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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of ContextFold - scored higher in this pairwise comparison

  4. Performance of RSpredict(20) - scored lower in this pairwise comparison

  5. Compile and download dataset for ContextFold & RSpredict(20) [.zip] - may take several seconds...


Overview

Metric ContextFold RSpredict(20)
MCC 0.698 > 0.428
Average MCC ± 95% Confidence Intervals 0.668 ± 0.320 > 0.443 ± 0.186
Sensitivity 0.638 > 0.362
Positive Predictive Value 0.771 > 0.519
Total TP 74 > 42
Total TN 9588 < 9603
Total FP 37 < 48
Total FP CONTRA 6 < 13
Total FP INCONS 16 < 26
Total FP COMP 15 > 9
Total FN 42 < 74
P-value 0.0

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Performance plots


  1. Comparison of performance of ContextFold and RSpredict(20). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for ContextFold and RSpredict(20)).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for ContextFold and RSpredict(20). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for ContextFold and RSpredict(20)).

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Performance of ContextFold - scored higher in this pairwise comparison

1. Total counts & total scores for ContextFold

Total Base Pair Counts
Total TP 74
Total TN 9588
Total FP 37
Total FP CONTRA 6
Total FP INCONS 16
Total FP COMP 15
Total FN 42
Total Scores
MCC 0.698
Average MCC ± 95% Confidence Intervals 0.668 ± 0.320
Sensitivity 0.638
Positive Predictive Value 0.771
Nr of predictions 5

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2. Individual counts for ContextFold [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
4A1C_3 0.96 0.92 1.00 34 2729 1 0 0 1 3
4A1C_2 0.26 0.25 0.28 5 4498 26 3 10 13 15
4AOB_A 0.62 0.59 0.68 17 1412 9 2 6 1 12
4ENB_A 0.77 0.60 1.00 9 463 0 0 0 0 6
4ENC_A 0.73 0.60 0.90 9 486 1 1 0 0 6

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Performance of RSpredict(20) - scored lower in this pairwise comparison

1. Total counts & total scores for RSpredict(20)

Total Base Pair Counts
Total TP 42
Total TN 9603
Total FP 48
Total FP CONTRA 13
Total FP INCONS 26
Total FP COMP 9
Total FN 74
Total Scores
MCC 0.428
Average MCC ± 95% Confidence Intervals 0.443 ± 0.186
Sensitivity 0.362
Positive Predictive Value 0.519
Nr of predictions 5

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2. Individual counts for RSpredict(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
4A1C_3 0.60 0.49 0.75 18 2739 8 0 6 2 19
4A1C_2 0.25 0.30 0.21 6 4487 30 12 11 7 14
4AOB_A 0.33 0.21 0.55 6 1426 5 1 4 0 23
4ENB_A 0.54 0.40 0.75 6 464 2 0 2 0 9
4ENC_A 0.51 0.40 0.67 6 487 3 0 3 0 9

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.