Molecule image

ges2U

Summary

Full name2-geranylthiouridine
Short nameges2U
New Nomenclature21U
RNAMods abbreviationΓ
Enzymes MnmH (Escherichia coli)
Found in phylogenyEubacteria
Found in RNA
SMILESC/C(C)=C\CCC(\C)=C\CSC1=NC(=O)C=CN1[C@@H]2O[C@H](CO)[C@H](O)C2O
SMILES (no stereochemical information)C/C(C)=C\CCC(\C)=C\CSC1=NC(=O)C=CN1[C@@H]2O[C@H](CO)[C@H](O)C2O

LC-MS Information

Sum formulaC19H28N2O5S
Monoisotopic mass396.1719
Average mass396.5078
[M+H]+397.1797
Product ions265
Normalized LC elution time * not available
LC elution order/characteristics not available

* normalized to guanosine (G), measured with a RP C-18 column with acetonitrile/ammonium acetate as mobile phase.

3D Molecule representation

Download [.mol file for ges2U]

Comments

An intermediate in the synthesis of cmnm5ges2U and mnm5ges2U.

Chemical groups contained

TypeSubtype
sulphurthio
hydrocarbongeranyl

Reactions producing 2-geranylthiouridine

Name
s2U:ges2U

Reactions starting from 2-geranylthiouridine

Name
ges2U:cmnm5ges2U
ges2U:nm5ges2U

Publications

Title Authors Journal Details PubMed Id DOI
Discovery and biological characterization of geranylated RNA in bacteria. Dumelin CE, Chen Y, Leconte AM, Chen YG, Liu DR... Nat Chem Biol [details] 22983156 -
A gain of function mutation in a protein mediates production of novel modified nucleosides. Chen P, Crain PF, Nasvall SJ, Pomerantz SC, Bjork GR... EMBO J [details] 15861125 -

Last modification of this entry: Oct. 6, 2017

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