Molecule image

m5s2U

Summary

Full name5-methyl-2-thiouridine
Short namem5s2U
New Nomenclature25U
RNAMods abbreviationF
Enzymes TrmU (Homo sapiens)
Found in phylogenyEukaryota
Found in RNAtRNA
PubChem ID3035361
SMILESCC1=CN(C(=S)NC1=O)[C@@H]2O[C@H](CO)[C@H](O)C2O
SMILES (no stereochemical information)CC1=CN(C(=S)NC1=O)[C@@H]2O[C@H](CO)[C@H](O)C2O

LC-MS Information

Sum formulaC10O5N2H14S1
Monoisotopic mass274.0623
Average mass274.2964
[M+H]+275.0701
Product ions143
Normalized LC elution time *1,36 (Kellner 2014)
LC elution order/characteristicsbetween G and A (Kellner 2014)

* normalized to guanosine (G), measured with a RP C-18 column with acetonitrile/ammonium acetate as mobile phase.


LC-MS Publications

Title Authors Journal Details PubMed Id DOI
Absolute and relative quantification of RNA modifications via biosynthetic isotopomers. Kellner S, Ochel A, Thuring K, Spenkuch F, Neumann J, Sharma S, Entian KD, Schneider D, Helm M... Nucleic Acids Res [details] 25129236 -

3D Molecule representation

Download [.mol file for m5s2U]

Chemical groups contained

TypeSubtype
heavy atomsulfur
methyl groupmethyl at aromatic C

Reactions producing 5-methyl-2-thiouridine

Name
m5U:m5s2U

Occurrence in PDB structures

PDB-ID chain residue
2axb A S2M/6
2axb B S2M/16

Last modification of this entry: Oct. 6, 2017

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