CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of ContextFold - scored higher in this pairwise comparison

  4. Performance of Carnac(20) - scored lower in this pairwise comparison

  5. Compile and download dataset for ContextFold & Carnac(20) [.zip] - may take several seconds...


Overview

Metric ContextFold Carnac(20)
MCC 0.698 > 0.562
Average MCC ± 95% Confidence Intervals 0.668 ± 0.320 > 0.361 ± 0.441
Sensitivity 0.638 > 0.397
Positive Predictive Value 0.771 < 0.807
Total TP 74 > 46
Total TN 9588 < 9627
Total FP 37 > 14
Total FP CONTRA 6 > 2
Total FP INCONS 16 > 9
Total FP COMP 15 > 3
Total FN 42 < 70
P-value 0.0

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Performance plots


  1. Comparison of performance of ContextFold and Carnac(20). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for ContextFold and Carnac(20)).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for ContextFold and Carnac(20). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for ContextFold and Carnac(20)).

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Performance of ContextFold - scored higher in this pairwise comparison

1. Total counts & total scores for ContextFold

Total Base Pair Counts
Total TP 74
Total TN 9588
Total FP 37
Total FP CONTRA 6
Total FP INCONS 16
Total FP COMP 15
Total FN 42
Total Scores
MCC 0.698
Average MCC ± 95% Confidence Intervals 0.668 ± 0.320
Sensitivity 0.638
Positive Predictive Value 0.771
Nr of predictions 5

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2. Individual counts for ContextFold [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
4A1C_2 0.26 0.25 0.28 5 4498 26 3 10 13 15
4A1C_3 0.96 0.92 1.00 34 2729 1 0 0 1 3
4AOB_A 0.62 0.59 0.68 17 1412 9 2 6 1 12
4ENB_A 0.77 0.60 1.00 9 463 0 0 0 0 6
4ENC_A 0.73 0.60 0.90 9 486 1 1 0 0 6

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Performance of Carnac(20) - scored lower in this pairwise comparison

1. Total counts & total scores for Carnac(20)

Total Base Pair Counts
Total TP 46
Total TN 9627
Total FP 14
Total FP CONTRA 2
Total FP INCONS 9
Total FP COMP 3
Total FN 70
Total Scores
MCC 0.562
Average MCC ± 95% Confidence Intervals 0.361 ± 0.441
Sensitivity 0.397
Positive Predictive Value 0.807
Nr of predictions 5

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2. Individual counts for Carnac(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
4A1C_2 0.42 0.25 0.71 5 4509 3 0 2 1 15
4A1C_3 0.79 0.73 0.87 27 2732 5 0 4 1 10
4AOB_A 0.59 0.48 0.74 14 1418 6 2 3 1 15
4ENB_A 0.00 0.00 0.00 0 472 0 0 0 0 15
4ENC_A 0.00 0.00 0.00 0 496 0 0 0 0 15

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.