Molecule image
Summary
| Full name | 3-methylcytidine |
| Short name | m3C |
| New Nomenclature | 3C |
| RNAMods abbreviation | ' |
| Enzymes |
Trm140 (Saccharomyces cerevisiae) |
| Found in phylogeny | Eukaryota |
| Found in RNA | tRNA |
| PubChem ID | 159649 |
| SMILES | C[N+]1=C(N)C=CN([C@@H]2O[C@H](CO)[C@H](O)C2O)C1=O |
| SMILES (no stereochemical information) | C[N+]1=C(N)C=CN([C@@H]2O[C@H](CO)[C@H](O)C2O)C1=O |
LC-MS Information
| Sum formula | C10O5N3H15 |
| Monoisotopic mass | 257.1012 |
| Average mass | 257.2467 |
| [M+H]+ | 258.109 |
| Product ions | 126 |
| Normalized LC elution time * | 0,55 (Kellner 2014); 0,54 (Kellner 2014) |
| LC elution order/characteristics | between C and U (Kellner 2014, Kellner 2014) |
* normalized to guanosine (G), measured with a RP C-18 column with acetonitrile/ammonium acetate as mobile phase.
LC-MS Publications
| Title | Authors | Journal | Details | ||
|---|---|---|---|---|---|
| Profiling of RNA modifications by multiplexed stable isotope labelling. | Kellner S, Neumann J, Rosenkranz D, Lebedeva S, Ketting RF, Zischler H, Schneider D, Helm M. | Chem Commun (Camb). | [details] | 24567952 | - |
| Quantitative analysis of ribonucleoside modifications in tRNA by HPLC-coupled mass spectrometry. | Su D, Chan CT, Gu C, Lim KS, Chionh YH, McBee ME, Russell BS, Babu IR, Begley TJ, Dedon PC... | Nat Protoc | [details] | 24625781 | - |
| Absolute and relative quantification of RNA modifications via biosynthetic isotopomers. | Kellner S, Ochel A, Thuring K, Spenkuch F, Neumann J, Sharma S, Entian KD, Schneider D, Helm M... | Nucleic Acids Res | [details] | 25129236 | - |
3D Molecule representation
Download [.mol file for m3C]
Comments
m3C has a positive charge at neutral pH.
Chemical groups contained
| Type | Subtype |
|---|---|
| methyl group | methyl at aromatic N |
Reactions producing 3-methylcytidine
| Name |
|---|
| C:m3C |
Occurrence in PDB structures
| PDB-ID | chain | residue |
|---|---|---|
| 1b5k | A | EDC/6 |
| 1b60 | A | EDC/6 |
| 1b6x | A | EDC/6 |
| 1b6y | A | EDC/6 |
| 1n5c | A | EDC/21 |
Last modification of this entry: Oct. 6, 2017