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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of CentroidAlifold(20) - scored higher in this pairwise comparison

  4. Performance of CRWrnafold - scored lower in this pairwise comparison

  5. Compile and download dataset for CentroidAlifold(20) & CRWrnafold [.zip] - may take several seconds...


Overview

Metric CentroidAlifold(20) CRWrnafold
MCC 0.819 > 0.668
Average MCC ± 95% Confidence Intervals 0.779 ± 0.206 > 0.692 ± 0.219
Sensitivity 0.726 > 0.683
Positive Predictive Value 0.930 > 0.663
Total TP 119 > 112
Total TN 12246 > 12205
Total FP 17 < 83
Total FP CONTRA 3 < 18
Total FP INCONS 6 < 39
Total FP COMP 8 < 26
Total FN 45 < 52
P-value 0.0

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Performance plots


  1. Comparison of performance of CentroidAlifold(20) and CRWrnafold. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for CentroidAlifold(20) and CRWrnafold).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for CentroidAlifold(20) and CRWrnafold. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for CentroidAlifold(20) and CRWrnafold).

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Performance of CentroidAlifold(20) - scored higher in this pairwise comparison

1. Total counts & total scores for CentroidAlifold(20)

Total Base Pair Counts
Total TP 119
Total TN 12246
Total FP 17
Total FP CONTRA 3
Total FP INCONS 6
Total FP COMP 8
Total FN 45
Total Scores
MCC 0.819
Average MCC ± 95% Confidence Intervals 0.779 ± 0.206
Sensitivity 0.726
Positive Predictive Value 0.930
Nr of predictions 7

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2. Individual counts for CentroidAlifold(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3AMU_B 1.00 1.00 1.00 19 1138 2 0 0 2 0
3SD1_A 0.85 0.76 0.96 22 1510 1 0 1 0 7
4A1C_3 0.93 0.92 0.94 34 2727 4 0 2 2 3
4A1C_2 0.33 0.25 0.45 5 4505 8 3 3 2 15
4AOB_A 0.89 0.79 1.00 23 1414 2 0 0 2 6
4ENB_A 0.77 0.60 1.00 9 463 0 0 0 0 6
4ENC_A 0.68 0.47 1.00 7 489 0 0 0 0 8

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Performance of CRWrnafold - scored lower in this pairwise comparison

1. Total counts & total scores for CRWrnafold

Total Base Pair Counts
Total TP 112
Total TN 12205
Total FP 83
Total FP CONTRA 18
Total FP INCONS 39
Total FP COMP 26
Total FN 52
Total Scores
MCC 0.668
Average MCC ± 95% Confidence Intervals 0.692 ± 0.219
Sensitivity 0.683
Positive Predictive Value 0.663
Nr of predictions 7

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2. Individual counts for CRWrnafold [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3AMU_B 0.77 0.79 0.75 15 1137 8 0 5 3 4
3SD1_A 0.63 0.66 0.61 19 1502 12 6 6 0 10
4A1C_3 0.85 0.84 0.86 31 2727 7 0 5 2 6
4A1C_2 0.19 0.25 0.15 5 4483 44 8 20 16 15
4AOB_A 0.71 0.69 0.74 20 1410 8 4 3 1 9
4ENB_A 0.85 0.73 1.00 11 461 2 0 0 2 4
4ENC_A 0.85 0.73 1.00 11 485 2 0 0 2 4

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.