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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of ContextFold - scored higher in this pairwise comparison

  4. Performance of Multilign(20) - scored lower in this pairwise comparison

  5. Compile and download dataset for ContextFold & Multilign(20) [.zip] - may take several seconds...


Overview

Metric ContextFold Multilign(20)
MCC 0.698 > 0.583
Average MCC ± 95% Confidence Intervals 0.668 ± 0.320 > 0.556 ± 0.333
Sensitivity 0.638 > 0.578
Positive Predictive Value 0.771 > 0.598
Total TP 74 > 67
Total TN 9588 > 9572
Total FP 37 < 56
Total FP CONTRA 6 < 13
Total FP INCONS 16 < 32
Total FP COMP 15 > 11
Total FN 42 < 49
P-value 0.0

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Performance plots


  1. Comparison of performance of ContextFold and Multilign(20). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for ContextFold and Multilign(20)).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for ContextFold and Multilign(20). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for ContextFold and Multilign(20)).

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Performance of ContextFold - scored higher in this pairwise comparison

1. Total counts & total scores for ContextFold

Total Base Pair Counts
Total TP 74
Total TN 9588
Total FP 37
Total FP CONTRA 6
Total FP INCONS 16
Total FP COMP 15
Total FN 42
Total Scores
MCC 0.698
Average MCC ± 95% Confidence Intervals 0.668 ± 0.320
Sensitivity 0.638
Positive Predictive Value 0.771
Nr of predictions 5

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2. Individual counts for ContextFold [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
4A1C_3 0.96 0.92 1.00 34 2729 1 0 0 1 3
4A1C_2 0.26 0.25 0.28 5 4498 26 3 10 13 15
4AOB_A 0.62 0.59 0.68 17 1412 9 2 6 1 12
4ENB_A 0.77 0.60 1.00 9 463 0 0 0 0 6
4ENC_A 0.73 0.60 0.90 9 486 1 1 0 0 6

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Performance of Multilign(20) - scored lower in this pairwise comparison

1. Total counts & total scores for Multilign(20)

Total Base Pair Counts
Total TP 67
Total TN 9572
Total FP 56
Total FP CONTRA 13
Total FP INCONS 32
Total FP COMP 11
Total FN 49
Total Scores
MCC 0.583
Average MCC ± 95% Confidence Intervals 0.556 ± 0.333
Sensitivity 0.578
Positive Predictive Value 0.598
Nr of predictions 5

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2. Individual counts for Multilign(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
4A1C_3 0.88 0.86 0.89 32 2727 6 0 4 2 5
4A1C_2 0.20 0.25 0.16 5 4485 33 9 17 7 15
4AOB_A 0.59 0.55 0.64 16 1412 10 3 6 1 13
4ENB_A 0.39 0.33 0.50 5 462 6 0 5 1 10
4ENC_A 0.73 0.60 0.90 9 486 1 1 0 0 6

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.