Molecule image



Full name2′-O-methylcytidine
Short nameCm
New Nomenclature0C
RNAMods abbreviationB
Enzymes Nop1 (Saccharomyces cerevisiae)
RlmM (Escherichia coli)
RsmI (Escherichia coli)
Trm13 (Saccharomyces cerevisiae)
Trm7 (Saccharomyces cerevisiae)
TrmJ (Escherichia coli)
TrmJ (Sulfolobus acidocaldarius)
TrmL (Escherichia coli)
aTrm56 (Pyrococcus abyssi)
Found in phylogenyEubacteria, Eukaryota
Found in RNArRNA, snRNA, tRNA
PubChem ID150971
SMILES (no stereochemical information)C3(OC(CO)C(O)C(O(C))3)N1C=CC(N)=NC1(=O)

LC-MS Information

Sum formulaC10O5N3H15
Monoisotopic mass257.1012
Average mass257.2467
Product ions112
Normalized LC elution time *0,90 (Kellner 2014); 0,92 (Kellner 2014)
LC elution order/characteristicsbetween U and G (Kellner 2014, Kellner 2014)

* normalized to guanosine (G), measured with a RP C-18 column with acetonitrile/ammonium acetate as mobile phase.

LC-MS Publications

Title Authors Journal Details PubMed Id DOI
Profiling of RNA modifications by multiplexed stable isotope labelling. Kellner S, Neumann J, Rosenkranz D, Lebedeva S, Ketting RF, Zischler H, Schneider D, Helm M. Chem Commun (Camb). [details] 24567952 -
Quantitative analysis of ribonucleoside modifications in tRNA by HPLC-coupled mass spectrometry. Su D, Chan CT, Gu C, Lim KS, Chionh YH, McBee ME, Russell BS, Babu IR, Begley TJ, Dedon PC... Nat Protoc [details] 24625781 -
Absolute and relative quantification of RNA modifications via biosynthetic isotopomers. Kellner S, Ochel A, Thuring K, Spenkuch F, Neumann J, Sharma S, Entian KD, Schneider D, Helm M... Nucleic Acids Res [details] 25129236 -

3D Molecule representation

Download [.mol file for Cm]

Chemical groups contained

methyl groupmethyl at O2

Reactions producing 2′-O-methylcytidine


Reactions starting from 2′-O-methylcytidine


Occurrence in PDB structures

PDB-ID chain residue
1ehz A OMC/32
1evv A OMC/32
1fcw A OMC/32
1fcw B OMC/32
1fcw C OMC/32
1fcw D OMC/32
1fcw E OMC/32
1gix B OMC/32
1gix C OMC/32
1jgo B OMC/32
1jgo C OMC/32
1jgp B OMC/32
1jgp C OMC/32
1jgq B OMC/32
1jgq C OMC/32
1luu A OMC/32
1lux A OMC/32
1mj1 D OMC/32
1mj1 C OMC/32
1ml5 B OMC/32
1nao B OMC/12
1nao B OMC/17
1ob2 B OMC/32
1ob5 B OMC/32
1ob5 D OMC/32
1ob5 F OMC/32
1pbl A OMC/1
1pbl A OMC/3
1pbl A OMC/5
1pbl B OMC/7
1pbl B OMC/9
1pbl B OMC/11
1sz1 E OMC/32
1sz1 F OMC/32
1tn2 OMC/32
1tra OMC/32
1ttt D OMC/32
1ttt E OMC/32
1ttt F OMC/32
2fmt C OMC/32
2fmt D OMC/32
2goz B OMC/6
486d A OMC/32
4tna OMC/32
4tra OMC/32
6tna OMC/32

Last modification of this entry: Oct. 6, 2017

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