Molecule image

cmnm5ges2U

Summary

Full name5-carboxymethylaminomethyl-2-geranylthiouridine
Short namecmnm5ges2U
New Nomenclature2151U
RNAMods abbreviationf
Enzymes MnmH (Escherichia coli)
Found in phylogenyEubacteria
Found in RNAtRNA
SMILESO=C(O)CNCC1=CN(C(=NC1=O)SC\C=C(/C)CC\C=C(/C)C)[C@@H]2O[C@H](CO)[C@H](O)C2O
SMILES (no stereochemical information)O=C(O)CNCC1=CN(C(=NC1=O)SC\C=C(/C)CC\C=C(/C)C)[C@@H]2O[C@H](CO)[C@H](O)C2O

LC-MS Information

Sum formulaC22H33N3O7S
Monoisotopic mass483.2039
Average mass483.586
[M+H]+484.2117
Product ions352
Normalized LC elution time * not available
LC elution order/characteristics not available

* normalized to guanosine (G), measured with a RP C-18 column with acetonitrile/ammonium acetate as mobile phase.

3D Molecule representation

Download [.mol file for cmnm5ges2U]

Comments

Present in position 34 in a small fraction of E. coli tRNAGlnUUG.

Chemical groups contained

TypeSubtype
aminoalkylcarboxymethylaminomethyl
sulphurthio
hydrocarbongeranyl

Reactions producing 5-carboxymethylaminomethyl-2-geranylthiouridine

Name
cmnm5s2U:cmnm5ges2U
ges2U:cmnm5ges2U

Reactions starting from 5-carboxymethylaminomethyl-2-geranylthiouridine

Name
cmnm5ges2U:nm5ges2U

Publications

Title Authors Journal Details PubMed Id DOI
Discovery and biological characterization of geranylated RNA in bacteria. Dumelin CE, Chen Y, Leconte AM, Chen YG, Liu DR... Nat Chem Biol [details] 22983156 -
A gain of function mutation in a protein mediates production of novel modified nucleosides. Chen P, Crain PF, Nasvall SJ, Pomerantz SC, Bjork GR... EMBO J [details] 15861125 -

Last modification of this entry: Oct. 6, 2017

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