CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of Carnac(20) - scored higher in this pairwise comparison

  4. Performance of Murlet(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for Carnac(20) & Murlet(seed) [.zip] - may take several seconds...


Overview

Metric Carnac(20) Murlet(seed)
MCC 0.632 > 0.587
Average MCC ± 95% Confidence Intervals 0.541 ± 0.162 < 0.587 ± 0.038
Sensitivity 0.424 > 0.377
Positive Predictive Value 0.950 > 0.921
Total TP 171 > 152
Total TN 33495 < 33510
Total FP 20 < 25
Total FP CONTRA 3 < 4
Total FP INCONS 6 < 9
Total FP COMP 11 < 12
Total FN 232 < 251
P-value 2.30549897711e-08

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Performance plots


  1. Comparison of performance of Carnac(20) and Murlet(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Carnac(20) and Murlet(seed)).

  2. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for Carnac(20) and Murlet(seed)).

  3. Comparison of average Matthews Correlation Coefficients (MCCs) for Carnac(20) and Murlet(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Carnac(20) and Murlet(seed)).

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Performance of Carnac(20) - scored higher in this pairwise comparison

1. Total counts & total scores for Carnac(20)

Total Base Pair Counts
Total TP 171
Total TN 33495
Total FP 20
Total FP CONTRA 3
Total FP INCONS 6
Total FP COMP 11
Total FN 232
Total Scores
MCC 0.632
Average MCC ± 95% Confidence Intervals 0.541 ± 0.162
Sensitivity 0.424
Positive Predictive Value 0.950
Nr of predictions 17

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2. Individual counts for Carnac(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2KDQ_B 0.77 0.60 1.00 6 168 0 0 0 0 4
2L94_A 0.00 0.00 0.00 0 357 0 0 0 0 18
2XKV_B 0.43 0.18 1.00 2 1833 1 0 0 1 9
2XXA_G 0.29 0.09 1.00 3 2042 0 0 0 0 32
3GX2_A 0.68 0.46 1.00 13 1436 0 0 0 0 15
3IVN_B 0.91 0.83 1.00 19 884 0 0 0 0 4
3JYX_4 0.76 0.58 1.00 7 4749 2 0 0 2 5
3LA5_A 0.91 0.84 1.00 21 933 0 0 0 0 4
3NPB_A 0.46 0.22 1.00 8 2270 3 0 0 3 29
3O58_3 0.60 0.36 1.00 8 4756 1 0 0 1 14
3PDR_A 0.75 0.58 0.97 29 4810 3 1 0 2 21
3RKF_A 0.91 0.83 1.00 20 846 0 0 0 0 4
3SD1_A 0.72 0.55 0.94 16 1516 1 0 1 0 13
4A1C_2 0.42 0.25 0.71 5 4509 3 0 2 1 15
4AOB_A 0.59 0.48 0.74 14 1418 6 2 3 1 15
4ENB_A 0.00 0.00 0.00 0 472 0 0 0 0 15
4ENC_A 0.00 0.00 0.00 0 496 0 0 0 0 15

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Performance of Murlet(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for Murlet(seed)

Total Base Pair Counts
Total TP 152
Total TN 33510
Total FP 25
Total FP CONTRA 4
Total FP INCONS 9
Total FP COMP 12
Total FN 251
Total Scores
MCC 0.587
Average MCC ± 95% Confidence Intervals 0.587 ± 0.038
Sensitivity 0.377
Positive Predictive Value 0.921
Nr of predictions 17

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2. Individual counts for Murlet(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2KDQ_B 0.54 0.30 1.00 3 171 0 0 0 0 7
2L94_A 0.57 0.39 0.88 7 349 2 0 1 1 11
2XKV_B 0.60 0.36 1.00 4 1831 2 0 0 2 7
2XXA_G 0.41 0.17 1.00 6 2039 0 0 0 0 29
3GX2_A 0.70 0.50 1.00 14 1435 1 0 0 1 14
3IVN_B 0.62 0.52 0.75 12 887 4 2 2 0 11
3JYX_4 0.50 0.25 1.00 3 4753 4 0 0 4 9
3LA5_A 0.67 0.56 0.82 14 937 3 1 2 0 11
3NPB_A 0.59 0.35 1.00 13 2265 2 0 0 2 24
3O58_3 0.52 0.27 1.00 6 4758 1 0 0 1 16
3PDR_A 0.53 0.28 1.00 14 4826 0 0 0 0 36
3RKF_A 0.62 0.50 0.80 12 851 3 1 2 0 12
3SD1_A 0.56 0.38 0.85 11 1520 2 0 2 0 18
4A1C_2 0.59 0.35 1.00 7 4509 0 0 0 0 13
4AOB_A 0.69 0.48 1.00 14 1423 1 0 0 1 15
4ENB_A 0.63 0.40 1.00 6 466 0 0 0 0 9
4ENC_A 0.63 0.40 1.00 6 490 0 0 0 0 9

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.