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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of ContextFold - scored higher in this pairwise comparison

  4. Performance of RNAalifold(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for ContextFold & RNAalifold(seed) [.zip] - may take several seconds...


Overview

Metric ContextFold RNAalifold(seed)
MCC 0.570 > 0.542
Average MCC ± 95% Confidence Intervals 0.592 ± 0.249 > 0.515 ± 0.408
Sensitivity 0.515 > 0.392
Positive Predictive Value 0.641 < 0.760
Total TP 50 > 38
Total TN 7371 < 7399
Total FP 42 > 16
Total FP CONTRA 6 > 0
Total FP INCONS 22 > 12
Total FP COMP 14 > 4
Total FN 47 < 59
P-value 0.0

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Performance plots


  1. Comparison of performance of ContextFold and RNAalifold(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for ContextFold and RNAalifold(seed)).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for ContextFold and RNAalifold(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for ContextFold and RNAalifold(seed)).

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Performance of ContextFold - scored higher in this pairwise comparison

1. Total counts & total scores for ContextFold

Total Base Pair Counts
Total TP 50
Total TN 7371
Total FP 42
Total FP CONTRA 6
Total FP INCONS 22
Total FP COMP 14
Total FN 47
Total Scores
MCC 0.570
Average MCC ± 95% Confidence Intervals 0.592 ± 0.249
Sensitivity 0.515
Positive Predictive Value 0.641
Nr of predictions 5

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2. Individual counts for ContextFold [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A 0.58 0.56 0.63 10 512 6 0 6 0 8
4A1C_2 0.26 0.25 0.28 5 4498 26 3 10 13 15
4AOB_A 0.62 0.59 0.68 17 1412 9 2 6 1 12
4ENB_A 0.77 0.60 1.00 9 463 0 0 0 0 6
4ENC_A 0.73 0.60 0.90 9 486 1 1 0 0 6

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Performance of RNAalifold(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for RNAalifold(seed)

Total Base Pair Counts
Total TP 38
Total TN 7399
Total FP 16
Total FP CONTRA 0
Total FP INCONS 12
Total FP COMP 4
Total FN 59
Total Scores
MCC 0.542
Average MCC ± 95% Confidence Intervals 0.515 ± 0.408
Sensitivity 0.392
Positive Predictive Value 0.760
Nr of predictions 5

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2. Individual counts for RNAalifold(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A -0.03 0.00 0.00 0 516 12 0 12 0 18
4A1C_2 0.50 0.25 1.00 5 4511 2 0 0 2 15
4AOB_A 0.85 0.72 1.00 21 1416 2 0 0 2 8
4ENB_A 0.63 0.40 1.00 6 466 0 0 0 0 9
4ENC_A 0.63 0.40 1.00 6 490 0 0 0 0 9

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.