Molecule image

mcmo5U

Summary

Full nameuridine 5-oxyacetic acid methyl ester
Short namemcmo5U
New Nomenclature503U
RNAMods abbreviationυ
Enzymes
Found in phylogenyEubacteria
Found in RNAtRNA
PubChem ID191808
SMILESC3(OC(CO)C(O)C(O)3)N1C=C(OCC(=O)OC)C(=O)NC1(=O)
SMILES (no stereochemical information)C3(OC(CO)C(O)C(O)3)N1C=C(OCC(=O)OC)C(=O)NC1(=O)

LC-MS Information

Sum formulaC12O9N2H16
Monoisotopic mass332.0856
Average mass332.2672
[M+H]+333.0934
Product ions183/201/297/315/129
Normalized LC elution time *1,47 (Kellner 2014)
LC elution order/characteristicsbetween A and m6A (Kellner 2014)

* normalized to guanosine (G), measured with a RP C-18 column with acetonitrile/ammonium acetate as mobile phase.


LC-MS Publications

Title Authors Journal Details PubMed Id DOI
Profiling of RNA modifications by multiplexed stable isotope labelling. Kellner S, Neumann J, Rosenkranz D, Lebedeva S, Ketting RF, Zischler H, Schneider D, Helm M. Chem Commun (Camb). [details] 24567952 -

3D Molecule representation

Download [.mol file for mcmo5U]

Comments

Unstable under usual methods of detection, not easily detectable (Glenn Bjork, personal communication). cmo5U (and mcmo5U) is a modification characteristic for gram negative bacteria (E. coli, Protebacteria). Gram positive bacteria (B. subtilis, Firmicutes) have mo5U in this position.

Chemical groups contained

TypeSubtype
othercarboxymethyl
othermethoxy
othermethylester

Reactions producing uridine 5-oxyacetic acid methyl ester

Name
cmo5U:mcmo5U

Reactions starting from uridine 5-oxyacetic acid methyl ester

Name
mcmo5U:mcmo5Um

Publications

Title Authors Journal Details PubMed Id DOI
The identification of the tRNA substrates for the supK tRNA methylase. Pope WT, Brown A, Reeves RH Nucleic Acids Res [details] 347399 -

Last modification of this entry: Oct. 6, 2017

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