Molecule image

s2U

Summary

Full name2-thiouridine
Short names2U
New Nomenclature2U
RNAMods abbreviation2
Enzymes MnmA (Escherichia coli)
Mtu1 (Saccharomyces cerevisiae)
Ncs2 (Saccharomyces cerevisiae)
Ncs6 (Saccharomyces cerevisiae)
TrmU (Homo sapiens)
Found in phylogenyEubacteria, Eukaryota
Found in RNAtRNA
PubChem ID3036443
SMILESC3(OC(CO)C(O)C(O)3)N1C=CC(=O)NC1(=S)
SMILES (no stereochemical information)C3(OC(CO)C(O)C(O)3)N1C=CC(=O)NC1(=S)

LC-MS Information

Sum formulaC9O5N2H12S1
Monoisotopic mass260.0467
Average mass260.2694
[M+H]+261.0545
Product ions129
Normalized LC elution time *1,06 (Kellner 2014)
LC elution order/characteristicsbetween G and A (Kellner 2014)

* normalized to guanosine (G), measured with a RP C-18 column with acetonitrile/ammonium acetate as mobile phase.


LC-MS Publications

Title Authors Journal Details PubMed Id DOI
Absolute and relative quantification of RNA modifications via biosynthetic isotopomers. Kellner S, Ochel A, Thuring K, Spenkuch F, Neumann J, Sharma S, Entian KD, Schneider D, Helm M... Nucleic Acids Res [details] 25129236 -

3D Molecule representation

Download [.mol file for s2U]

Chemical groups contained

TypeSubtype
heavy atomsulfur

Reactions producing 2-thiouridine

Name
U:s2U

Reactions starting from 2-thiouridine

Name
s2U:se2U
s2U:nm5s2U
s2U:cmnm5s2U
s2U:tm5s2U
s2U:s2Um
s2U:ges2U

Occurrence in PDB structures

PDB-ID chain residue
2c4y R SUR/11
2c4y S SUR/11
2c4z R SUR/10
2c4z R SUR/11
2c4z S SUR/10
2c4z S SUR/11
2k7e B SUR/3

Last modification of this entry: Oct. 6, 2017

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