CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of Contrafold - scored higher in this pairwise comparison

  4. Performance of Pknots - scored lower in this pairwise comparison

  5. Compile and download dataset for Contrafold & Pknots [.zip] - may take several seconds...


Overview

Metric Contrafold Pknots
MCC 0.798 > 0.740
Average MCC ± 95% Confidence Intervals 0.815 ± 0.050 > 0.768 ± 0.057
Sensitivity 0.805 > 0.763
Positive Predictive Value 0.799 > 0.726
Total TP 1521 > 1443
Total TN 102156 > 102072
Total FP 619 < 747
Total FP CONTRA 117 < 179
Total FP INCONS 265 < 365
Total FP COMP 237 > 203
Total FN 369 < 447
P-value 3.56938820447e-08

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Performance plots


  1. Comparison of performance of Contrafold and Pknots. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Contrafold and Pknots).

  2. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for Contrafold and Pknots).

  3. Comparison of average Matthews Correlation Coefficients (MCCs) for Contrafold and Pknots. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Contrafold and Pknots).

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Performance of Contrafold - scored higher in this pairwise comparison

1. Total counts & total scores for Contrafold

Total Base Pair Counts
Total TP 1521
Total TN 102156
Total FP 619
Total FP CONTRA 117
Total FP INCONS 265
Total FP COMP 237
Total FN 369
Total Scores
MCC 0.798
Average MCC ± 95% Confidence Intervals 0.815 ± 0.050
Sensitivity 0.805
Positive Predictive Value 0.799
Nr of predictions 116

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2. Individual counts for Contrafold [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2K5Z_A - 1.00 1.00 1.00 11 175 0 0 0 0 0
2K63_A - 1.00 1.00 1.00 9 159 2 0 0 2 0
2K66_A - 1.00 1.00 1.00 9 80 0 0 0 0 0
2KD8_A - 1.00 1.00 1.00 9 99 0 0 0 0 0
2KDQ_B 1.00 1.00 1.00 10 164 0 0 0 0 0
2KE6_A 1.00 1.00 1.00 18 449 1 0 0 1 0
2KEZ_A - 1.00 1.00 1.00 8 94 0 0 0 0 0
2KFC_A - 0.71 0.63 0.83 5 230 1 1 0 0 3
2KGP_A - 1.00 1.00 1.00 9 112 1 0 0 1 0
2KMJ_A - 1.00 1.00 1.00 11 157 0 0 0 0 0
2KPV_A - 1.00 1.00 1.00 13 200 0 0 0 0 0
2KRL_A - 0.91 0.87 0.95 20 2003 9 1 0 8 3
2KU0_A - 0.63 0.58 0.70 7 282 3 2 1 0 5
2KUR_A 1.00 1.00 1.00 19 448 0 0 0 0 0
2KUU_A 1.00 1.00 1.00 18 429 1 0 0 1 0
2KUV_A 1.00 1.00 1.00 19 420 0 0 0 0 0
2KUW_A 1.00 1.00 1.00 18 452 1 0 0 1 0
2KX8_A 1.00 1.00 1.00 16 355 0 0 0 0 0
2KXM_A - 1.00 1.00 1.00 8 141 0 0 0 0 0
2KZL_A - 1.00 1.00 1.00 13 507 5 0 0 5 0
2L1F_A 1.00 1.00 1.00 23 740 0 0 0 0 0
2L1F_B 1.00 1.00 1.00 24 767 0 0 0 0 0
2L2K_A - 1.00 1.00 1.00 17 332 0 0 0 0 0
2L3C_B - 1.00 1.00 1.00 14 225 0 0 0 0 0
2L3E_A - 1.00 1.00 1.00 12 228 1 0 0 1 0
2L3J_B 1.00 1.00 1.00 30 955 0 0 0 0 0
2L5Z_A - 1.00 1.00 1.00 9 102 0 0 0 0 0
2L94_A 0.94 0.94 0.94 17 339 2 0 1 1 1
2LA5_A - 0.77 0.71 0.83 5 269 3 0 1 2 2
2LBS_A - 1.00 1.00 1.00 14 193 0 0 0 0 0
2LC8_A 0.46 0.39 0.58 7 516 5 3 2 0 11
2LDL_A - 1.00 1.00 1.00 9 131 1 0 0 1 0
2LDT_A - 1.00 1.00 1.00 11 151 0 0 0 0 0
2LHP_A - 1.00 1.00 1.00 15 246 0 0 0 0 0
2LI4_A - 1.00 1.00 1.00 14 175 0 0 0 0 0
2LJJ_A - 1.00 1.00 1.00 7 123 3 0 0 3 0
2LK3_A - 1.00 1.00 1.00 9 91 0 0 0 0 0
2LKR_A - 0.88 0.90 0.87 26 2410 11 0 4 7 3
2LQZ_A - 1.00 1.00 1.00 8 124 2 0 0 2 0
2LWK_A - 1.00 1.00 1.00 11 196 1 0 0 1 0
2RP0_A - 0.84 0.71 1.00 5 111 0 0 0 0 2
2RPT_A - 1.00 1.00 1.00 7 65 0 0 0 0 0
2RRC_A - 1.00 1.00 1.00 7 68 0 0 0 0 0
2WRQ_Y 1.00 1.00 1.00 9 1143 14 0 0 14 0
2WW9_F - 0.68 0.75 0.67 6 103 4 1 2 1 2
2WW9_D - 0.63 0.40 1.00 4 737 5 0 0 5 6
2WW9_E - 0.00 0.00 0.00 0 172 0 0 0 0 5
2WWQ_V 1.00 1.00 1.00 19 1185 4 0 0 4 0
2XKV_B 0.64 0.73 0.57 8 1821 27 0 6 21 3
2XQD_Y 0.85 0.86 0.86 18 1108 4 0 3 1 3
2XXA_G 0.10 0.11 0.12 4 2012 30 2 27 1 31
2Y8W_B - 1.00 1.00 1.00 6 82 3 0 0 3 0
2Y9C_V - 0.79 0.83 0.75 15 886 8 0 5 3 3
2YIE_Z - 0.53 0.63 0.45 5 591 6 4 2 0 3
2YIE_X - 1.00 1.00 1.00 7 537 4 0 0 4 0
2ZY6_A - 0.69 0.78 0.64 7 265 5 2 2 1 2
2ZZM_B 0.80 0.80 0.80 12 1343 13 0 3 10 3
2ZZN_D 0.93 0.95 0.91 21 961 3 2 0 1 1
3A2K_C 0.49 0.55 0.46 12 1082 14 3 11 0 10
3A3A_A 0.97 0.93 1.00 28 1472 0 0 0 0 2
3ADB_C - 0.98 0.97 1.00 32 1787 0 0 0 0 1
3AKZ_H 0.44 0.50 0.40 10 1102 18 6 9 3 10
3AM1_B - 0.74 0.76 0.73 22 1436 8 3 5 0 7
3AMU_B 0.75 0.79 0.71 15 1136 9 0 6 3 4
3DW4_A - -0.03 0.00 0.00 0 136 6 1 3 2 6
3G4S_9 0.45 0.50 0.42 13 2705 24 6 12 6 13
3GCA_A - 0.76 0.71 0.83 5 152 1 1 0 0 2
3GX2_A 0.93 0.89 0.96 25 1423 2 1 0 1 3
3HAY_E - 1.00 1.00 1.00 14 910 7 0 0 7 0
3HJW_D - 1.00 1.00 1.00 16 593 2 0 0 2 0
3IAB_R - 1.00 1.00 1.00 12 373 4 0 0 4 0
3ID5_D - 0.66 0.60 0.75 3 225 6 0 1 5 2
3IVN_B 0.91 0.83 1.00 19 884 0 0 0 0 4
3IWN_A 0.86 0.79 0.96 22 1449 1 0 1 0 6
3IZF_C 0.89 0.91 0.86 32 2603 11 0 5 6 3
3J0L_a - 0.53 0.55 0.55 6 400 6 3 2 1 5
3J0L_8 - 1.00 1.00 1.00 7 69 0 0 0 0 0
3J0L_1 - 0.83 0.77 0.91 10 473 3 0 1 2 3
3J0L_h - 0.87 0.88 0.88 28 2108 6 0 4 2 4
3J0L_7 - -0.02 0.00 0.00 0 512 7 1 6 0 10
3J0L_g - 0.00 0.00 0.00 0 176 1 0 0 1 2
3J0L_2 - 0.28 0.31 0.28 8 2221 26 2 19 5 18
3J16_L 0.55 0.57 0.55 12 1137 10 3 7 0 9
3JYV_7 -0.02 0.00 0.00 0 1091 20 4 16 0 20
3JYX_4 0.39 0.58 0.27 7 4730 35 13 6 16 5
3JYX_3 0.33 0.47 0.24 7 2349 24 16 6 2 8
3KTW_C - 0.56 0.60 0.54 15 1752 20 2 11 7 10
3LA5_A 0.91 0.84 1.00 21 933 0 0 0 0 4
3NDB_M - 0.98 0.98 0.98 43 3670 6 0 1 5 1
3NKB_B - 0.63 0.68 0.59 13 713 9 0 9 0 6
3NMU_E - 1.00 1.00 1.00 3 213 3 0 0 3 0
3NPB_A 0.86 0.84 0.89 31 2243 9 1 3 5 6
3O58_2 0.92 0.94 0.91 29 2722 10 0 3 7 2
3O58_3 0.32 0.36 0.29 8 4736 21 7 13 1 14
3OVB_D - 1.00 1.00 1.00 11 215 1 0 0 1 0
3OVS_D - 1.00 1.00 1.00 12 204 0 0 0 0 0
3P22_G - 1.00 1.00 1.00 11 301 1 0 0 1 0
3PDR_A 0.83 0.86 0.80 43 4786 13 5 6 2 7
3R4F_A - 0.81 0.82 0.82 18 884 5 2 2 1 4
3R9X_C - 1.00 1.00 1.00 8 221 2 0 0 2 0
3RKF_A 0.87 0.83 0.91 20 844 2 2 0 0 4
3SD1_A 0.68 0.69 0.69 20 1504 9 5 4 0 9
3SIU_F - 0.87 0.88 0.88 7 137 1 0 1 0 1
3SN2_B 0.95 0.92 1.00 11 143 0 0 0 0 1
3TRZ_Z - 1.00 1.00 1.00 5 87 1 0 0 1 0
3TS0_U - 1.00 1.00 1.00 6 112 1 0 0 1 0
3TS2_V - 1.00 1.00 1.00 5 103 0 0 0 0 0
3U4M_B - 0.81 0.77 0.85 17 1256 5 0 3 2 5
3UZL_B 0.90 0.88 0.93 14 1278 8 0 1 7 2
3VJR_D - 1.00 1.00 1.00 12 239 0 0 0 0 0
4A1C_2 0.21 0.25 0.19 5 4489 33 9 13 11 15
4A1C_3 0.81 0.81 0.81 30 2726 10 0 7 3 7
4A4U_A - 1.00 1.00 1.00 9 96 0 0 0 0 0
4AOB_A 0.53 0.52 0.56 15 1410 13 3 9 1 14
4ENB_A 0.85 0.73 1.00 11 461 1 0 0 1 4
4ENC_A 0.85 0.73 1.00 11 485 1 0 0 1 4

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Performance of Pknots - scored lower in this pairwise comparison

1. Total counts & total scores for Pknots

Total Base Pair Counts
Total TP 1443
Total TN 102072
Total FP 747
Total FP CONTRA 179
Total FP INCONS 365
Total FP COMP 203
Total FN 447
Total Scores
MCC 0.740
Average MCC ± 95% Confidence Intervals 0.768 ± 0.057
Sensitivity 0.763
Positive Predictive Value 0.726
Nr of predictions 116

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2. Individual counts for Pknots [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2K5Z_A - 0.90 0.82 1.00 9 177 0 0 0 0 2
2K63_A - 1.00 1.00 1.00 9 159 0 0 0 0 0
2K66_A - 1.00 1.00 1.00 9 80 0 0 0 0 0
2KD8_A - 1.00 1.00 1.00 9 99 0 0 0 0 0
2KDQ_B 1.00 1.00 1.00 10 164 0 0 0 0 0
2KE6_A 1.00 1.00 1.00 18 449 1 0 0 1 0
2KEZ_A - 1.00 1.00 1.00 8 94 0 0 0 0 0
2KFC_A - 0.17 0.25 0.17 2 224 10 3 7 0 6
2KGP_A - 0.81 0.67 1.00 6 115 1 0 0 1 3
2KMJ_A - 1.00 1.00 1.00 11 157 0 0 0 0 0
2KPV_A - 0.96 0.92 1.00 12 201 0 0 0 0 1
2KRL_A - 0.79 0.83 0.76 19 1999 13 5 1 7 4
2KU0_A - -0.04 0.00 0.00 0 282 10 0 10 0 12
2KUR_A 1.00 1.00 1.00 19 448 0 0 0 0 0
2KUU_A 1.00 1.00 1.00 18 429 1 0 0 1 0
2KUV_A 1.00 1.00 1.00 19 420 0 0 0 0 0
2KUW_A 1.00 1.00 1.00 18 452 1 0 0 1 0
2KX8_A 1.00 1.00 1.00 16 355 0 0 0 0 0
2KXM_A - -0.04 0.00 0.00 0 144 5 0 5 0 8
2KZL_A - 0.66 0.69 0.64 9 506 6 2 3 1 4
2L1F_A 1.00 1.00 1.00 23 740 0 0 0 0 0
2L1F_B 1.00 1.00 1.00 24 767 0 0 0 0 0
2L2K_A - 1.00 1.00 1.00 17 332 0 0 0 0 0
2L3C_B - 0.96 0.93 1.00 13 226 0 0 0 0 1
2L3E_A - 1.00 1.00 1.00 12 228 1 0 0 1 0
2L3J_B 1.00 1.00 1.00 30 955 0 0 0 0 0
2L5Z_A - 1.00 1.00 1.00 9 102 0 0 0 0 0
2L94_A 0.94 0.94 0.94 17 339 2 0 1 1 1
2LA5_A - 0.77 0.71 0.83 5 269 1 0 1 0 2
2LBS_A - 1.00 1.00 1.00 14 193 0 0 0 0 0
2LC8_A 0.83 0.83 0.83 15 510 3 2 1 0 3
2LDL_A - 1.00 1.00 1.00 9 131 1 0 0 1 0
2LDT_A - 1.00 1.00 1.00 11 151 0 0 0 0 0
2LHP_A - 1.00 1.00 1.00 15 246 0 0 0 0 0
2LI4_A - 1.00 1.00 1.00 14 175 0 0 0 0 0
2LJJ_A - 1.00 1.00 1.00 7 123 3 0 0 3 0
2LK3_A - 1.00 1.00 1.00 9 91 0 0 0 0 0
2LKR_A - 0.48 0.55 0.43 16 2403 23 9 12 2 13
2LQZ_A - 1.00 1.00 1.00 8 124 2 0 0 2 0
2LWK_A - 0.38 0.27 0.60 3 202 3 0 2 1 8
2RP0_A - 0.87 1.00 0.78 7 107 2 2 0 0 0
2RPT_A - 1.00 1.00 1.00 7 65 0 0 0 0 0
2RRC_A - 0.92 0.86 1.00 6 69 0 0 0 0 1
2WRQ_Y 1.00 1.00 1.00 9 1143 13 0 0 13 0
2WW9_F - 0.68 0.75 0.67 6 103 4 1 2 1 2
2WW9_D - 0.52 0.60 0.46 6 728 13 5 2 6 4
2WW9_E - 0.79 0.80 0.80 4 167 3 0 1 2 1
2WWQ_V 0.29 0.32 0.29 6 1183 16 3 12 1 13
2XKV_B 0.21 0.27 0.17 3 1817 33 3 12 18 8
2XQD_Y 0.98 0.95 1.00 20 1109 1 0 0 1 1
2XXA_G 0.32 0.34 0.32 12 2008 26 1 24 1 23
2Y8W_B - 1.00 1.00 1.00 6 82 1 0 0 1 0
2Y9C_V - 0.70 0.67 0.75 12 890 6 0 4 2 6
2YIE_Z - -0.02 0.00 0.00 0 587 15 6 9 0 8
2YIE_X - 0.53 0.57 0.50 4 536 6 1 3 2 3
2ZY6_A - 0.66 0.78 0.58 7 264 5 3 2 0 2
2ZZM_B 0.18 0.20 0.19 3 1342 23 4 9 10 12
2ZZN_D 0.95 0.95 0.95 21 962 1 1 0 0 1
3A2K_C 0.50 0.55 0.48 12 1083 13 3 10 0 10
3A3A_A 0.97 0.93 1.00 28 1472 0 0 0 0 2
3ADB_C - 0.98 0.97 1.00 32 1787 0 0 0 0 1
3AKZ_H 1.00 1.00 1.00 20 1107 2 0 0 2 0
3AM1_B - 1.00 1.00 1.00 29 1437 0 0 0 0 0
3AMU_B 1.00 1.00 1.00 19 1138 3 0 0 3 0
3DW4_A - 0.91 0.83 1.00 5 135 0 0 0 0 1
3G4S_9 0.37 0.46 0.31 12 2697 27 14 13 0 14
3GCA_A - 0.66 0.57 0.80 4 153 3 0 1 2 3
3GX2_A 0.55 0.57 0.55 16 1420 14 4 9 1 12
3HAY_E - 1.00 1.00 1.00 14 910 6 0 0 6 0
3HJW_D - 1.00 1.00 1.00 16 593 3 0 0 3 0
3IAB_R - 1.00 1.00 1.00 12 373 4 0 0 4 0
3ID5_D - -0.02 0.00 0.00 0 224 5 1 4 0 5
3IVN_B 0.91 0.87 0.95 20 882 1 0 1 0 3
3IWN_A 0.22 0.21 0.25 6 1448 18 2 16 0 22
3IZF_C 0.89 0.91 0.86 32 2603 9 0 5 4 3
3J0L_a - 0.35 0.36 0.36 4 400 8 3 4 1 7
3J0L_8 - 1.00 1.00 1.00 7 69 0 0 0 0 0
3J0L_1 - 0.73 0.62 0.89 8 475 3 0 1 2 5
3J0L_h - 0.67 0.66 0.70 21 2110 11 4 5 2 11
3J0L_7 - 0.38 0.50 0.31 5 503 12 3 8 1 5
3J0L_g - -0.02 0.00 0.00 0 171 5 3 2 0 2
3J0L_2 - 0.44 0.46 0.43 12 2222 23 1 15 7 14
3J16_L 0.41 0.43 0.41 9 1137 13 1 12 0 12
3JYV_7 0.97 0.95 1.00 19 1092 2 0 0 2 1
3JYX_4 0.33 0.58 0.19 7 4720 41 22 7 12 5
3JYX_3 0.37 0.53 0.27 8 2348 26 17 5 4 7
3KTW_C - 0.63 0.68 0.59 17 1751 18 3 9 6 8
3LA5_A 0.94 0.88 1.00 22 932 0 0 0 0 3
3NDB_M - 0.92 0.93 0.91 41 3669 8 3 1 4 3
3NKB_B - 0.64 0.68 0.62 13 714 8 0 8 0 6
3NMU_E - 1.00 1.00 1.00 3 213 5 0 0 5 0
3NPB_A 0.84 0.81 0.88 30 2244 9 0 4 5 7
3O58_2 0.93 0.90 0.97 28 2725 3 0 1 2 3
3O58_3 0.32 0.45 0.24 10 4722 39 18 14 7 12
3OVB_D - 1.00 1.00 1.00 11 215 1 0 0 1 0
3OVS_D - 1.00 1.00 1.00 12 204 0 0 0 0 0
3P22_G - 1.00 1.00 1.00 11 301 0 0 0 0 0
3PDR_A 0.64 0.64 0.65 32 4791 19 4 13 2 18
3R4F_A - 1.00 1.00 1.00 22 884 1 0 0 1 0
3R9X_C - 0.87 0.88 0.88 7 221 5 0 1 4 1
3RKF_A 0.91 0.88 0.95 21 844 1 0 1 0 3
3SD1_A 0.78 0.76 0.81 22 1506 5 1 4 0 7
3SIU_F - 0.86 0.75 1.00 6 139 0 0 0 0 2
3SN2_B 0.95 0.92 1.00 11 143 0 0 0 0 1
3TRZ_Z - 1.00 1.00 1.00 5 87 1 0 0 1 0
3TS0_U - 1.00 1.00 1.00 6 112 1 0 0 1 0
3TS2_V - 1.00 1.00 1.00 5 103 0 0 0 0 0
3U4M_B - 0.33 0.36 0.32 8 1251 17 4 13 0 14
3UZL_B 1.00 1.00 1.00 16 1277 7 0 0 7 0
3VJR_D - 1.00 1.00 1.00 12 239 0 0 0 0 0
4A1C_2 0.33 0.40 0.29 8 4488 36 9 11 16 12
4A1C_3 0.28 0.30 0.28 11 2723 30 4 25 1 26
4A4U_A - 1.00 1.00 1.00 9 96 0 0 0 0 0
4AOB_A 0.19 0.21 0.21 6 1409 23 3 19 1 23
4ENB_A 1.00 1.00 1.00 15 457 2 0 0 2 0
4ENC_A 0.97 1.00 0.94 15 480 1 1 0 0 0

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.