42
ASE_00185	RNaseP_bact_a links to Rfam database...	0.70	0.51	0.97	65	73469	2	1	1	0	63
ASE_00190	RNaseP_bact_b links to Rfam database...	0.64	0.52	0.78	47	45391	17	0	13	4	43
ASE_00221	RNaseP_bact_a links to Rfam database...	0.78	0.68	0.89	80	64530	10	1	9	0	37
ASE_00228	RNaseP_bact_a links to Rfam database...	0.70	0.62	0.79	53	46904	15	5	9	1	33
ASE_00229	RNaseP_bact_a links to Rfam database...	0.74	0.61	0.90	53	42427	8	0	6	2	34
ASE_00231	RNaseP_bact_a links to Rfam database...	0.59	0.46	0.76	44	47837	18	0	14	4	52
ASE_00234	RNaseP_bact_a links to Rfam database...	0.50	0.32	0.77	41	75413	12	3	9	0	88
ASE_00238	RNaseP_bact_a links to Rfam database...	0.59	0.46	0.78	52	64194	16	0	15	1	62
ASE_00248	RNaseP_bact_a links to Rfam database...	0.73	0.62	0.87	71	62399	11	3	8	0	43
ASE_00254	RNaseP_bact_a links to Rfam database...	0.79	0.68	0.92	56	36795	6	0	5	1	26
ASE_00255	RNaseP_bact_a links to Rfam database...	0.49	0.40	0.60	52	74605	35	1	33	1	78
ASE_00257	RNaseP_bact_a links to Rfam database...	0.62	0.52	0.75	50	50973	17	3	14	0	47
ASE_00267	RNaseP_bact_a links to Rfam database...	0.82	0.75	0.89	66	45076	9	3	5	1	22
ASE_00270	RNaseP_bact_a links to Rfam database...	0.30	0.18	0.50	23	72344	25	1	22	2	105
ASE_00274	RNaseP_bact_a links to Rfam database...	0.50	0.36	0.69	37	55557	17	5	12	0	66
ASE_00277	RNaseP_bact_a links to Rfam database...	0.48	0.37	0.62	34	48150	21	4	17	0	57
ASE_00279	RNaseP_bact_a links to Rfam database...	0.74	0.60	0.91	61	53234	6	0	6	0	40
ASE_00285	RNaseP_bact_a links to Rfam database...	0.63	0.48	0.84	58	68937	11	2	9	0	64
ASE_00287	RNaseP_bact_a links to Rfam database...	0.63	0.48	0.84	49	54888	9	1	8	0	54
ASE_00294	RNaseP_bact_a links to Rfam database...	0.64	0.47	0.87	81	114388	14	2	10	2	90
ASE_00298	RNaseP_bact_a links to Rfam database...	0.65	0.51	0.83	58	67458	12	5	7	0	55
ASE_00318	RNaseP_bact_b links to Rfam database...	0.74	0.60	0.91	71	80122	17	2	5	10	47
ASE_00321	RNaseP_bact_b links to Rfam database...	0.81	0.74	0.88	65	54541	20	1	8	11	23
ASE_00335	RNaseP_bact_b links to Rfam database...	0.70	0.62	0.80	72	75376	24	5	13	6	44
ASE_00340	RNaseP_bact_a links to Rfam database...	0.65	0.55	0.76	47	45994	15	7	8	0	38
ASE_00367	RNaseP_bact_a links to Rfam database...	0.78	0.65	0.93	56	43011	4	0	4	0	30
ASE_00370	RNaseP_bact_a links to Rfam database...	0.66	0.51	0.84	43	41854	8	0	8	0	41
ASE_00372	RNaseP_bact_a links to Rfam database...	0.74	0.62	0.87	62	51932	9	0	9	0	38
ASE_00376	RNaseP_bact_a links to Rfam database...	0.73	0.58	0.92	61	56887	6	0	5	1	44
ASE_00377	RNaseP_bact_a links to Rfam database...	0.73	0.59	0.90	63	57560	7	0	7	0	44
ASE_00386	RNaseP_bact_a links to Rfam database...	0.75	0.64	0.90	61	50335	7	2	5	0	35
ASE_00393	RNaseP_bact_a links to Rfam database...	0.67	0.58	0.78	54	47826	16	2	13	1	39
ASE_00412	RNaseP_bact_a links to Rfam database...	0.61	0.49	0.76	51	58244	20	0	16	4	54
ASE_00413	RNaseP_bact_a links to Rfam database...	0.60	0.52	0.70	42	44491	21	4	14	3	39
ASE_00416	RNaseP_bact_a links to Rfam database...	0.70	0.60	0.83	76	77329	16	2	14	0	51
ASE_00422	RNaseP_bact_a links to Rfam database...	0.69	0.59	0.82	55	46904	13	0	12	1	39
ASE_00427	RNaseP_nuc links to Rfam database...	0.69	0.65	0.73	30	40714	23	4	7	12	16
ASE_00428	RNaseP_bact_a links to Rfam database...	0.66	0.54	0.80	68	76551	17	1	16	0	57
ASE_00430	RNaseP_bact_a links to Rfam database...	0.69	0.57	0.83	55	46905	12	0	11	1	42
ASE_00437	RNaseP_bact_a links to Rfam database...	0.45	0.36	0.58	48	79318	35	2	33	0	87
ASE_00451	RNaseP_bact_a links to Rfam database...	0.70	0.56	0.86	70	70795	11	3	8	0	55
SRP_00103	Metazoa_SRP links to Rfam database...	0.76	0.66	0.87	67	45374	12	1	9	2	35
SRP_00173	Bacteria_large_SRP links to Rfam database...	0.55	0.36	0.86	32	38189	6	0	5	1	58
SRP_00234	Bacteria_large_SRP links to Rfam database...	0.54	0.33	0.90	28	36284	4	0	3	1	58
SRP_00308	Bacteria_large_SRP links to Rfam database...	0.48	0.32	0.74	28	36277	10	4	6	0	60
SRP_00317	Metazoa_SRP links to Rfam database...	0.91	0.85	0.98	83	45065	7	0	2	5	15
SRP_00337	Bacteria_large_SRP links to Rfam database...	0.70	0.53	0.94	48	35460	4	0	3	1	43
TMR_00123	tmRNA links to Rfam database...	0.70	0.55	0.89	56	66367	12	1	6	5	45
TMR_00399	tmRNA links to Rfam database...	0.63	0.56	0.70	53	64904	27	6	17	4	41
TMR_00443	tmRNA links to Rfam database...	0.73	0.63	0.86	65	67085	15	6	5	4	39
TMR_00469	tmRNA links to Rfam database...	0.70	0.60	0.81	60	64546	14	7	7	0	40
TMR_00519	tmRNA links to Rfam database...	0.57	0.48	0.67	46	63121	25	7	16	2	49
TMR_00528	tmRNA links to Rfam database...	0.54	0.47	0.62	46	63116	34	9	19	6	51
TMR_00571	tmRNA links to Rfam database...	0.75	0.69	0.83	68	60644	20	3	11	6	31
TMR_00584	tmRNA links to Rfam database...	0.75	0.68	0.83	66	60995	17	2	12	3	31
TMR_00703	tmRNA links to Rfam database...	0.67	0.54	0.83	53	67464	15	1	10	4	46

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Performance of NanoFolder - scored lower in this pairwise comparison

1. Total counts & total scores for NanoFolder

Total Base Pair Counts
Total TP	1011
Total TN	3285186
Total FP	6745
Total FP CONTRA	932
Total FP INCONS	5682
Total FP COMP	131
Total FN	4843

Total Scores
MCC	0.150
Average MCC ± 95% Confidence Intervals	0.148 ± 0.028
Sensitivity	0.173
Positive Predictive Value	0.133
Nr of predictions	57

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2. Individual counts for NanoFolder [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
ASE_00083	RNaseP_bact_a links to Rfam database...	0.22	0.25	0.20	27	62347	108	12	95	1	83
ASE_00185	RNaseP_bact_a links to Rfam database...	0.17	0.19	0.16	24	73382	134	14	116	4	104
ASE_00190	RNaseP_bact_b links to Rfam database...	0.24	0.28	0.21	25	45334	93	14	78	1	65
ASE_00221	RNaseP_bact_a links to Rfam database...	0.20	0.21	0.18	25	64484	112	10	101	1	92
ASE_00228	RNaseP_bact_a links to Rfam database...	0.05	0.06	0.04	5	46858	109	17	91	1	81
ASE_00229	RNaseP_bact_a links to Rfam database...	0.12	0.14	0.11	12	42380	97	12	82	3	75
ASE_00231	RNaseP_bact_a links to Rfam database...	0.37	0.42	0.33	40	47773	84	17	65	2	56
ASE_00234	RNaseP_bact_a links to Rfam database...	0.25	0.27	0.23	35	75315	117	10	106	1	94
ASE_00238	RNaseP_bact_a links to Rfam database...	0.26	0.30	0.23	34	64111	119	18	98	3	80
ASE_00248	RNaseP_bact_a links to Rfam database...	0.13	0.15	0.12	17	62340	124	9	115	0	97
ASE_00254	RNaseP_bact_a links to Rfam database...	0.15	0.16	0.14	13	36761	88	3	79	6	69
ASE_00255	RNaseP_bact_a links to Rfam database...	0.11	0.12	0.10	16	74530	146	16	129	1	114
ASE_00257	RNaseP_bact_a links to Rfam database...	0.37	0.42	0.33	41	50917	85	15	67	3	56
ASE_00267	RNaseP_bact_a links to Rfam database...	0.00	0.00	0.00	0	45036	115	9	105	1	88
ASE_00270	RNaseP_bact_a links to Rfam database...	0.19	0.21	0.17	27	72232	132	14	117	1	101
ASE_00274	RNaseP_bact_a links to Rfam database...	0.00	0.00	0.00	0	55487	126	12	112	2	103
ASE_00277	RNaseP_bact_a links to Rfam database...	0.10	0.12	0.08	11	48071	123	23	100	0	80
ASE_00279	RNaseP_bact_a links to Rfam database...	0.14	0.16	0.13	16	53177	109	16	92	1	85
ASE_00285	RNaseP_bact_a links to Rfam database...	0.34	0.36	0.31	44	68866	98	14	82	2	78
ASE_00287	RNaseP_bact_a links to Rfam database...	0.15	0.17	0.14	17	54824	107	14	91	2	86
ASE_00294	RNaseP_bact_a links to Rfam database...	0.12	0.13	0.12	23	114287	172	11	160	1	148
ASE_00298	RNaseP_bact_a links to Rfam database...	0.09	0.10	0.08	11	67389	129	8	120	1	102
ASE_00318	RNaseP_bact_b links to Rfam database...	0.03	0.04	0.03	5	80039	156	21	135	0	113
ASE_00321	RNaseP_bact_b links to Rfam database...	0.11	0.14	0.09	12	54484	122	22	97	3	76
ASE_00335	RNaseP_bact_b links to Rfam database...	0.10	0.12	0.09	14	75304	151	22	126	3	102
ASE_00340	RNaseP_bact_a links to Rfam database...	0.06	0.07	0.05	6	45943	110	13	94	3	79
ASE_00367	RNaseP_bact_a links to Rfam database...	0.08	0.09	0.07	8	42960	110	10	93	7	78
ASE_00370	RNaseP_bact_a links to Rfam database...	0.03	0.04	0.03	3	41796	109	18	88	3	81
ASE_00372	RNaseP_bact_a links to Rfam database...	0.17	0.20	0.15	20	51871	113	19	93	1	80
ASE_00376	RNaseP_bact_a links to Rfam database...	0.00	0.00	0.00	0	56822	136	9	122	5	105
ASE_00377	RNaseP_bact_a links to Rfam database...	0.25	0.27	0.23	29	57505	98	10	86	2	78
ASE_00386	RNaseP_bact_a links to Rfam database...	0.14	0.16	0.13	15	50284	106	9	95	2	81
ASE_00393	RNaseP_bact_a links to Rfam database...	0.31	0.35	0.27	33	47773	90	18	71	1	60
ASE_00412	RNaseP_bact_a links to Rfam database...	0.15	0.17	0.14	18	58183	111	14	96	1	87
ASE_00413	RNaseP_bact_a links to Rfam database...	0.08	0.10	0.07	8	44438	108	19	86	3	73
ASE_00416	RNaseP_bact_a links to Rfam database...	0.39	0.43	0.35	54	77267	103	18	82	3	73
ASE_00422	RNaseP_bact_a links to Rfam database...	0.28	0.31	0.25	29	46856	87	9	77	1	65
ASE_00427	RNaseP_nuc links to Rfam database...	0.06	0.09	0.04	4	40651	105	35	65	5	42
ASE_00428	RNaseP_bact_a links to Rfam database...	0.24	0.26	0.22	33	76483	121	13	107	1	92
ASE_00430	RNaseP_bact_a links to Rfam database...	0.16	0.18	0.14	17	46852	102	10	92	0	80
ASE_00437	RNaseP_bact_a links to Rfam database...	0.00	0.00	0.00	0	79238	164	12	151	1	135
ASE_00451	RNaseP_bact_a links to Rfam database...	0.20	0.22	0.19	27	70731	118	8	110	0	98
SRP_00103	Metazoa_SRP links to Rfam database...	0.00	0.00	0.00	0	45319	132	14	118	0	102
SRP_00173	Bacteria_large_SRP links to Rfam database...	0.00	0.00	0.00	0	38104	124	13	109	2	90
SRP_00234	Bacteria_large_SRP links to Rfam database...	0.21	0.24	0.18	21	36200	97	19	75	3	65
SRP_00308	Bacteria_large_SRP links to Rfam database...	0.14	0.17	0.12	15	36189	112	18	93	1	73
SRP_00317	Metazoa_SRP links to Rfam database...	0.14	0.16	0.12	16	45018	116	16	100	0	82
SRP_00337	Bacteria_large_SRP links to Rfam database...	0.42	0.46	0.38	42	35400	70	15	54	1	49
TMR_00123	tmRNA links to Rfam database...	0.19	0.23	0.16	23	66283	126	20	104	2	78
TMR_00399	tmRNA links to Rfam database...	0.20	0.26	0.16	24	64833	130	38	85	7	70
TMR_00443	tmRNA links to Rfam database...	0.17	0.20	0.15	21	67018	126	24	98	4	83
TMR_00469	tmRNA links to Rfam database...	0.10	0.12	0.08	12	64469	145	27	112	6	88
TMR_00519	tmRNA links to Rfam database...	0.04	0.05	0.03	5	63046	141	33	106	2	90
TMR_00528	tmRNA links to Rfam database...	0.13	0.15	0.11	15	63051	131	20	104	7	82
TMR_00571	tmRNA links to Rfam database...	0.05	0.06	0.04	6	60577	149	19	124	6	93
TMR_00584	tmRNA links to Rfam database...	0.01	0.01	0.01	1	60922	159	33	119	7	96
TMR_00703	tmRNA links to Rfam database...	0.10	0.12	0.08	12	67376	140	26	114	0	87

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.

Table of contents:

Overview

Performance plots

Performance of RNAalifold(20) - scored higher in this pairwise comparison

1. Total counts & total scores for RNAalifold(20)

2. Individual counts for RNAalifold(20) [ download as .csv ]

Performance of NanoFolder - scored lower in this pairwise comparison

1. Total counts & total scores for NanoFolder

2. Individual counts for NanoFolder [ download as .csv ]