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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of ContextFold - scored higher in this pairwise comparison

  4. Performance of Mastr(20) - scored lower in this pairwise comparison

  5. Compile and download dataset for ContextFold & Mastr(20) [.zip] - may take several seconds...


Overview

Metric ContextFold Mastr(20)
MCC 0.698 > 0.581
Average MCC ± 95% Confidence Intervals 0.668 ± 0.320 > 0.461 ± 0.392
Sensitivity 0.638 > 0.431
Positive Predictive Value 0.771 < 0.794
Total TP 74 > 50
Total TN 9588 < 9621
Total FP 37 > 17
Total FP CONTRA 6 > 1
Total FP INCONS 16 > 12
Total FP COMP 15 > 4
Total FN 42 < 66
P-value 0.0

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Performance plots


  1. Comparison of performance of ContextFold and Mastr(20). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for ContextFold and Mastr(20)).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for ContextFold and Mastr(20). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for ContextFold and Mastr(20)).

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Performance of ContextFold - scored higher in this pairwise comparison

1. Total counts & total scores for ContextFold

Total Base Pair Counts
Total TP 74
Total TN 9588
Total FP 37
Total FP CONTRA 6
Total FP INCONS 16
Total FP COMP 15
Total FN 42
Total Scores
MCC 0.698
Average MCC ± 95% Confidence Intervals 0.668 ± 0.320
Sensitivity 0.638
Positive Predictive Value 0.771
Nr of predictions 5

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2. Individual counts for ContextFold [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
4A1C_2 0.26 0.25 0.28 5 4498 26 3 10 13 15
4A1C_3 0.96 0.92 1.00 34 2729 1 0 0 1 3
4AOB_A 0.62 0.59 0.68 17 1412 9 2 6 1 12
4ENB_A 0.77 0.60 1.00 9 463 0 0 0 0 6
4ENC_A 0.73 0.60 0.90 9 486 1 1 0 0 6

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Performance of Mastr(20) - scored lower in this pairwise comparison

1. Total counts & total scores for Mastr(20)

Total Base Pair Counts
Total TP 50
Total TN 9621
Total FP 17
Total FP CONTRA 1
Total FP INCONS 12
Total FP COMP 4
Total FN 66
Total Scores
MCC 0.581
Average MCC ± 95% Confidence Intervals 0.461 ± 0.392
Sensitivity 0.431
Positive Predictive Value 0.794
Nr of predictions 5

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2. Individual counts for Mastr(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
4A1C_2 0.00 0.00 0.00 0 4516 0 0 0 0 20
4A1C_3 0.88 0.86 0.89 32 2727 7 0 4 3 5
4AOB_A 0.42 0.34 0.53 10 1418 10 1 8 1 19
4ENB_A 0.44 0.20 1.00 3 469 0 0 0 0 12
4ENC_A 0.57 0.33 1.00 5 491 0 0 0 0 10

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.