Molecule image

m6t6A

Summary

Full nameN6-methyl-N6-threonylcarbamoyladenosine
Short namem6t6A
New Nomenclature662A
RNAMods abbreviationE
Enzymes TRMO (Homo sapiens)
TrmO (Escherichia coli)
Found in phylogenyEubacteria
Found in RNAtRNA
SMILESO=C(O)C(NC(=O)N(C)c3ncnc2c3ncn2[C@@H]1O[C@H](CO)[C@H](O)C1O)C(C)O
SMILES (no stereochemical information)O=C(O)C(NC(=O)N(C)c3ncnc2c3ncn2[C@@H]1O[C@H](CO)[C@H](O)C1O)C(C)O

LC-MS Information

Sum formulaC16O8N6H22
Monoisotopic mass426.1499
Average mass426.3868
[M+H]+427.1577
Product ions295
Normalized LC elution time *1,93 (Kellner 2014)
LC elution order/characteristicsbetween A and m6A (Kellner 2014)

* normalized to guanosine (G), measured with a RP C-18 column with acetonitrile/ammonium acetate as mobile phase.


LC-MS Publications

Title Authors Journal Details PubMed Id DOI
Profiling of RNA modifications by multiplexed stable isotope labelling. Kellner S, Neumann J, Rosenkranz D, Lebedeva S, Ketting RF, Zischler H, Schneider D, Helm M. Chem Commun (Camb). [details] 24567952 -

3D Molecule representation

Download [.mol file for m6t6A]

Chemical groups contained

TypeSubtype
aminoacyl groupthreonyl
methyl groupmethyl at other N
othercarbamoyl

Reactions producing N6-methyl-N6-threonylcarbamoyladenosine

Name
t6A:m6t6A

Occurrence in PDB structures

PDB-ID chain residue
1qf6 B AET/37

Last modification of this entry: Oct. 6, 2017

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