CompaRNA - on-line benchmarks of RNA structure prediction methods

Laboratory of Structural Bioinformatics @ Adam Mickiewicz University in Poznan

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Overview

Metric	MXScarna(20)		CRWrnafold
MCC	0.690	>	0.537
Average MCC ± 95% Confidence Intervals	0.690 ± 0.019	>	0.534 ± 0.052
Sensitivity	0.628	>	0.529
Positive Predictive Value	0.759	>	0.545
Total TP	7161	>	6032
Total TN	27683844	>	27682205
Total FP	3192	<	5577
Total FP CONTRA	318	<	666
Total FP INCONS	1954	<	4374
Total FP COMP	920	>	537
Total FN	4239	<	5368
P-value	5.02343278931e-08

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Performance plots

Comparison of performance of MXScarna(20) and CRWrnafold. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for MXScarna(20) and CRWrnafold).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for MXScarna(20) and CRWrnafold).
Comparison of average Matthews Correlation Coefficients (MCCs) for MXScarna(20) and CRWrnafold. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for MXScarna(20) and CRWrnafold).

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Performance of MXScarna(20) - scored higher in this pairwise comparison

1. Total counts & total scores for MXScarna(20)

Total Base Pair Counts
Total TP	7161
Total TN	27683844
Total FP	3192
Total FP CONTRA	318
Total FP INCONS	1954
Total FP COMP	920
Total FN	4239

Total Scores
MCC	0.690
Average MCC ± 95% Confidence Intervals	0.690 ± 0.019
Sensitivity	0.628
Positive Predictive Value	0.759
Nr of predictions	25

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2. Individual counts for MXScarna(20) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_00054	SSU_rRNA_bacteria links to Rfam database...	0.68	0.63	0.74	288	1107425	137	16	87	34	168
CRW_00068	SSU_rRNA_bacteria links to Rfam database...	0.69	0.64	0.74	293	1108909	137	18	85	34	164
CRW_00140	SSU_rRNA_bacteria links to Rfam database...	0.76	0.71	0.81	328	1135874	114	12	64	38	135
CRW_00173	SSU_rRNA_bacteria links to Rfam database...	0.57	0.52	0.63	232	1082285	168	19	120	29	213
CRW_00245	SSU_rRNA_bacteria links to Rfam database...	0.73	0.67	0.81	302	1105955	106	13	58	35	151
CRW_00270	SSU_rRNA_bacteria links to Rfam database...	0.72	0.67	0.77	306	1111891	121	14	75	32	149
CRW_00271	SSU_rRNA_bacteria links to Rfam database...	0.70	0.65	0.77	298	1122364	122	17	72	33	164
CRW_00273	SSU_rRNA_bacteria links to Rfam database...	0.68	0.62	0.74	277	1085225	135	13	86	36	169
CRW_00275	SSU_rRNA_bacteria links to Rfam database...	0.71	0.63	0.80	289	1114908	114	13	61	40	168
CRW_00277	SSU_rRNA_bacteria links to Rfam database...	0.68	0.63	0.73	286	1110405	132	17	87	28	167
CRW_00278	SSU_rRNA_bacteria links to Rfam database...	0.71	0.62	0.80	280	1129906	107	12	58	37	170
CRW_00280	SSU_rRNA_bacteria links to Rfam database...	0.72	0.66	0.78	301	1117875	125	10	74	41	152
CRW_00281	SSU_rRNA_bacteria links to Rfam database...	0.71	0.65	0.78	303	1144954	117	13	71	33	161
CRW_00284	SSU_rRNA_bacteria links to Rfam database...	0.69	0.62	0.77	281	1131397	117	9	73	35	175
CRW_00285	SSU_rRNA_bacteria links to Rfam database...	0.70	0.64	0.77	292	1117883	123	15	70	38	166
CRW_00466	SSU_rRNA_bacteria links to Rfam database...	0.63	0.58	0.69	266	1116382	147	16	101	30	192
CRW_00589	SSU_rRNA_bacteria links to Rfam database...	0.69	0.62	0.76	277	1094097	130	6	80	44	168
CRW_00590	SSU_rRNA_bacteria links to Rfam database...	0.72	0.67	0.78	303	1119366	134	11	76	47	149
CRW_00591	SSU_rRNA_bacteria links to Rfam database...	0.74	0.68	0.81	303	1098531	115	7	62	46	143
CRW_00772	SSU_rRNA_bacteria links to Rfam database...	0.60	0.54	0.67	217	945677	148	10	96	42	187
CRW_00789	SSU_rRNA_bacteria links to Rfam database...	0.67	0.60	0.75	268	1137427	134	8	83	43	179
CRW_00849	SSU_rRNA_bacteria links to Rfam database...	0.61	0.55	0.68	260	1117878	154	17	105	32	210
CRW_00997	SSU_rRNA_bacteria links to Rfam database...	0.74	0.69	0.79	322	1135872	121	12	72	37	142
PDB_00703	SSU_rRNA_bacteria links to Rfam database...	0.69	0.60	0.79	295	1073472	114	10	68	36	200
PDB_01273	SSU_rRNA_bacteria links to Rfam database...	0.69	0.60	0.79	294	1117886	120	10	70	40	197

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Performance of CRWrnafold - scored lower in this pairwise comparison

1. Total counts & total scores for CRWrnafold

Total Base Pair Counts
Total TP	6032
Total TN	27682205
Total FP	5577
Total FP CONTRA	666
Total FP INCONS	4374
Total FP COMP	537
Total FN	5368

Total Scores
MCC	0.537
Average MCC ± 95% Confidence Intervals	0.534 ± 0.052
Sensitivity	0.529
Positive Predictive Value	0.545
Nr of predictions	25

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2. Individual counts for CRWrnafold [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_00054	SSU_rRNA_bacteria links to Rfam database...	0.57	0.56	0.57	257	1107367	210	22	170	18	199
CRW_00068	SSU_rRNA_bacteria links to Rfam database...	0.57	0.57	0.58	259	1108856	209	20	170	19	198
CRW_00140	SSU_rRNA_bacteria links to Rfam database...	0.49	0.49	0.48	226	1135811	256	30	211	15	237
CRW_00173	SSU_rRNA_bacteria links to Rfam database...	0.38	0.38	0.39	168	1082220	282	31	237	14	277
CRW_00245	SSU_rRNA_bacteria links to Rfam database...	0.53	0.53	0.54	240	1105883	225	26	179	20	213
CRW_00270	SSU_rRNA_bacteria links to Rfam database...	0.49	0.49	0.50	225	1111832	246	27	202	17	230
CRW_00271	SSU_rRNA_bacteria links to Rfam database...	0.69	0.67	0.71	311	1122312	152	21	107	24	151
CRW_00273	SSU_rRNA_bacteria links to Rfam database...	0.41	0.41	0.41	181	1085155	279	39	226	14	265
CRW_00275	SSU_rRNA_bacteria links to Rfam database...	0.65	0.65	0.66	296	1114820	177	28	127	22	161
CRW_00277	SSU_rRNA_bacteria links to Rfam database...	0.44	0.43	0.44	196	1110351	263	35	213	15	257
CRW_00278	SSU_rRNA_bacteria links to Rfam database...	0.41	0.40	0.42	182	1129824	270	20	230	20	268
CRW_00280	SSU_rRNA_bacteria links to Rfam database...	0.67	0.66	0.68	299	1117818	160	18	125	17	154
CRW_00281	SSU_rRNA_bacteria links to Rfam database...	0.60	0.59	0.61	274	1144893	197	27	147	23	190
CRW_00284	SSU_rRNA_bacteria links to Rfam database...	0.51	0.50	0.51	228	1131314	245	27	191	27	228
CRW_00285	SSU_rRNA_bacteria links to Rfam database...	0.68	0.67	0.69	305	1117819	160	25	111	24	153
CRW_00466	SSU_rRNA_bacteria links to Rfam database...	0.71	0.70	0.71	320	1116316	158	22	107	29	138
CRW_00589	SSU_rRNA_bacteria links to Rfam database...	0.35	0.34	0.36	153	1094035	290	40	232	18	292
CRW_00590	SSU_rRNA_bacteria links to Rfam database...	0.61	0.59	0.64	268	1119334	184	21	133	30	184
CRW_00591	SSU_rRNA_bacteria links to Rfam database...	0.56	0.56	0.56	249	1098461	218	30	163	25	197
CRW_00772	SSU_rRNA_bacteria links to Rfam database...	0.19	0.18	0.19	74	945610	325	42	274	9	330
CRW_00789	SSU_rRNA_bacteria links to Rfam database...	0.51	0.50	0.52	224	1137356	236	32	174	30	223
CRW_00849	SSU_rRNA_bacteria links to Rfam database...	0.47	0.47	0.47	222	1117790	269	18	230	21	248
CRW_00997	SSU_rRNA_bacteria links to Rfam database...	0.69	0.69	0.69	318	1135820	167	27	113	27	146
PDB_00703	SSU_rRNA_bacteria links to Rfam database...	0.65	0.61	0.69	304	1073402	166	18	121	27	191
PDB_01273	SSU_rRNA_bacteria links to Rfam database...	0.54	0.52	0.56	253	1117806	233	20	181	32	238

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.

Table of contents:

Overview

Performance plots

Performance of MXScarna(20) - scored higher in this pairwise comparison

1. Total counts & total scores for MXScarna(20)

2. Individual counts for MXScarna(20) [ download as .csv ]

Performance of CRWrnafold - scored lower in this pairwise comparison

1. Total counts & total scores for CRWrnafold

2. Individual counts for CRWrnafold [ download as .csv ]