Genesilico metadisorder service

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Results for job: SUN1

All residues whose disorder probability is over 0.5 are considered as disordered.
For visibility only 4 plots corresponding to predictions from final metapredictions had been shown. To see results from primary methods click on the shadowed name of method in legend (the left side of plot).

Alternatively you can see results in simple text format here

Short description of meta methods:

MetaDisorderMD2 -CASP9 winning method (group number 147) - a method based on 13 disorder predictors and gaps in alignment produced by 8 fold recognition methods, optimized by Sww score (see Help page for details) using genetic algorithm. If you are looking for the most accurate disorder predictor, you should use this one, according CASP9 its AUC is 0.839; MetaDisorderMD2 result file
MetaDisorderMD - (group 374, fourth place in CASP9), AUC 0.816, similar to MetaDisorderMD2, but during optimization via AUC is 0.839; MetaDisorderMD result file
MetaDisorder - CASP8 winning method (group 153 in casp8, and group 010 in casp9) - metaprediction based on 13 disorder predictors AUC is 0.839; MetaDisorder3D result file
MetaDisorder3D - (group 421), counts gaps as disorder in top ten alignments produced by 8 different fold recognition methods, method and alignment efficiency to detect disorder was optimized by GA, tested during CASP9 as a reference to other meta methods, results are far AUC is 0.839; MetaDisorder result file

Primary predictors used by meta methods:
a) fold recognition methods:

^{HHsearch run over pdb70 database}

1........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910....

pdbid score model MDFSRLHMYSPPQCVPENTGYTYALSSSYSSDALDFETEHKLDPVFDSPRMSRRSLRLATTACTLGDGEAVGADSGTSSAVSLKNRAARTTKQRRSTNKSAFSINHVSRQVTSSGVSHGGTVSLQDAVTRRPPVLDESWIREQTTVDHFWGLDDDGDLKGGNKAAIQGNGDVGAAAATAHNGFSCSNCSMLSERKDVLTAHPAAPGPVSRVYSRDRNQKCGASFYVNRILWLARYTASSFSSFLVQLFQVVLMKLSYESENYKLKTHESKDCESESYKSKSHESKAHASYYGRMNVREVLREDGHLSVNGEALCDDCKGKRHLDAHTAAHSQSPRLPGRAGTLWHIWACAGYFLLQILRRIGAVGQAVSRTAWSALWLAVVAPGKAASGVFWWLGIGWYQFVTLISWLNVFLLTRCLRNICKFLVLLIPLFLLLAGLSLRGQGNFFSFLPVLNWASMHRTQRVDDPQDVFKPTTSRLKQPLQGDSEAFPWHWMSGVEQQVASLSGQCHHHGENLRELTTLLQKLQARVDQMEGGAAGPSASVRDAVGQPPRETDFMAFHQEHEVRMSHLEDILGKLREKSEAIQKELEQTKQKTISAVGEQLLPTVEHLQLELDQLKSELSSWRHVKTGCETVDAVQERVDVQVREMVKLLFSEDQQGGSLEQLLQRFSSQFVSKGDLQTMLRDLQLQILRNVTHHVSVTKQLPTSEAVVSAVSEAGASGITEAQARAIVNSALKLYSQDKTGMVDFALESGGGSILSTRCSETYETKTALMSLFGIPLWYFSQSPRVVIQPDIYPGNCWAFKGSQGYLVVRLSMMIHPAAFTLEHIPKTLSPTGNISSAPKDFAVYGLENEYQEEGQLLGQFTYDQDGESLQMFQALKRPDDTAFQIVELRIFSNWGHPEYTCLYRFRVHGEPVK

4dxt A 100.00 ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GPGVTEEQVHHIVKQALQRYSEDRIGLADYALESGGASVISTRCSETYETKTALLSLFGIPLWYHSQSPRVILQPDVHPG-----------------------------------------------------------------------------------------------------------------------

2yc2 A 99.26 -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GAASMKDYAREENGGLVVMASCSDE------------------RFPPENMLDGK--DNTFWVTTGMFQEFVLRLESCIR--------------------------------------------------------------------------------------------------

1tvg A 97.97 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MGHH-----------------------HHHHSHMRKIDLCLSSEGSEVILATSSD---EK---------------HPPEN--------------------------------------------------------------------------------------------------------------------------------

2efr A 85.15 -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RMKQLEDKVEELLSK---NYHLENEVAR----LKKLLERAEERAELSEGKSAETVTN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

2yfu A 77.43 -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MASYP--KLTGTVIGTQGSWNNI---------G-------NTIHKAF--DGDLNTFFDGPTNGCWLGLDFGEGVVIT------------------------------------------------------------------------------------------------

2v72 A 76.37 ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GMASAIIETSEMTASA--TSE-EG----------------QDPASSAI--DGNINTMWHTKALPQSLSVNL-------------------------------------------------------------------------------------------------------

2zdi C 74.40 ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MIRMAQNNKELEKLAYEYQVLQAQAQILAQNLELLNLAKAEVQTVRETLENLKKIK-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

3c9i A 71.00 ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GALVPRDPSLNNPVVIQATRLDAPRNVFSKSYLAIAGKAEAGQGAQDV-EL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

2jee A 63.47 ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MTMS---LEVFEKLEAKVQQAIDTITLLQMEIEELKEKNNSLSQENAQHQREELERENNHLKEQQNGWQ------ERL-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

1fxk A 62.05 -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QNVQHQLAQFQQLQQQAQAISVQKQTVEMQINETQKALEELSRAVYKSSGNILIRVAKDELTEELQEKLETLQLR--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

^{HHsearch run over CDD database}

1........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910....

pdbid score model MDFSRLHMYSPPQCVPENTGYTYALSSSYSSDALDFETEHKLDPVFDSPRMSRRSLRLATTACTLGDGEAVGADSGTSSAVSLKNRAARTTKQRRSTNKSAFSINHVSRQVTSSGVSHGGTVSLQDAVTRRPPVLDESWIREQTTVDHFWGLDDDGDLKGGNKAAIQGNGDVGAAAATAHNGFSCSNCSMLSERKDVLTAHPAAPGPVSRVYSRDRNQKCGASFYVNRILWLARYTASSFSSFLVQLFQVVLMKLSYESENYKLKTHESKDCESESYKSKSHESKAHASYYGRMNVREVLREDGHLSVNGEALCDDCKGKRHLDAHTAAHSQSPRLPGRAGTLWHIWACAGYFLLQILRRIGAVGQAVSRTAWSALWLAVVAPGKAASGVFWWLGIGWYQFVTLISWLNVFLLTRCLRNICKFLVLLIPLFLLLAGLSLRGQGNFFSFLPVLNWASMHRTQRVDDPQDVFKPTTSRLKQPLQGDSEAFPWHWMSGVEQQVASLSGQCHHHGENLRELTTLLQKLQARVDQMEGGAAGPSASVRDAVGQPPRETDFMAFHQEHEVRMSHLEDILGKLREKSEAIQKELEQTKQKTISAVGEQLLPTVEHLQLELDQLKSELSSWRHVKTGCETVDAVQERVDVQVREMVKLLFSEDQQGGSLEQLLQRFSSQFVSKGDLQTMLRDLQLQILRNVTHHVSVTKQLPTSEAVVSAVSEAGASGITEAQARAIVNSALKLYSQDKTGMVDFALESGGGSILSTRCSETYETKTALMSLFGIPLWYFSQSPRVVIQPDIYPGNCWAFKGSQGYLVVRLSMMIHPAAFTLEHIPKTLSPTGNISSAPKDFAVYGLENEYQEEGQLLGQFTYDQDGESLQMFQALKRPDDTAFQIVELRIFSNWGHPEYTCLYRFRVHGEPVK

PF09387 100.00 ------------------------------------------------------------TAYASGDGQAAHSHSSTSNATSLRDRSSRTQKQRRSASKPAFSINHWSRKDTSSGSSHLSSVSHRDALISRSPVLDES----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

PF07738 100.00 ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HNPEAKPPSNILSPDYMPGPCWAFEGSKGWLTIELSEPIYVTSVTIEHVEKSIAP---FSSAPKDFEVWGSVDYPDE-------------------------------------------------------------

d1tvga 96.33 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IDLCLSSEGSEVILA--TSSDEKH----------------PPENII--DGNPETFWTTTGMFPEFIICFHKH-----VR---------------------------------------------------------------------------------------------

cd00057 62.30 -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EPLGMESGL---ADDQI--T-ASSSYSS---------------GWEASRA---RLNSDNAWTPAVPPQWLQVDLGKTR---------------------------------------------------------------------------------------------------

d1x5fa1 61.83 --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EHAPAT---TGPLPSAPRDVVASLVSTRSDPHGDNLTYSVFYKEGIARERVENTSHPGEMQVTIQNLMP-----------------------

PF04156 57.98 -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SKKQ-RIISIILIILGILLIASGIAASGLGALISFILGIALLALGVVLLSLGLLCLLSKRPVQSVRPQQIEE-PR--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

PF07445 54.66 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LQQLEQQLQQLAQQAAQLDRQR------GEQHQARFDRQ--LFSCRSQRLSDYLQEI--EQTLAQLQQQVENRLQQVAF---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

PF04880 51.14 ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SLEDFESKLNQAIERLESEL---------DEKENLREEVQRLKDELRDLKQEL-IVQEKLRKANRKSRPSSSASLS---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

TIGR0210 50.81 -AFDDKFYYDELGAVYTPEKTVFRVWAPTATELLLYKSGEDGEPYK-VVKMKRGE-----NGVWSAVLEGDLHGYFYT----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

^{PSI-BLAST run over PDB70 database (4 iterations)}

1........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910....

pdbid score model MDFSRLHMYSPPQCVPENTGYTYALSSSYSSDALDFETEHKLDPVFDSPRMSRRSLRLATTACTLGDGEAVGADSGTSSAVSLKNRAARTTKQRRSTNKSAFSINHVSRQVTSSGVSHGGTVSLQDAVTRRPPVLDESWIREQTTVDHFWGLDDDGDLKGGNKAAIQGNGDVGAAAATAHNGFSCSNCSMLSERKDVLTAHPAAPGPVSRVYSRDRNQKCGASFYVNRILWLARYTASSFSSFLVQLFQVVLMKLSYESENYKLKTHESKDCESESYKSKSHESKAHASYYGRMNVREVLREDGHLSVNGEALCDDCKGKRHLDAHTAAHSQSPRLPGRAGTLWHIWACAGYFLLQILRRIGAVGQAVSRTAWSALWLAVVAPGKAASGVFWWLGIGWYQFVTLISWLNVFLLTRCLRNICKFLVLLIPLFLLLAGLSLRGQGNFFSFLPVLNWASMHRTQRVDDPQDVFKPTTSRLKQPLQGDSEAFPWHWMSGVEQQVASLSGQCHHHGENLRELTTLLQKLQARVDQMEGGAAGPSASVRDAVGQPPRETDFMAFHQEHEVRMSHLEDILGKLREKSEAIQKELEQTKQKTISAVGEQLLPTVEHLQLELDQLKSELSSWRHVKTGCETVDAVQERVDVQVREMVKLLFSEDQQGGSLEQLLQRFSSQFVSKGDLQTMLRDLQLQILRNVTHHVSVTKQLPTSEAVVSAVSEAGASGITEAQARAIVNSALKLYSQDKTGMVDFALESGGGSILSTRCSETYETKTALMSLFGIPLWYFSQSPRVVIQPDIYPGNCWAFKGSQGYLVVRLSMMIHPAAFTLEHIPKTLSPTGNISSAPKDFAVYGLENEYQEEGQLLGQFTYDQDGESLQMFQALKRPDDTAFQIVELRIFSNWGHPEYTCLYRFRVHGEPVK

4dxt A 4.94086e-109 -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GVTEEQVHHIVKQALQRYSEDRIGLADYALESGGASVISTRCSETYETKTALLSLFGIPLWYHSQSPRVILQPDVHPGNCWAFQGPQGFAVVRLSARIRPTAVTLEHVPKALSPNSTISSAPKDFAIFGFDEDLQQEGTLLGKFTYDQDGEPIQTFH-FQAPTMATYQVVELRILTNWGHPEYTCIYRFRVHGEP--

2fxo A 0.0577602 --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EREKEMASMKEEFTRLKEKSEARRKELE---EKMVSLLQEK-----NDLQL---QVQAEQDNLADAEERCDQLIKNKIQLEAKVKEMNKRLEDEEEMNAELTAKKRKLEDEC---SELKRDIDDLELTLAK---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

4nqj A 2.15919 ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MEFLKLHQFLHSKEKDILTELREEGKALNEEMEL----NLSQLQEQCLLAKDML-VSIQAKTEQQNSFDFLKDITTLLHSLEQGMKVATRELISRKLNLGQYKGPIQYMVWR---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

4k2p A 2.75028 ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NWITAIHSACATAVARHHHKEDTLRLLKSEIKKLEQKIDMDE------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

3nmd A 2.86744 ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GSLRDLQYALQEKIEELRQRD---------ALIDELELELDQLQNELDKYRSV--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

3wqt A 3.62207 -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ESNEIDFYEDTEINGSHIEKVLEGIREKNDVQETEV-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

2wq7 A 7.06071 -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DRMLGNVYCMQIPWQEHPDHLEAWTHGRTGYPFIDAIMRQL---------------RQEGWIHHLARHAVACFLTRGDL----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

^{PSI-BLAST run over CullPDB database (4 iterations)}

^{PHYRE - remote method}

1........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910....

pdbid score model MDFSRLHMYSPPQCVPENTGYTYALSSSYSSDALDFETEHKLDPVFDSPRMSRRSLRLATTACTLGDGEAVGADSGTSSAVSLKNRAARTTKQRRSTNKSAFSINHVSRQVTSSGVSHGGTVSLQDAVTRRPPVLDESWIREQTTVDHFWGLDDDGDLKGGNKAAIQGNGDVGAAAATAHNGFSCSNCSMLSERKDVLTAHPAAPGPVSRVYSRDRNQKCGASFYVNRILWLARYTASSFSSFLVQLFQVVLMKLSYESENYKLKTHESKDCESESYKSKSHESKAHASYYGRMNVREVLREDGHLSVNGEALCDDCKGKRHLDAHTAAHSQSPRLPGRAGTLWHIWACAGYFLLQILRRIGAVGQAVSRTAWSALWLAVVAPGKAASGVFWWLGIGWYQFVTLISWLNVFLLTRCLRNICKFLVLLIPLFLLLAGLSLRGQGNFFSFLPVLNWASMHRTQRVDDPQDVFKPTTSRLKQPLQGDSEAFPWHWMSGVEQQVASLSGQCHHHGENLRELTTLLQKLQARVDQMEGGAAGPSASVRDAVGQPPRETDFMAFHQEHEVRMSHLEDILGKLREKSEAIQKELEQTKQKTISAVGEQLLPTVEHLQLELDQLKSELSSWRHVKTGCETVDAVQERVDVQVREMVKLLFSEDQQGGSLEQLLQRFSSQFVSKGDLQTMLRDLQLQILRNVTHHVSVTKQLPTSEAVVSAVSEAGASGITEAQARAIVNSALKLYSQDKTGMVDFALESGGGSILSTRCSETYETKTALMSLFGIPLWYFSQSPRVVIQPDIYPGNCWAFKGSQGYLVVRLSMMIHPAAFTLEHIPKTLSPTGNISSAPKDFAVYGLENEYQEEGQLLGQFTYDQDGESLQMFQALKRPDDTAFQIVELRIFSNWGHPEYTCLYRFRVHGEPVK

3unp A 0.0 -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GVTEEQVHHIVKQALQRYSEDRIGLADYALESGGASVISTRCSETYETKT----AFGIPLWYHSQSPRVILQPDVHPGNCWAFQGPQGFAVVRLSARIRPTAVTLEHVPKALSPNSTISSAPKDFAIFGFDEDLQQEGTLLGKFTYDQDGEPIQTFHF-QAPTMATYQVVELRILTNWGHPEYTCIYRFRVHGEPAH

1tvg A 9.6e-08 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IDLCLSSEGSEVI---------LATS---------SDEKHPPENIIDGN--PETFWTTTGMFPQFIICFHKHVRIERLVIQSYF------------VQTLKIEKSTSKEPVDFEQWIEKDLVHTEGQLQNEEIVAHGS---ATYLRFIIVSAFDH--FASVHSVSAEGTVV-

4cgk A 4.6e-05 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SNLTAQQQEAQKQVDQIQEQVSAIQAEQSNLQAENDRLQAESKKLEGEITELSKNIVSRNQSLEKQARSA---QTNGAVTSYINTIVNSKSITEAISRVAAMSEIVSANNKMLEQQKADKKAISEKQVANNDAINTVIANQQKLADDAQALTTKQAELKAAELSLAAEKATAEGKASLLEQKAAAEAEARAAAVAEAAYKEKRASQQQSVLASANTNLTAQVQAVSESAAAPVRAK-----------------VRPTYSTNASSYPIGECTWGVKTLAPWAGDYWGNGAQWATSAAAAGFRTGSTPQVGAIACWND-GGYGHVAVESTTRIQVNRTIGNHRGWFNP---TTTSEGFVTYIYA--------------------------------------------------------------------

2yc2 A 9e-06 -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MKDYAREENGGLVV---MASCSDE---------------RFPPENMLDGK--DNTFWVTTGMFPEFVLRLESCIRVSKITTLS------------LNVRKLAVEKCDQDKPDQFEKVFEVELANRRLQTEVHQVNIR-----AKYLKFILLQGHGE--FATVNRVSVVG----

1jhj A 0.0015 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DDNLETYWQSDGSQPLVNIQFRRKTTVKTLCI-YADYKSDESYT----PSKISVRVGNN--FHNLQEIRQLELVEPSGWIHVPLTDNHKKPTRTFMIQIAVLANHQNGRDTHMRQIKIYT----

2xqx B 0.0059 -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GGEGIEGXLNGTISLSDKWSSAQLSGSVDIRLTKPRTVVRWVXDHAGAGGESVNDGLXNTKDFDLYYKDA----DGEWKLAKEVRGNKAHVTDITLDKPIT---AQDWRLNVVSDNGTPWKIRIYNWKXYEK---

3oja B 0.033 -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YLDRLLQYIALTSVVEKVLEAEVNELRAEVQQLTNEQIQQEQLLQGLHAEIDTNLRRYRLKDGLARSSDNLNKVFTHLKERQAFKLRETQARRTEADQKETEDLEQENIALEKQLDNKRAKQAELRQETSLKRQKVKQLEA--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

1bf5 A 0.043 ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DKQKELDSKVRNVKDKVMCIEHEIKSLEDLQDEYDFKCKTLQNREHLLLKK--MYLMLDNKRKEVVHKIIELLNVTELTQNALINDELVEWKRRQQSACI-GGPPNACLDQLQNWFTIVAESLQQVRQQLKKLEELEQKYTYEHDPITKNKQVLWDRTFSLFQQ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

3hnm D 0.027 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DNNPGTQWLCRWDVKYFVFDXGKEYTLFRFGFANPVAPAAHVWA--GTSKAGYVEASID--NENWVKLKDWTSPKIGE-PNVNXDVPATQ---ARYIRFVITDTYPTYDRVSLGEVYAWG----

4pqq A 0.011 ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PENILVDKPNDQSSRWSSESNPQYLILKLERPAIVQNITFGKYEKTHV------CNLKKFKVFGGMN--EENMTELLSSGLKNDYN-KETFTLKHKIDEQMFPCIKIVPLLSWGPSFNFSIWYVELSG----

^{FFAS - remote method}

1........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910....

pdbid score model MDFSRLHMYSPPQCVPENTGYTYALSSSYSSDALDFETEHKLDPVFDSPRMSRRSLRLATTACTLGDGEAVGADSGTSSAVSLKNRAARTTKQRRSTNKSAFSINHVSRQVTSSGVSHGGTVSLQDAVTRRPPVLDESWIREQTTVDHFWGLDDDGDLKGGNKAAIQGNGDVGAAAATAHNGFSCSNCSMLSERKDVLTAHPAAPGPVSRVYSRDRNQKCGASFYVNRILWLARYTASSFSSFLVQLFQVVLMKLSYESENYKLKTHESKDCESESYKSKSHESKAHASYYGRMNVREVLREDGHLSVNGEALCDDCKGKRHLDAHTAAHSQSPRLPGRAGTLWHIWACAGYFLLQILRRIGAVGQAVSRTAWSALWLAVVAPGKAASGVFWWLGIGWYQFVTLISWLNVFLLTRCLRNICKFLVLLIPLFLLLAGLSLRGQGNFFSFLPVLNWASMHRTQRVDDPQDVFKPTTSRLKQPLQGDSEAFPWHWMSGVEQQVASLSGQCHHHGENLRELTTLLQKLQARVDQMEGGAAGPSASVRDAVGQPPRETDFMAFHQEHEVRMSHLEDILGKLREKSEAIQKELEQTKQKTISAVGEQLLPTVEHLQLELDQLKSELSSWRHVKTGCETVDAVQERVDVQVREMVKLLFSEDQQGGSLEQLLQRFSSQFVSKGDLQTMLRDLQLQILRNVTHHVSVTKQLPTSEAVVSAVSEAGASGITEAQARAIVNSALKLYSQDKTGMVDFALESGGGSILSTRCSETYETKTALMSLFGIPLWYFSQSPRVVIQPDIYPGNCWAFKGSQGYLVVRLSMMIHPAAFTLEHIPKTLSPTGNISSAPKDFAVYGLENEYQEEGQLLGQFTYDQDGESLQMFQALKRPDDTAFQIVELRIFSNWGHPEYTCLYRFRVHGEPVK

2tma A -17.1 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MDAIKKKMQMLKLDKENALDRAEQAEADKKAAEDRSKQLEDELVSLQKKLKEDELDKYSEALKDAQEKLELAEKKATDAEADVASLNRRIQLVEEELDRAQERLATALQKLEEAEK---AADESERGMKVIESRAQKDEEKMEIQEIQLKEAKHIAEDRKYEEVARKLVIIESDLERAEERAELSEKCAELEEEIKTVTNNLKSLEAQAEKYSQKEDKYEEEIKVLSDKLKEAETRAEFAERSVTKLEKSIDDLEDELYAQKLKYKAISEELDHALND--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

1c1g A -17 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MDAIKKKMQMLKLDKENALDRADEAEADKKAAEDRSKQLEDELVSLQKKLKEDELDKYSEALKDAQEKLELAEKKATDAEADVASLNRRIQLFEEELDRAQERLATALQKLEEAEK---AADESERGMKVIESRAQKDEEKMEIQEIQLKEAKHEDADRKYEEVARKLVIIESDLERAEERAELSEKCAELEEEIKTVTNNLKSLEAQAEKYSQKEDKYEEEIKVLSDKLKEAETRAEFAERSVTKLEKSIDDLEDELYAQKLKYKAISEELDHALND--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

2oev A -13.9 ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VNRSIAQMREATTLANGVLASLNLPAAIEDVSGDTVPQSILTKSRSVIEQGIQTVDQLIKELPELLQRNREILDESLRLLDEEEATDNDLRAKNELYKPLRAEGTNFRTVLDKAVQADGQVKECYQSHRDTIVLLCKPEPELNAAIPSANPAKTMQGSE-VVNVLKSLLSNLDEVKKEREGLNDLKSVNFDMTSKFLTALAQDGVINEEALSVTELDRVYGGLTTKVQESLKKQEGLLKNIQVSHQEFSKMKQSNNEANLREEVLKNLATAYDNFVELVANLKEGTKFYNELTEILVRFQNKCSDIVFA----------------------------------------------------------------------------------------------------------------------------------------------------------------------

1jch A -13.9 --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GGNTRDAVIRFPKDSGHNAVYVSVSDVLSPDQVKQRQDEENRRQQEWDATHPVEAAERNYERARAELNQANEDVARNQERQAKAVQVYNSRKSELDAANKTLADAIAEIKQFN------RFAHDPMAGGHRMWQMAGLKAQRAQTDVNNKQAAF-----DAAAKEKSDADAALSSAMESRKKKEKKRSAENNLNDEKNKPRKGFKDYGHDYHPAPKTENIKGLGDLKPGIPKTPKQNGGGKRKRWTGDKGRKIYEWDSQHGELEGYRASDGQHLGSFDPKTGNQLKGPDPKRNIKKY-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

3ibp A -13.8 -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SHMIASLSDSVSNAREERMALRQEQEQLQSRIQSLMQR--APVWLAAQNSLNQLSEQCGEEFTSSQDVTEYLQQLLEREREAIVERDEVGARKNAVDEEIE---RLSQPGGSEDQRLNALAERFGGVLLSEIYDDVSLEDAPYFSALYGPSRHAIVVPDLSQVTEHLEGLTDCPEDLYLIEGDPQSFDDSVFSVDELEKAVVVKIADRQWRYSRFPEVPLFGRAARESRIESLHAEREVLSERFATLSFDVQKTQRLHQAFSRFIGSHLAVAFESDPEAEIRQLNSRRVELERALSN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------

2v71 A -13.6 ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AMDFSSLKEETAYWKELSMKYKQSFQEARDELVEFQEGSRELEAELEA-------------QLVQAEQRNRDLQADNQRLKYEVEALKEKLEHQYAQS-YKQVSVLEDDLSQTRAIKEQLHKY---VRELEQANDDLERAKRATIMSLEDFEQRLNQAIERNAFLESELDEKESLLVSVQRLKDEARDLRQELAVRERQQEVTRK-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

1bg1 A -13.6 -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QANHPTAAVVTEKQQMLEQHLQDVRKRVQDLEQKMKVVENLQDDFDFNYKTLKSQGDMQDLNGNNQSVTRQKMQQLEQMLTALDQMRRSIVSELAGLLSAMEYVQKTLTDEELADWKRRQQIACIGGPPNICLDRLENWITSLAESQLQTRQQIKKLEELQQKVSYKGDPIVQHRPMLEERIVELFRNLMKSAFVVERQPCMPMHPDRPLVIKTGVQFTTKVRLLVKFPELNYQLKIKVCIDKDSGDVAALRGSRKFN---------------------------------------------------------------------------------------------------------------------------------------------------------------------

1yvl A -13.5 -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KQDWEHAANDVSFATIRFHDLLSQLDDQYSRFSLENNFLLQHNIRKSKRNLQDNFQEDPIQMSMIIYSCLKEERKILENAQRFNQAQSGNIQSTVMLDKQKELDSKVRNVKDKVMCIEHEIKSLEDLQDEYDFKCKTLQNREHETNKSDQKQEQLLLKKMYLMLDNKRKEVVHKIIELLNVTELTQNEWKRRQQSACIGGPPNACLDQLQNWFTIVAESLQQVRQQLKKLEELEQKYTYEHDPITKNKQVLWDRTFSLFQQLIQSSFVVERQPCMPTHPQRPLVLKTGVQFTVK---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

1y1u A -13.2 --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GVLVDAMSQKHLQINQRFEELRLITQDTENELKKLQQTQEYFIIQYQESLRIQAQFAQLGQLNPQERMSQQKQVSLETWLQREAQTLQQYRVELAEKHQKTLQLLRKQQTIILDDELIQWKRR-QQLAGNGGPPEGSLDVLQSWCEKLAEIIWQNRQQIRRAEHLCQQLPIPGPVEEMLAEVNATITDIISALVTSTFIIEKQPPQVLKTQTKFAATVRLLVGGKLNVHMNPPQVKATIISEQQAKSLLKNENTRNECSGEILN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------

2p01 A -13.1 -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GEKEARLIRNLNVILAKYGLDGKKDARQVTSNSLSGTQEDGLDDPRLEKLWHKAKTSGKFSGEELDKLWREFLHHKEKVHEYNVLLETLSRTEEIHENVISPSDLSDIKGSVLHSRHTELKEKLRSINQGLDRLRRQGYSTEAEFEEPRVIDLWDLAQSANLTDKELEAFREELKHFEAKIEKHNHYQKQLEIAHEKLRHAESVGDG---------ERVSRSREKHALLEGRTKELGYTVKKHLQDLSGRISRARHNE-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

^mGenThreader

1........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910....

pdbid score model MDFSRLHMYSPPQCVPENTGYTYALSSSYSSDALDFETEHKLDPVFDSPRMSRRSLRLATTACTLGDGEAVGADSGTSSAVSLKNRAARTTKQRRSTNKSAFSINHVSRQVTSSGVSHGGTVSLQDAVTRRPPVLDESWIREQTTVDHFWGLDDDGDLKGGNKAAIQGNGDVGAAAATAHNGFSCSNCSMLSERKDVLTAHPAAPGPVSRVYSRDRNQKCGASFYVNRILWLARYTASSFSSFLVQLFQVVLMKLSYESENYKLKTHESKDCESESYKSKSHESKAHASYYGRMNVREVLREDGHLSVNGEALCDDCKGKRHLDAHTAAHSQSPRLPGRAGTLWHIWACAGYFLLQILRRIGAVGQAVSRTAWSALWLAVVAPGKAASGVFWWLGIGWYQFVTLISWLNVFLLTRCLRNICKFLVLLIPLFLLLAGLSLRGQGNFFSFLPVLNWASMHRTQRVDDPQDVFKPTTSRLKQPLQGDSEAFPWHWMSGVEQQVASLSGQCHHHGENLRELTTLLQKLQARVDQMEGGAAGPSASVRDAVGQPPRETDFMAFHQEHEVRMSHLEDILGKLREKSEAIQKELEQTKQKTISAVGEQLLPTVEHLQLELDQLKSELSSWRHVKTGCETVDAVQERVDVQVREMVKLLFSEDQQGGSLEQLLQRFSSQFVSKGDLQTMLRDLQLQILRNVTHHVSVTKQLPTSEAVVSAVSEAGASGITEAQARAIVNSALKLYSQDKTGMVDFALESGGGSILSTRCSETYETKTALMSLFGIPLWYFSQSPRVVIQPDIYPGNCWAFKGSQGYLVVRLSMMIHPAAFTLEHIPKTLSPTGNISSAPKDFAVYGLENEYQEEGQLLGQFTYDQDGESLQMFQALKRPDDTAFQIVELRIFSNWGHPEYTCLYRFRVHGEPVK

3unp A 5e-13 ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IGVTEEQVHHIVKQALQRYSEDRIGLADYALESGGASVISTRCSETYETKTA----FGIPLWYHSQSPRVILQPDVHPGNCWAFQGPQGFAVVRLSARIRPTAVTLEHVPKALSPNSTISSAPKDFAIFGFDEDLQQEGTLLGKFTYDQDGEPIQTFH-FQAPTMATYQVVELRILTNWGHPEYTCIYRFRVHGEPAH

3o8y A 0.001 GDVERAKLARDDQIMEWNPGFPLSIDAKCHKDLPR-------DIQFDSEKGVDFVLNYSKAMENLFINRFMHMFQSSWNFVKISNTISERVMNHWQENPVLI------RRCTELPEKLPVTTEMVECSLERQLSLEQEVQQGNIFIVDFELLDGIDANKTDPCTLQFLAAPICLLYKN--------------LANKIAIQLNQIPGDENPIFLPSDA----------KYDWLLAKIWVRSSDFHVHQTITHLLRTHLVSEVFGIAMYRQLPAVHEQLICECGLFDKANATGGGGHVQMVQRAMKDLTYASLCFPEAIKARG-----MESKEDIPYYFYRDDGLL-VWEAIRTFTAEVVDIYYEGDQVVEEPELQDFVNDVYVYGMRGRKSSGFPKSV-----------------KSREQLSEYLTVVIFTASAQHAAVNFGQYDWASWIPNAPPTMRAPPPTAKGVVTQFQENELFL---GMYPEEHFIE-----------------KPVKEAMARFRKNLEAIVSVIAERNENLQLPSVAI--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

1y2m A 0.002 -----------------------------ASTNLAVAGSH-LPTTQAAPTDS--TLELDGYSLNLGDVVSAARKGRPKDSDEIRSKIDKSVEFLRTEDAISLQKALLEHQLCGVLPSSFDSFRLGRGL---ENSLPLEVVRGAMTIRVNSLTRGHSAVRHGITPIVPLRGTISASGDLSPLSYIAAAISGHPDSREAMALFNLEPVVL--------GPKVNGTAVSASMATLALHDAHMLSLLSQSLTAMTVEAM---------------VGHAGSFHPFLHD---------------VTRPHPTQIEVAGNIRKLLEGSRFAVHHEEEVDEGILRQDR-------------YPLRTSPQWLGPLVSDLIHAHAVLTIEAGQ----------------------STTDNPLIDVETMEKTRLGLAQIGKLNFTQLTEMLNAGMNR----------GLPSCLAAEDPSLSYHCPVTTHVQPAEMANQAVNSLALISARRTTESNDVLSLLLATHLYCVLQAIDLRAIEFEFKKQFGPAIVSLIDQHFGSAMSNLRDELVEKVNKTLAKRLEQTNSY------------------------DLVPRWHDAFSFAAGTVVEVLSSTSSLAAVNAWKVAAAESAISLTRQVRETFWSAASTSSPALSYLSPR-----------------TQILYAFVREDVFLGKQEVTIGSNVSKIYEAIKSG-------RINNVLLKML-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

1y2m A 0.002 LNAGMNRGL-PSCLAAEDPSL------SYH----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

3d3l A 0.002 ---------------------------------------------------------------------------WTLKAGALEMALKRVYTLLSSWNCLEGQKSALAEKVRQCWQDNGAN-----------PML----LRRSTSLPSRLVLPSGMELRAQLEKELQN-GSLFEADFILLDGIPAEKQYLAAEPNGIQIQPPNPSSPTPTLF----LPSDPPLAWLLAKSWVRNSDFQLHEIQVAEVIAVATMRCL----------------------PGLHFLIPHIRYGGHVQLLRRAAAQLT-------YCSLC-----PPDDLADRG-LLGLPGAAHDALRLWEIIARYVEGIVHLFYQRDDIVKGDELQAWCREITEVGLCQAQDRGFPVSF-----------------QSQSQLCHFLTMCVFTCTAQHAAINQGQLDWYAWVP-------------------NAPCTMRMPPPTTKEDVSLPDVRQACLQMAISWHLSSGPKPKAVLNQFRTDLEKLEKEITARNEQLDWPSVT---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

3d3l A 0.002 LDWP--YEYLKPSCIENSVT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

2iuj A 0.002 RKDPNSEKPGDFVYLPRDEAFGHLKSSDGNLLSLDFDNLSNITPIPIIKELFR------------TDGEQFLKYPPPKVM---------------QVDKSAWMTDEEFARETIAGLNPN----VIKIIEEFPLSSK---LDTQAYGDHTCIITKEPNLGGNKKLFILDHHDYLIPYLRKINANTTKTYATRTIKNDLSKPHPQGEEYGPEVYVPSSEGHWLNTHAVVEPFVIATNRHLSIYKLLFPHYRSLARKSLVNADGIIEKTF----------------------LWGRYSLEMSAVIYKDWVFTDQALPNDLVKRGVAVKDPSAPHGLIEDYPYASDGLEIWDAIKSWVEEYVSFYYKSDEELQKPELQAWWKELVEVGHGDLKDKPWWQKM-----------------QTREELVEASATLIWIASALHAAVNFGQYPYGGLIL-----NRPTISRRFMPEKGSPEYDALAKNPEKEFLKTITGKKETLIDLTIIEILSRHAGPLEAFKRFGKNLEEIEKKLIEKNNDETLRNRYGPAKMP-------------------------YTLLYPSSEEGLTFRGIPNSISI---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

2vn4 A 0.002 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SVDDFISTETPIALNNLLCNVGPDGCRAFGTSAGAVIASPSTIDPDYYTRDSALVFKNLIDRFTETYDAGLQRRIEQYITAQVTLQGLSNPSGSLADGELTLKPFTGNWGRPQR--------------DGPALRAIALIGYSKWLINNNYWPIVRNDLNYVAQYW------------------NQTGFDLWEANQHRALVEGATLAATLGQSG----SAYSSVAPQVLCFLQRFWVSSGGHTFDPNLGCDAGTFQPCSDKALSNLKVVVDSFRSIYGVNKGIPAGAAVAIGRYAEDVYYNGNPWYLATFAAAEQLYDAIYVWKKTGSITVTASSSSSTFTNIINAVSTYADGFLSEAAKYVPADGSLAE-----------------------------------QFDRNSGT--------PLSALHLTWSYASFLTATARRAGIVPPSWANSSASTIP----------STCSGASVVGSYSRPTATSFPPSQTPKGVPSGTPYTPLPCATPTVTFHELVSTQFGQTVKVAGNAAALLDAVNYADNHPLWIGTVNLEAGD------VVEYKYGQDGESDPTYTVPAVACVT-----QVVKEDTWQS-----------------

1rrh A 0.003 PDKGENH-ARPVLGGNDTFPYPRRGRTGRKPTRKDPNSESRSNDVFGHLKSSQNVLPLLQSAFDLNFTPREFDSGLYSGGIKLPTDIISKISIFRTDGEQAFPPPKVIQVSKSAWMTAGVNPNLIRCLKDFPPKLDSQVYG-----DHTSQITKEPNLEGLTDEAIQNKHDPIMPYLRRINAT---STKAYFLKNDLSLPHPQGDQSGAQVFLPADESHWLNTHAVVEPFIIATNRHLSIYKLLHPHYRLARLSL-----------------------VNDGGVIEQTFLWGRYSVEMSAVVYKDWVFTDQALPADLI-KRGMAIEDPSCPHGLVIEDYTVDGLEIWDAIKTWVHEYVFLYYKSDDTLREPELQACWKELVEVGHGDKKNEPWWPKMQT-----------------REELVEACAIIIWTASALHAAVNFGQYPYGGLILNRPT-----LSRRFMPEKGSAEYEELRKNPQKAYLKTITPKFQTLIDLSVIEILSRHTRALEAFKRFGNKLAQIENKLSERNND-------------------------EKLRNRCGPVQMPYTLLLPSSKEGLTFRGIPNSISI---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

1w27 A 0.003 ------------------------------EDPLYLDEVKKMVAEYRKP-----VVKLGGETLTISQVAAISARDGSGVTVELSKASSDWVMDSMNKGTDSYGVT--------TGFGATSHRRTKQGGNGSDNTLPHSATRAAMLVRINTLL--QGYLRGTITALLTGRPN---SKAVGPTGVILS-------PEEAFKLAGVEGGFF----------ELQPKFEANILAVLAEVMSAIFAEVMQQIEAAAIMEHILDGSAYVKAA--QKLHEMDPLQKPKQDRYALRTSSTKMIEREIN------SVNDNPLIDVSRN----KAIHGGNFQGTPIGVSMDNTRLAIAAIGKLMFAQFSELVFKGAEIAMASYCSELQFLANP------------VTNHVQSAEQHNQDVNSLSRKTSEAVEILKLMSTTFLVGLCQAIDLRHLEENLKSTVKNTVSSVAKRVLTMGVNGELHPSYIFAYIDDPCSATY-PLMQKLRQTLVEHALKNGDNERNEDELKALLPKESARAALESGNPAIPELGTEYLTGEKVTEKVFIAMSKGEDPLLECLESWNGAPLPIC------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

^PCONS5

1........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910....

pdbid score model MDFSRLHMYSPPQCVPENTGYTYALSSSYSSDALDFETEHKLDPVFDSPRMSRRSLRLATTACTLGDGEAVGADSGTSSAVSLKNRAARTTKQRRSTNKSAFSINHVSRQVTSSGVSHGGTVSLQDAVTRRPPVLDESWIREQTTVDHFWGLDDDGDLKGGNKAAIQGNGDVGAAAATAHNGFSCSNCSMLSERKDVLTAHPAAPGPVSRVYSRDRNQKCGASFYVNRILWLARYTASSFSSFLVQLFQVVLMKLSYESENYKLKTHESKDCESESYKSKSHESKAHASYYGRMNVREVLREDGHLSVNGEALCDDCKGKRHLDAHTAAHSQSPRLPGRAGTLWHIWACAGYFLLQILRRIGAVGQAVSRTAWSALWLAVVAPGKAASGVFWWLGIGWYQFVTLISWLNVFLLTRCLRNICKFLVLLIPLFLLLAGLSLRGQGNFFSFLPVLNWASMHRTQRVDDPQDVFKPTTSRLKQPLQGDSEAFPWHWMSGVEQQVASLSGQCHHHGENLRELTTLLQKLQARVDQMEGGAAGPSASVRDAVGQPPRETDFMAFHQEHEVRMSHLEDILGKLREKSEAIQKELEQTKQKTISAVGEQLLPTVEHLQLELDQLKSELSSWRHVKTGCETVDAVQERVDVQVREMVKLLFSEDQQGGSLEQLLQRFSSQFVSKGDLQTMLRDLQLQILRNVTHHVSVTKQLPTSEAVVSAVSEAGASGITEAQARAIVNSALKLYSQDKTGMVDFALESGGGSILSTRCSETYETKTALMSLFGIPLWYFSQSPRVVIQPDIYPGNCWAFKGSQGYLVVRLSMMIHPAAFTLEHIPKTLSPTGNISSAPKDFAVYGLENEYQEEGQLLGQFTYDQDGESLQMFQALKRPDDTAFQIVELRIFSNWGHPEYTCLYRFRVHGEPVK

2yc2 A 2.2746 -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GAASMKDYAREENGGLVVMASCSDE------------------RFPPENMLDGK--DNTFWVTTGMFQEFVLRLESCIR--------------------------------------------------------------------------------------------------

4dxt A 1.8277 ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GPGVTEEQVHHIVKQALQRYSEDRIGLADYALESGGASVISTRCSETYETKTALLSLFGIPLWYHSQSPRVILQPDVHPG-----------------------------------------------------------------------------------------------------------------------

1tvg A 1.5207 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MGHH-----------------------HHHHSHMRKIDLCLSSEGSEVILATSSD---EK---------------HPPEN--------------------------------------------------------------------------------------------------------------------------------

4k2p A 0.929 ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NWITAIHSACATAVARHHHKEDTLRLLKSEIKKLEQKIDMDE------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

4dxt A 0.8672 -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GVTEEQVHHIVKQALQRYSEDRIGLADYALESGGASVISTRCSETYETKTALLSLFGIPLWYHSQSPRVILQPDVHPGNCWAFQGPQGFAVVRLSARIRPTAVTLEHVPKALSPNSTISSAPKDFAIFGFDEDLQQEGTLLGKFTYDQDGEPIQTFH-FQAPTMATYQVVELRILTNWGHPEYTCIYRFRVHGEP--

4nqj A 0.7002 ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MEFLKLHQFLHSKEKDILTELREEGKALNEEMEL----NLSQLQEQCLLAKDML-VSIQAKTEQQNSFDFLKDITTLLHSLEQGMKVATRELISRKLNLGQYKGPIQYMVWR---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

2fxo A 0.6918 --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EREKEMASMKEEFTRLKEKSEARRKELE---EKMVSLLQEK-----NDLQL---QVQAEQDNLADAEERCDQLIKNKIQLEAKVKEMNKRLEDEEEMNAELTAKKRKLEDEC---SELKRDIDDLELTLAK---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

2jee A 0.5794 ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MTMS---LEVFEKLEAKVQQAIDTITLLQMEIEELKEKNNSLSQENAQHQREELERENNHLKEQQNGWQ------ERL-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

2zdi C 0.3889 ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MIRMAQNNKELEKLAYEYQVLQAQAQILAQNLELLNLAKAEVQTVRETLENLKKIK-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

1fxk A 0.3762 -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QNVQHQLAQFQQLQQQAQAISVQKQTVEMQINETQKALEELSRAVYKSSGNILIRVAKDELTEELQEKLETLQLR--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

b) disorder predictors:

DISOPRED2 result file

DISpro result file

DISPROT (VSL2) result file

GlobPlot result file

iPDA result file

IUPred long result file

IUPred short result file

Pdisorder result file

Poodle-l result file

Poodle-s result file

PrDOS result file

RONN result file

Spritz long result file

Spritz short result file

DisEMBL coils result file

DisEMBL hotloops result file

DisEMBL remark465 result file