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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of Murlet(20) - scored higher in this pairwise comparison

  4. Performance of NanoFolder - scored lower in this pairwise comparison

  5. Compile and download dataset for Murlet(20) & NanoFolder [.zip] - may take several seconds...


Overview

Metric Murlet(20) NanoFolder
MCC 0.591 > 0.197
Average MCC ± 95% Confidence Intervals 0.620 ± 0.046 > 0.272 ± 0.041
Sensitivity 0.450 > 0.227
Positive Predictive Value 0.778 > 0.174
Total TP 2816 > 1421
Total TN 2955931 > 2951363
Total FP 935 < 6934
Total FP CONTRA 92 < 1037
Total FP INCONS 711 < 5729
Total FP COMP 132 < 168
Total FN 3436 < 4831
P-value 3.56938820447e-08

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Performance plots


  1. Comparison of performance of Murlet(20) and NanoFolder. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Murlet(20) and NanoFolder).

  2. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for Murlet(20) and NanoFolder).

  3. Comparison of average Matthews Correlation Coefficients (MCCs) for Murlet(20) and NanoFolder. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Murlet(20) and NanoFolder).

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Performance of Murlet(20) - scored higher in this pairwise comparison

1. Total counts & total scores for Murlet(20)

Total Base Pair Counts
Total TP 2816
Total TN 2955931
Total FP 935
Total FP CONTRA 92
Total FP INCONS 711
Total FP COMP 132
Total FN 3436
Total Scores
MCC 0.591
Average MCC ± 95% Confidence Intervals 0.620 ± 0.046
Sensitivity 0.450
Positive Predictive Value 0.778
Nr of predictions 104

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2. Individual counts for Murlet(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
ASE_00083 0.54 0.39 0.75 43 62424 14 2 12 0 67
ASE_00185 0.28 0.16 0.48 21 73492 23 0 23 0 107
ASE_00190 0.38 0.22 0.67 20 45421 12 0 10 2 70
ASE_00221 0.58 0.44 0.78 51 64555 14 0 14 0 66
ASE_00228 0.53 0.44 0.63 38 46911 23 1 21 1 48
ASE_00229 0.61 0.48 0.76 42 42431 13 3 10 0 45
ASE_00238 0.45 0.30 0.68 34 64211 16 2 14 0 80
ASE_00248 0.76 0.63 0.91 72 62402 7 0 7 0 42
ASE_00255 0.53 0.39 0.72 51 74620 21 1 19 1 79
ASE_00257 0.55 0.43 0.69 42 50979 19 0 19 0 55
ASE_00267 0.76 0.61 0.95 54 45093 4 2 1 1 34
ASE_00270 0.21 0.14 0.32 18 72333 41 0 39 2 110
ASE_00279 0.63 0.48 0.84 48 53244 9 1 8 0 53
ASE_00285 0.45 0.33 0.62 40 68941 25 1 24 0 82
ASE_00294 0.55 0.37 0.83 63 114405 14 4 9 1 108
ASE_00298 0.22 0.15 0.32 17 67475 36 4 32 0 96
ASE_00318 0.66 0.49 0.89 58 80135 16 2 5 9 60
ASE_00321 0.66 0.52 0.84 46 54560 18 1 8 9 42
ASE_00335 0.60 0.48 0.76 56 75392 19 5 13 1 60
ASE_00340 0.45 0.34 0.60 29 46008 22 3 16 3 56
ASE_00367 0.71 0.57 0.89 49 43016 6 2 4 0 37
ASE_00372 0.40 0.31 0.53 31 51944 28 3 25 0 69
ASE_00376 0.57 0.40 0.82 42 56902 9 2 7 0 63
ASE_00386 0.54 0.36 0.80 35 50359 9 1 8 0 61
ASE_00393 0.55 0.41 0.73 38 47843 15 3 11 1 55
ASE_00412 0.51 0.32 0.79 34 58268 11 0 9 2 71
ASE_00416 0.45 0.33 0.62 42 77353 26 1 25 0 85
ASE_00422 0.50 0.35 0.70 33 46924 14 0 14 0 61
ASE_00427 0.42 0.43 0.41 20 40706 41 10 19 12 26
ASE_00428 0.47 0.34 0.67 42 76573 21 4 17 0 83
ASE_00430 0.50 0.37 0.68 36 46918 17 0 17 0 61
ASE_00437 0.42 0.32 0.56 43 79324 34 3 31 0 92
ASE_00451 0.56 0.41 0.76 51 70809 16 1 15 0 74
CRW_01535 0.75 0.57 1.00 21 7119 3 0 0 3 16
CRW_01539 0.90 0.86 0.94 32 7106 5 0 2 3 5
CRW_01563 0.87 0.81 0.94 30 6871 5 0 2 3 7
CRW_01583 0.87 0.81 0.94 30 7108 5 0 2 3 7
CRW_01590 0.72 0.57 0.91 21 7117 5 0 2 3 16
CRW_01593 0.87 0.81 0.94 30 7108 3 0 2 1 7
CRW_01595 0.89 0.84 0.94 31 8482 5 0 2 3 6
CRW_01603 0.85 0.73 1.00 27 7113 2 0 0 2 10
CRW_01617 0.84 0.76 0.93 28 7110 5 0 2 3 9
CRW_01625 0.67 0.59 0.76 22 7111 9 0 7 2 15
PDB_00070 0.76 0.71 0.81 17 2829 4 0 4 0 7
PDB_00571 0.59 0.52 0.68 13 3302 7 0 6 1 12
PDB_00828 0.84 0.70 1.00 19 2466 0 0 0 0 8
PDB_01236 0.71 0.52 0.97 28 11599 3 0 1 2 26
RFA_00416 0.97 0.93 1.00 14 1471 2 0 0 2 1
RFA_00434 0.97 0.93 1.00 14 1417 2 0 0 2 1
RFA_00436 0.97 0.93 1.00 14 1417 1 0 0 1 1
RFA_00442 0.97 0.93 1.00 14 1417 2 0 0 2 1
RFA_00664 0.00 0.00 0.00 0 990 0 0 0 0 14
RFA_00674 0.00 0.00 0.00 0 1128 0 0 0 0 14
RFA_00675 0.00 0.00 0.00 0 990 0 0 0 0 14
RFA_00677 0.00 0.00 0.00 0 990 0 0 0 0 14
RFA_00717 0.00 0.00 0.00 0 903 0 0 0 0 14
RFA_00730 0.75 0.75 0.75 9 891 4 0 3 1 3
RFA_00763 1.00 1.00 1.00 12 891 1 0 0 1 0
RFA_00765 0.75 0.75 0.75 9 891 4 0 3 1 3
SPR_00066 0.90 0.90 0.90 19 2829 2 0 2 0 2
SPR_00314 0.90 0.90 0.90 19 2905 2 0 2 0 2
SPR_00333 0.88 0.86 0.90 18 2755 2 0 2 0 3
SPR_00353 0.90 0.90 0.90 19 2829 2 0 2 0 2
SPR_00452 0.71 0.62 0.81 13 2834 3 0 3 0 8
SPR_00456 0.81 0.81 0.81 17 2829 4 0 4 0 4
SPR_00476 0.85 0.81 0.89 17 2756 2 0 2 0 4
SPR_00496 0.88 0.86 0.90 18 2755 2 0 2 0 3
SPR_00497 0.85 0.81 0.89 17 2756 2 0 2 0 4
SPR_00502 0.98 0.95 1.00 20 2906 0 0 0 0 1
SPR_00509 1.00 1.00 1.00 20 2906 0 0 0 0 0
SPR_00512 0.97 0.95 1.00 19 2907 0 0 0 0 1
SPR_00557 0.70 0.67 0.74 14 2831 5 0 5 0 7
SPR_00868 0.90 0.90 0.90 19 2905 2 0 2 0 2
SPR_00957 0.90 0.90 0.90 19 2982 2 0 2 0 2
SPR_01040 0.85 0.81 0.89 17 2756 2 0 2 0 4
SRP_00038 0.46 0.21 1.00 7 5043 0 0 0 0 26
SRP_00046 0.47 0.22 1.00 7 4746 0 0 0 0 25
SRP_00103 0.75 0.65 0.87 66 45375 12 1 9 2 36
SRP_00170 0.61 0.52 0.72 13 4077 6 2 3 1 12
SRP_00194 0.53 0.29 1.00 6 3234 0 0 0 0 15
SRP_00200 0.41 0.17 1.00 6 6897 0 0 0 0 30
SRP_00233 0.46 0.21 1.00 7 5144 0 0 0 0 26
SRP_00243 0.47 0.23 1.00 7 5144 0 0 0 0 24
SRP_00244 0.39 0.15 1.00 6 6897 1 0 0 1 33
SRP_00266 0.49 0.24 1.00 7 4649 0 0 0 0 22
SRP_00269 0.46 0.21 1.00 7 5043 0 0 0 0 26
SRP_00273 0.71 0.55 0.92 22 6762 2 1 1 0 18
SRP_00303 0.43 0.19 1.00 6 6664 1 0 0 1 26
SRP_00317 0.78 0.68 0.88 67 45074 14 0 9 5 31
SRP_00333 0.45 0.21 1.00 7 5144 0 0 0 0 27
SRP_00337 0.59 0.42 0.83 38 35465 9 0 8 1 53
SRP_00338 0.44 0.19 1.00 7 5453 0 0 0 0 29
SRP_00342 0.49 0.24 1.00 6 3999 0 0 0 0 19
SRP_00358 0.41 0.17 1.00 6 6322 0 0 0 0 29
SRP_00383 0.54 0.29 1.00 7 3233 0 0 0 0 17
TMR_00123 0.64 0.50 0.81 51 66367 17 3 9 5 50
TMR_00399 0.61 0.47 0.79 44 64924 18 2 10 6 50
TMR_00443 0.73 0.61 0.88 63 67089 13 0 9 4 41
TMR_00469 0.64 0.48 0.84 48 64563 10 3 6 1 52
TMR_00519 0.49 0.37 0.65 35 63136 23 2 17 4 60
TMR_00528 0.48 0.41 0.57 40 63120 36 7 23 6 57
TMR_00571 0.76 0.67 0.86 66 60649 15 2 9 4 33
TMR_00584 0.71 0.62 0.81 60 61001 17 4 10 3 37
TMR_00703 0.58 0.45 0.75 45 67468 19 3 12 4 54

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Performance of NanoFolder - scored lower in this pairwise comparison

1. Total counts & total scores for NanoFolder

Total Base Pair Counts
Total TP 1421
Total TN 2951363
Total FP 6934
Total FP CONTRA 1037
Total FP INCONS 5729
Total FP COMP 168
Total FN 4831
Total Scores
MCC 0.197
Average MCC ± 95% Confidence Intervals 0.272 ± 0.041
Sensitivity 0.227
Positive Predictive Value 0.174
Nr of predictions 104

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2. Individual counts for NanoFolder [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
ASE_00083 0.22 0.25 0.20 27 62347 108 12 95 1 83
ASE_00185 0.17 0.19 0.16 24 73382 134 14 116 4 104
ASE_00190 0.24 0.28 0.21 25 45334 93 14 78 1 65
ASE_00221 0.20 0.21 0.18 25 64484 112 10 101 1 92
ASE_00228 0.05 0.06 0.04 5 46858 109 17 91 1 81
ASE_00229 0.12 0.14 0.11 12 42380 97 12 82 3 75
ASE_00238 0.26 0.30 0.23 34 64111 119 18 98 3 80
ASE_00248 0.13 0.15 0.12 17 62340 124 9 115 0 97
ASE_00255 0.11 0.12 0.10 16 74530 146 16 129 1 114
ASE_00257 0.37 0.42 0.33 41 50917 85 15 67 3 56
ASE_00267 0.00 0.00 0.00 0 45036 115 9 105 1 88
ASE_00270 0.19 0.21 0.17 27 72232 132 14 117 1 101
ASE_00279 0.14 0.16 0.13 16 53177 109 16 92 1 85
ASE_00285 0.34 0.36 0.31 44 68866 98 14 82 2 78
ASE_00294 0.12 0.13 0.12 23 114287 172 11 160 1 148
ASE_00298 0.09 0.10 0.08 11 67389 129 8 120 1 102
ASE_00318 0.03 0.04 0.03 5 80039 156 21 135 0 113
ASE_00321 0.11 0.14 0.09 12 54484 122 22 97 3 76
ASE_00335 0.10 0.12 0.09 14 75304 151 22 126 3 102
ASE_00340 0.06 0.07 0.05 6 45943 110 13 94 3 79
ASE_00367 0.08 0.09 0.07 8 42960 110 10 93 7 78
ASE_00372 0.17 0.20 0.15 20 51871 113 19 93 1 80
ASE_00376 0.00 0.00 0.00 0 56822 136 9 122 5 105
ASE_00386 0.14 0.16 0.13 15 50284 106 9 95 2 81
ASE_00393 0.31 0.35 0.27 33 47773 90 18 71 1 60
ASE_00412 0.15 0.17 0.14 18 58183 111 14 96 1 87
ASE_00416 0.39 0.43 0.35 54 77267 103 18 82 3 73
ASE_00422 0.28 0.31 0.25 29 46856 87 9 77 1 65
ASE_00427 0.06 0.09 0.04 4 40651 105 35 65 5 42
ASE_00428 0.24 0.26 0.22 33 76483 121 13 107 1 92
ASE_00430 0.16 0.18 0.14 17 46852 102 10 92 0 80
ASE_00437 0.00 0.00 0.00 0 79238 164 12 151 1 135
ASE_00451 0.20 0.22 0.19 27 70731 118 8 110 0 98
CRW_01535 0.20 0.24 0.17 9 7088 43 7 36 0 28
CRW_01539 0.10 0.11 0.10 4 7099 40 1 36 3 33
CRW_01563 0.11 0.14 0.11 5 6856 43 5 37 1 32
CRW_01583 0.36 0.41 0.33 15 7095 31 8 22 1 22
CRW_01590 -0.01 0.00 0.00 0 7093 50 7 40 3 37
CRW_01593 0.32 0.38 0.29 14 7091 36 5 30 1 23
CRW_01595 -0.01 0.00 0.00 0 8459 57 10 46 1 37
CRW_01603 0.41 0.46 0.38 17 7095 29 6 22 1 20
CRW_01617 0.20 0.24 0.17 9 7087 45 7 37 1 28
CRW_01625 0.43 0.49 0.38 18 7093 31 7 22 2 19
PDB_00070 0.25 0.29 0.23 7 2819 24 4 20 0 17
PDB_00571 -0.01 0.00 0.00 0 3286 36 6 29 1 25
PDB_00828 0.30 0.33 0.28 9 2453 23 0 23 0 18
PDB_01236 0.31 0.33 0.30 18 11568 43 3 39 1 36
RFA_00416 0.94 1.00 0.88 15 1468 6 2 0 4 0
RFA_00434 0.84 1.00 0.71 15 1410 8 6 0 2 0
RFA_00436 0.86 1.00 0.75 15 1411 7 5 0 2 0
RFA_00442 0.94 1.00 0.88 15 1414 4 2 0 2 0
RFA_00664 -0.01 0.00 0.00 0 978 13 0 12 1 14
RFA_00674 0.12 0.14 0.13 2 1112 15 0 14 1 12
RFA_00675 0.28 0.29 0.29 4 976 10 1 9 0 10
RFA_00677 0.62 0.64 0.60 9 975 10 0 6 4 5
RFA_00717 0.64 0.64 0.64 9 889 5 2 3 0 5
RFA_00730 0.38 0.42 0.36 5 889 10 3 6 1 7
RFA_00763 0.38 0.42 0.36 5 889 10 3 6 1 7
RFA_00765 0.39 0.42 0.38 5 890 9 2 6 1 7
SPR_00066 0.47 0.57 0.39 12 2819 20 4 15 1 9
SPR_00314 0.47 0.57 0.39 12 2895 21 9 10 2 9
SPR_00333 0.25 0.33 0.21 7 2741 27 10 17 0 14
SPR_00353 0.64 0.81 0.52 17 2817 16 8 8 0 4
SPR_00452 0.27 0.33 0.23 7 2820 24 7 16 1 14
SPR_00456 0.49 0.57 0.43 12 2822 19 5 11 3 9
SPR_00476 0.47 0.52 0.42 11 2749 17 4 11 2 10
SPR_00496 0.47 0.57 0.40 12 2745 22 7 11 4 9
SPR_00497 0.27 0.33 0.23 7 2745 23 5 18 0 14
SPR_00502 0.27 0.33 0.23 7 2896 26 2 21 3 14
SPR_00509 0.23 0.30 0.19 6 2895 25 8 17 0 14
SPR_00512 0.61 0.75 0.50 15 2896 15 6 9 0 5
SPR_00557 0.42 0.52 0.34 11 2818 22 8 13 1 10
SPR_00868 0.49 0.57 0.43 12 2898 19 5 11 3 9
SPR_00957 0.63 0.76 0.53 16 2973 15 7 7 1 5
SPR_01040 0.15 0.19 0.13 4 2744 27 4 23 0 17
SRP_00038 0.23 0.27 0.20 9 5005 36 1 35 0 24
SRP_00046 0.33 0.38 0.29 12 4712 30 3 26 1 20
SRP_00103 0.00 0.00 0.00 0 45319 132 14 118 0 102
SRP_00170 0.29 0.36 0.25 9 4059 28 4 23 1 16
SRP_00194 0.27 0.33 0.23 7 3209 27 5 19 3 14
SRP_00200 0.41 0.47 0.35 17 6855 31 4 27 0 19
SRP_00233 0.25 0.30 0.22 10 5106 35 4 31 0 23
SRP_00243 0.47 0.55 0.40 17 5109 25 7 18 0 14
SRP_00244 0.38 0.44 0.34 17 6853 33 2 31 0 22
SRP_00266 0.55 0.66 0.46 19 4615 22 8 14 0 10
SRP_00269 0.46 0.52 0.43 17 5010 24 6 17 1 16
SRP_00273 0.36 0.40 0.33 16 6737 34 6 27 1 24
SRP_00303 0.36 0.41 0.33 13 6630 27 3 24 0 19
SRP_00317 0.14 0.16 0.12 16 45018 116 16 100 0 82
SRP_00333 0.20 0.24 0.19 8 5108 35 3 32 0 26
SRP_00337 0.42 0.46 0.38 42 35400 70 15 54 1 49
SRP_00338 0.52 0.56 0.49 20 5419 22 4 17 1 16
SRP_00342 0.20 0.24 0.17 6 3970 29 7 22 0 19
SRP_00358 0.32 0.37 0.28 13 6282 33 4 29 0 22
SRP_00383 -0.01 0.00 0.00 0 3205 35 9 26 0 24
TMR_00123 0.19 0.23 0.16 23 66283 126 20 104 2 78
TMR_00399 0.20 0.26 0.16 24 64833 130 38 85 7 70
TMR_00443 0.17 0.20 0.15 21 67018 126 24 98 4 83
TMR_00469 0.10 0.12 0.08 12 64469 145 27 112 6 88
TMR_00519 0.04 0.05 0.03 5 63046 141 33 106 2 90
TMR_00528 0.13 0.15 0.11 15 63051 131 20 104 7 82
TMR_00571 0.05 0.06 0.04 6 60577 149 19 124 6 93
TMR_00584 0.01 0.01 0.01 1 60922 159 33 119 7 96
TMR_00703 0.10 0.12 0.08 12 67376 140 26 114 0 87

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.