Molecule image

mnm5ges2U

Summary

Full name5-methylaminomethyl-2-geranylthiouridine
Short namemnm5ges2U
New Nomenclature21511U
RNAMods abbreviationh
Enzymes MnmH (Escherichia coli)
Found in phylogenyEubacteria
Found in RNAtRNA
SMILESC/C(C)=C\CCC(\C)=C\CSC1=NC(=O)C(CNC)=CN1[C@@H]2O[C@H](CO)[C@H](O)C2O
SMILES (no stereochemical information)C/C(C)=C\CCC(\C)=C\CSC1=NC(=O)C(CNC)=CN1[C@@H]2O[C@H](CO)[C@H](O)C2O

LC-MS Information

Sum formulaC21H33N3O5S
Monoisotopic mass439.2141
Average mass439.5762
[M+H]+440.2219
Product ions308
Normalized LC elution time * not available
LC elution order/characteristics not available

* normalized to guanosine (G), measured with a RP C-18 column with acetonitrile/ammonium acetate as mobile phase.

3D Molecule representation

Download [.mol file for mnm5ges2U]

Comments

Present in position 34 in about 2.8-6.7% of E. coli tRNALysUUU and tRNAGluUUC.

Chemical groups contained

TypeSubtype
aminoalkylaminomethyl
hydrocarbonmethyl
sulphurthio
hydrocarbongeranyl

Reactions producing 5-methylaminomethyl-2-geranylthiouridine

Name
mnm5s2U:mnm5ges2U
nm5ges2U:mnm5ges2U

Publications

Title Authors Journal Details PubMed Id DOI
Discovery and biological characterization of geranylated RNA in bacteria. Dumelin CE, Chen Y, Leconte AM, Chen YG, Liu DR... Nat Chem Biol [details] 22983156 -
A gain of function mutation in a protein mediates production of novel modified nucleosides. Chen P, Crain PF, Nasvall SJ, Pomerantz SC, Bjork GR... EMBO J [details] 15861125 -

Last modification of this entry: Oct. 6, 2017

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