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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of ContextFold - scored higher in this pairwise comparison

  4. Performance of TurboFold(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for ContextFold & TurboFold(seed) [.zip] - may take several seconds...


Overview

Metric ContextFold TurboFold(seed)
MCC 0.682 > 0.552
Average MCC ± 95% Confidence Intervals 0.653 ± 0.245 > 0.532 ± 0.378
Sensitivity 0.627 > 0.530
Positive Predictive Value 0.750 > 0.587
Total TP 84 > 71
Total TN 10100 > 10091
Total FP 43 < 65
Total FP CONTRA 6 < 15
Total FP INCONS 22 < 35
Total FP COMP 15 = 15
Total FN 50 < 63
P-value 0.0

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Performance plots


  1. Comparison of performance of ContextFold and TurboFold(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for ContextFold and TurboFold(seed)).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for ContextFold and TurboFold(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for ContextFold and TurboFold(seed)).

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Performance of ContextFold - scored higher in this pairwise comparison

1. Total counts & total scores for ContextFold

Total Base Pair Counts
Total TP 84
Total TN 10100
Total FP 43
Total FP CONTRA 6
Total FP INCONS 22
Total FP COMP 15
Total FN 50
Total Scores
MCC 0.682
Average MCC ± 95% Confidence Intervals 0.653 ± 0.245
Sensitivity 0.627
Positive Predictive Value 0.750
Nr of predictions 6

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2. Individual counts for ContextFold [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A 0.58 0.56 0.63 10 512 6 0 6 0 8
4A1C_2 0.26 0.25 0.28 5 4498 26 3 10 13 15
4A1C_3 0.96 0.92 1.00 34 2729 1 0 0 1 3
4AOB_A 0.62 0.59 0.68 17 1412 9 2 6 1 12
4ENB_A 0.77 0.60 1.00 9 463 0 0 0 0 6
4ENC_A 0.73 0.60 0.90 9 486 1 1 0 0 6

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Performance of TurboFold(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for TurboFold(seed)

Total Base Pair Counts
Total TP 71
Total TN 10091
Total FP 65
Total FP CONTRA 15
Total FP INCONS 35
Total FP COMP 15
Total FN 63
Total Scores
MCC 0.552
Average MCC ± 95% Confidence Intervals 0.532 ± 0.378
Sensitivity 0.530
Positive Predictive Value 0.587
Nr of predictions 6

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2. Individual counts for TurboFold(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A -0.03 0.00 0.00 0 513 15 3 12 0 18
4A1C_2 0.20 0.25 0.17 5 4486 37 9 16 12 15
4A1C_3 0.86 0.84 0.89 31 2728 6 0 4 2 6
4AOB_A 0.67 0.59 0.77 17 1415 6 2 3 1 12
4ENB_A 0.77 0.60 1.00 9 463 0 0 0 0 6
4ENC_A 0.73 0.60 0.90 9 486 1 1 0 0 6

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.