Full name | N6-threonylcarbamoyladenosine |
Short name | t6A |
New Nomenclature | 62A |
RNAMods abbreviation | 6 |
Enzymes |
Sua5 (Saccharomyces cerevisiae) TsaD (Escherichia coli) |
Found in phylogeny | Eubacteria, Eukaryota |
Found in RNA | tRNA |
SMILES | CC(O)C(N)C(=O)NC(=O)Nc3ncnc2c3ncn2[C@@H]1O[C@H](CO)[C@H](O)C1O |
SMILES (no stereochemical information) | CC(O)C(N)C(=O)NC(=O)Nc3ncnc2c3ncn2[C@@H]1O[C@H](CO)[C@H](O)C1O |
Sum formula | C15O8N6H20 |
Monoisotopic mass | 412.1343 |
Average mass | 412.3598 |
[M+H]+ | 413.1421 |
Product ions | 281 |
Normalized LC elution time * | 1,62 (Kellner 2014) |
LC elution order/characteristics | between A and m6A (Kellner 2014) |
* normalized to guanosine (G), measured with a RP C-18 column with acetonitrile/ammonium acetate as mobile phase.
Title | Authors | Journal | Details | ||
---|---|---|---|---|---|
Profiling of RNA modifications by multiplexed stable isotope labelling. | Kellner S, Neumann J, Rosenkranz D, Lebedeva S, Ketting RF, Zischler H, Schneider D, Helm M. | Chem Commun (Camb). | [details] | 24567952 | - |
Quantitative analysis of ribonucleoside modifications in tRNA by HPLC-coupled mass spectrometry. | Su D, Chan CT, Gu C, Lim KS, Chionh YH, McBee ME, Russell BS, Babu IR, Begley TJ, Dedon PC... | Nat Protoc | [details] | 24625781 | - |
Download [.mol file for t6A]
Type | Subtype |
---|---|
aminoacyl group | threonyl |
other | carbamoyl |
Name |
---|
A:t6A |
ct6A:t6A |
Name |
---|
t6A:m6t6A |
t6A:ms2t6A |
t6A:ct6A |
PDB-ID | chain | residue |
---|---|---|
1feq | A | T6A/37 |
1fl8 | A | T6A/37 |
1xmo | X | T6A/37 |
1xmq | X | T6A/37 |
1yfg | T6A/37 | |
2g1g | A | T6A/11 |
Last modification of this entry: Oct. 6, 2017