CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of Carnac(20) - scored higher in this pairwise comparison

  4. Performance of NanoFolder - scored lower in this pairwise comparison

  5. Compile and download dataset for Carnac(20) & NanoFolder [.zip] - may take several seconds...


Overview

Metric Carnac(20) NanoFolder
MCC 0.603 > 0.389
Average MCC ± 95% Confidence Intervals 0.451 ± 0.537 > 0.405 ± 0.473
Sensitivity 0.455 < 0.475
Positive Predictive Value 0.807 > 0.331
Total TP 46 < 48
Total TN 9155 > 9067
Total FP 14 < 114
Total FP CONTRA 2 < 33
Total FP INCONS 9 < 64
Total FP COMP 3 < 17
Total FN 55 > 53
P-value 0.0

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Performance plots


  1. Comparison of performance of Carnac(20) and NanoFolder. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Carnac(20) and NanoFolder).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for Carnac(20) and NanoFolder. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Carnac(20) and NanoFolder).

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Performance of Carnac(20) - scored higher in this pairwise comparison

1. Total counts & total scores for Carnac(20)

Total Base Pair Counts
Total TP 46
Total TN 9155
Total FP 14
Total FP CONTRA 2
Total FP INCONS 9
Total FP COMP 3
Total FN 55
Total Scores
MCC 0.603
Average MCC ± 95% Confidence Intervals 0.451 ± 0.537
Sensitivity 0.455
Positive Predictive Value 0.807
Nr of predictions 4

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2. Individual counts for Carnac(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
4A1C_2 0.42 0.25 0.71 5 4509 3 0 2 1 15
4A1C_3 0.79 0.73 0.87 27 2732 5 0 4 1 10
4AOB_A 0.59 0.48 0.74 14 1418 6 2 3 1 15
4ENC_A 0.00 0.00 0.00 0 496 0 0 0 0 15

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Performance of NanoFolder - scored lower in this pairwise comparison

1. Total counts & total scores for NanoFolder

Total Base Pair Counts
Total TP 48
Total TN 9067
Total FP 114
Total FP CONTRA 33
Total FP INCONS 64
Total FP COMP 17
Total FN 53
Total Scores
MCC 0.389
Average MCC ± 95% Confidence Intervals 0.405 ± 0.473
Sensitivity 0.475
Positive Predictive Value 0.331
Nr of predictions 4

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2. Individual counts for NanoFolder [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
4A1C_2 -0.01 0.00 0.00 0 4469 61 18 29 14 20
4A1C_3 0.58 0.68 0.51 25 2714 24 9 15 0 12
4AOB_A 0.39 0.41 0.39 12 1406 20 4 15 1 17
4ENC_A 0.66 0.73 0.61 11 478 9 2 5 2 4

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.