Molecule image

m8A

Summary

Full name8-methyladenosine
Short namem8A
New Nomenclature8A
RNAMods abbreviationâ
Enzymes Cfr (Staphylococcus sciuri)
Found in phylogenyEubacteria
Found in RNArRNA
SMILESCC1=NC2=C(N)N=CN=C2[N]1C3OC(CO)C(O)C3O
SMILES (no stereochemical information)CC1=NC2=C(N)N=CN=C2[N]1C3OC(CO)C(O)C3O

LC-MS Information

Sum formulaC11O4N5H15
Monoisotopic mass281.1124
Average mass281.2719
[M+H]+282.1202
Product ions150
Normalized LC elution time * not available
LC elution order/characteristics not available

* normalized to guanosine (G), measured with a RP C-18 column with acetonitrile/ammonium acetate as mobile phase.

3D Molecule representation

Download [.mol file for m8A]

Comments

The methyltransferase Cfr making m8A, has only been found in Staphylococcus sciuri so far, but it has been investigated in E. coli by expression of Cfr from a plasmid coded gene. It methylates A2503 in E. coli 23S RNA to m8A.

Also see: Identification of 8-methyladenosine as the modification catalyzed by the radical SAM methyltransferase Cfr that confers antibiotic resistance in bacteria. Giessing AM, Jensen SS, Rasmussen A, Hansen LH, Gondela A, Long K, Vester B, Kirpekar F. RNA. 2009 Feb;15(2):327-36.
PMID: 19144912

Chemical groups contained

TypeSubtype
methyl groupmethyl at aromatic C

Reactions producing 8-methyladenosine

Name
A:m8A

Reactions starting from 8-methyladenosine

Name
m8A:m2,8A

Last modification of this entry: Oct. 6, 2017

Copyright © Genesilico - All rights reserved
If you have any advice or suggestions for corrections or improvements, please contact: Pietro Boccaletto