CompaRNA - on-line benchmarks of RNA structure prediction methods

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Metric	RNASampler(20)		RNAalifold(seed)
MCC	0.526	>	0.485
Average MCC ± 95% Confidence Intervals	0.595 ± 0.129	>	0.533 ± 0.116
Sensitivity	0.384	>	0.290
Positive Predictive Value	0.723	<	0.813
Total TP	357	>	270
Total TN	493814	<	493976
Total FP	165	>	70
Total FP CONTRA	16	>	14
Total FP INCONS	121	>	48
Total FP COMP	28	>	8
Total FN	573	<	660
P-value	2.08252958266e-08

Comparison of performance of RNASampler(20) and RNAalifold(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for RNASampler(20) and RNAalifold(seed)).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for RNASampler(20) and RNAalifold(seed)).
Comparison of average Matthews Correlation Coefficients (MCCs) for RNASampler(20) and RNAalifold(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for RNASampler(20) and RNAalifold(seed)).

Total Scores
MCC	0.526
Average MCC ± 95% Confidence Intervals	0.595 ± 0.129
Sensitivity	0.384
Positive Predictive Value	0.723
Nr of predictions	12

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
ASE_00064	RNaseP_bact_a links to Rfam database...	0.44	0.34	0.58	30	45399	23	1	21	1	59
ASE_00090	RNaseP_bact_a links to Rfam database...	0.54	0.40	0.74	40	55557	14	0	14	0	61
ASE_00135	RNaseP_bact_a links to Rfam database...	0.54	0.36	0.83	39	63143	16	0	8	8	70
ASE_00153	RNaseP_nuc links to Rfam database...	0.38	0.33	0.44	24	57576	38	7	23	8	49
ASE_00215	RNaseP_bact_a links to Rfam database...	0.38	0.23	0.62	23	48479	16	0	14	2	76
ASE_00328	RNaseP_bact_b links to Rfam database...	0.70	0.57	0.85	64	72696	14	5	6	3	48
ASE_00361	RNaseP_bact_a links to Rfam database...	0.34	0.21	0.55	27	75417	26	3	19	4	100
ASE_00441	RNaseP_bact_a links to Rfam database...	0.46	0.31	0.69	35	64210	16	0	16	0	77
PDB_00828	Purine links to Rfam database...	0.86	0.74	1.00	20	2465	0	0	0	0	7
PDB_00829	Purine links to Rfam database...	0.86	0.75	1.00	18	2260	0	0	0	0	6
PDB_01020	Purine links to Rfam database...	0.86	0.74	1.00	17	2261	1	0	0	1	6
PDB_01073	SAM links to Rfam database...	0.77	0.59	1.00	20	4351	1	0	0	1	14

Total Scores
MCC	0.485
Average MCC ± 95% Confidence Intervals	0.533 ± 0.116
Sensitivity	0.290
Positive Predictive Value	0.813
Nr of predictions	12

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
ASE_00064	RNaseP_bact_a links to Rfam database...	0.44	0.25	0.79	22	45423	6	1	5	0	67
ASE_00090	RNaseP_bact_a links to Rfam database...	0.42	0.23	0.79	23	55582	6	1	5	0	78
ASE_00135	RNaseP_bact_a links to Rfam database...	0.37	0.19	0.72	21	63161	8	1	7	0	88
ASE_00153	RNaseP_nuc links to Rfam database...	0.37	0.21	0.68	15	57608	7	0	7	0	58
ASE_00215	RNaseP_bact_a links to Rfam database...	0.36	0.17	0.74	17	48493	6	1	5	0	82
ASE_00328	RNaseP_bact_b links to Rfam database...	0.69	0.54	0.90	60	72704	12	1	6	5	52
ASE_00361	RNaseP_bact_a links to Rfam database...	0.36	0.17	0.76	22	75437	7	2	5	0	105
ASE_00441	RNaseP_bact_a links to Rfam database...	0.38	0.19	0.78	21	64234	7	1	5	1	91
PDB_00828	Purine links to Rfam database...	0.70	0.59	0.84	16	2466	3	2	1	0	11
PDB_00829	Purine links to Rfam database...	0.75	0.67	0.84	16	2259	3	2	1	0	8
PDB_01020	Purine links to Rfam database...	0.73	0.65	0.83	15	2260	4	2	1	1	8
PDB_01073	SAM links to Rfam database...	0.80	0.65	1.00	22	4349	1	0	0	1	12

Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.