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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of RNASampler(20) - scored higher in this pairwise comparison

  4. Performance of MXScarna(20) - scored lower in this pairwise comparison

  5. Compile and download dataset for RNASampler(20) & MXScarna(20) [.zip] - may take several seconds...


Overview

Metric RNASampler(20) MXScarna(20)
MCC 0.840 > 0.837
Average MCC ± 95% Confidence Intervals 0.844 ± 0.055 > 0.841 ± 0.068
Sensitivity 0.714 < 0.752
Positive Predictive Value 0.990 > 0.935
Total TP 95 < 100
Total TN 14637 > 14626
Total FP 3 < 9
Total FP CONTRA 1 < 2
Total FP INCONS 0 < 5
Total FP COMP 2 = 2
Total FN 38 > 33
P-value 0.0

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Performance plots


  1. Comparison of performance of RNASampler(20) and MXScarna(20). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for RNASampler(20) and MXScarna(20)).

  2. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for RNASampler(20) and MXScarna(20)).

  3. Comparison of average Matthews Correlation Coefficients (MCCs) for RNASampler(20) and MXScarna(20). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for RNASampler(20) and MXScarna(20)).

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Performance of RNASampler(20) - scored higher in this pairwise comparison

1. Total counts & total scores for RNASampler(20)

Total Base Pair Counts
Total TP 95
Total TN 14637
Total FP 3
Total FP CONTRA 1
Total FP INCONS 0
Total FP COMP 2
Total FN 38
Total Scores
MCC 0.840
Average MCC ± 95% Confidence Intervals 0.844 ± 0.055
Sensitivity 0.714
Positive Predictive Value 0.990
Nr of predictions 5

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2. Individual counts for RNASampler(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
PDB_00571 0.87 0.80 0.95 20 3300 1 1 0 0 5
PDB_00828 0.86 0.74 1.00 20 2465 0 0 0 0 7
PDB_00829 0.86 0.75 1.00 18 2260 0 0 0 0 6
PDB_01020 0.86 0.74 1.00 17 2261 1 0 0 1 6
PDB_01073 0.77 0.59 1.00 20 4351 1 0 0 1 14

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Performance of MXScarna(20) - scored lower in this pairwise comparison

1. Total counts & total scores for MXScarna(20)

Total Base Pair Counts
Total TP 100
Total TN 14626
Total FP 9
Total FP CONTRA 2
Total FP INCONS 5
Total FP COMP 2
Total FN 33
Total Scores
MCC 0.837
Average MCC ± 95% Confidence Intervals 0.841 ± 0.068
Sensitivity 0.752
Positive Predictive Value 0.935
Nr of predictions 5

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2. Individual counts for MXScarna(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
PDB_00571 0.76 0.68 0.85 17 3301 3 1 2 0 8
PDB_00828 0.86 0.74 1.00 20 2465 0 0 0 0 7
PDB_00829 0.89 0.79 1.00 19 2259 0 0 0 0 5
PDB_01020 0.88 0.78 1.00 18 2260 0 0 0 0 5
PDB_01073 0.81 0.76 0.87 26 4341 6 1 3 2 8

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.