Summary

Full name	N6-methyl-N6-threonylcarbamoyladenosine
Short name	m6t6A
New Nomenclature	662A
RNAMods abbreviation	E
Enzymes	TRMO (Homo sapiens) TrmO (Escherichia coli)
Found in phylogeny	Eubacteria
Found in RNA	tRNA
SMILES	O=C(O)C(NC(=O)N(C)c3ncnc2c3ncn2[C@@H]1O[C@H](CO)[C@H](O)C1O)C(C)O
SMILES (no stereochemical information)	O=C(O)C(NC(=O)N(C)c3ncnc2c3ncn2[C@@H]1O[C@H](CO)[C@H](O)C1O)C(C)O

LC-MS Information

Sum formula	C16O8N6H22
Monoisotopic mass	426.1499
Average mass	426.3868
[M+H]+	427.1577
Product ions	295
Normalized LC elution time *	1,93 (Kellner 2014)
LC elution order/characteristics	between A and m6A (Kellner 2014)

^* normalized to guanosine (G), measured with a RP C-18 column with acetonitrile/ammonium acetate as mobile phase.

LC-MS Publications

Title	Authors	Journal	Details	PubMed Id	DOI
Profiling of RNA modifications by multiplexed stable isotope labelling.	Kellner S, Neumann J, Rosenkranz D, Lebedeva S, Ketting RF, Zischler H, Schneider D, Helm M.	Chem Commun (Camb).	[details]	24567952	-

3D Molecule representation

Chemical groups contained

Type	Subtype
aminoacyl group	threonyl
methyl group	methyl at other N
other	carbamoyl

Reactions producing N6-methyl-N6-threonylcarbamoyladenosine

Name
t6A:m6t6A

Occurrence in PDB structures

PDB-ID	chain	residue
1qf6	B	AET/37

Last modification of this entry: Oct. 6, 2017

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