Molecule image



Full nameN2,N2-dimethylguanosine
Short namem2,2G
New Nomenclature22G
RNAMods abbreviationR
Enzymes Trm-G10 (Pyrococcus abyssi)
Trm1 (Saccharomyces cerevisiae)
Trm1 (Aquifex aeolicus)
Trm1 (Pyrococcus horikoshii)
Trm1 (Homo sapiens)
Found in phylogenyArchaea, Eubacteria, Eukaryota
Found in RNArRNA, tRNA
PubChem ID601633
SMILES (no stereochemical information)C3(OC(CO)C(O)C(O)3)N2C=NC1=C2N=C(N(C)(C))NC1=O

LC-MS Information

Sum formulaC12O5N5H17
Monoisotopic mass311.123
Average mass311.2982
Product ions180
Normalized LC elution time *1,62 (Kellner 2014)
LC elution order/characteristicsbetween A and m6A (Kellner 2014)

* normalized to guanosine (G), measured with a RP C-18 column with acetonitrile/ammonium acetate as mobile phase.

LC-MS Publications

Title Authors Journal Details PubMed Id DOI
Profiling of RNA modifications by multiplexed stable isotope labelling. Kellner S, Neumann J, Rosenkranz D, Lebedeva S, Ketting RF, Zischler H, Schneider D, Helm M. Chem Commun (Camb). [details] 24567952 -
Quantitative analysis of ribonucleoside modifications in tRNA by HPLC-coupled mass spectrometry. Su D, Chan CT, Gu C, Lim KS, Chionh YH, McBee ME, Russell BS, Babu IR, Begley TJ, Dedon PC... Nat Protoc [details] 24625781 -

3D Molecule representation

Download [.mol file for m2,2G]

Chemical groups contained

methyl groupmethyl at other N
methyl groupsecond methyl at other N

Reactions producing N2,N2-dimethylguanosine


Reactions starting from N2,N2-dimethylguanosine


Occurrence in PDB structures

PDB-ID chain residue
1ehz A M2G/26
1evv A M2G/26
1f7u B M2G/926
1f7v B M2G/926
1fcw A M2G/26
1fcw B M2G/26
1fcw C M2G/26
1fcw D M2G/26
1fcw E M2G/26
1gix B M2G/26
1gix C M2G/26
1jgo B M2G/26
1jgo C M2G/26
1jgp B M2G/26
1jgp C M2G/26
1jgq B M2G/26
1jgq C M2G/26
1mj1 D M2G/26
1mj1 C M2G/26
1ml5 B M2G/26
1ob2 B M2G/26
1ob5 B M2G/26
1ob5 D M2G/26
1ob5 F M2G/26
1sz1 E M2G/26
1sz1 F M2G/26
1tn2 M2G/26
1tra M2G/26
1ttt D M2G/26
1ttt E M2G/26
1ttt F M2G/26
1yfg M2G/26
2i1c y M2G/966
486d A G/26
486d C M2G/26
4tna M2G/26
4tra M2G/26
6tna M2G/26

Last modification of this entry: Oct. 6, 2017

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