CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of Contrafold - scored higher in this pairwise comparison

  4. Performance of RNAsubopt - scored lower in this pairwise comparison

  5. Compile and download dataset for Contrafold & RNAsubopt [.zip] - may take several seconds...


Overview

Metric Contrafold RNAsubopt
MCC 0.769 > 0.738
Average MCC ± 95% Confidence Intervals 0.808 ± 0.050 > 0.770 ± 0.057
Sensitivity 0.784 > 0.757
Positive Predictive Value 0.761 > 0.726
Total TP 1596 > 1542
Total TN 149937 > 149912
Total FP 763 < 846
Total FP CONTRA 179 < 185
Total FP INCONS 323 < 396
Total FP COMP 261 < 265
Total FN 440 < 494
P-value 3.56938820447e-08

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Performance plots


  1. Comparison of performance of Contrafold and RNAsubopt. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Contrafold and RNAsubopt).

  2. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for Contrafold and RNAsubopt).

  3. Comparison of average Matthews Correlation Coefficients (MCCs) for Contrafold and RNAsubopt. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Contrafold and RNAsubopt).

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Performance of Contrafold - scored higher in this pairwise comparison

1. Total counts & total scores for Contrafold

Total Base Pair Counts
Total TP 1596
Total TN 149937
Total FP 763
Total FP CONTRA 179
Total FP INCONS 323
Total FP COMP 261
Total FN 440
Total Scores
MCC 0.769
Average MCC ± 95% Confidence Intervals 0.808 ± 0.050
Sensitivity 0.784
Positive Predictive Value 0.761
Nr of predictions 118

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2. Individual counts for Contrafold [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2K5Z_A - 1.00 1.00 1.00 11 175 0 0 0 0 0
2K63_A - 1.00 1.00 1.00 9 159 2 0 0 2 0
2K66_A - 1.00 1.00 1.00 9 80 0 0 0 0 0
2KD8_A - 1.00 1.00 1.00 9 99 0 0 0 0 0
2KDQ_B 1.00 1.00 1.00 10 164 0 0 0 0 0
2KE6_A 1.00 1.00 1.00 18 449 1 0 0 1 0
2KEZ_A - 1.00 1.00 1.00 8 94 0 0 0 0 0
2KFC_A - 0.71 0.63 0.83 5 230 1 1 0 0 3
2KGP_A - 1.00 1.00 1.00 9 112 1 0 0 1 0
2KMJ_A - 1.00 1.00 1.00 11 157 0 0 0 0 0
2KPV_A - 1.00 1.00 1.00 13 200 0 0 0 0 0
2KRL_A - 0.91 0.87 0.95 20 2003 9 1 0 8 3
2KU0_A - 0.63 0.58 0.70 7 282 3 2 1 0 5
2KUR_A 1.00 1.00 1.00 19 448 0 0 0 0 0
2KUU_A 1.00 1.00 1.00 18 429 1 0 0 1 0
2KUV_A 1.00 1.00 1.00 19 420 0 0 0 0 0
2KUW_A 1.00 1.00 1.00 18 452 1 0 0 1 0
2KX8_A 1.00 1.00 1.00 16 355 0 0 0 0 0
2KXM_A - 1.00 1.00 1.00 8 141 0 0 0 0 0
2KZL_A - 1.00 1.00 1.00 13 507 5 0 0 5 0
2L1F_A 1.00 1.00 1.00 23 740 0 0 0 0 0
2L1F_B 1.00 1.00 1.00 24 767 0 0 0 0 0
2L2K_A - 1.00 1.00 1.00 17 332 0 0 0 0 0
2L3C_B - 1.00 1.00 1.00 14 225 0 0 0 0 0
2L3E_A - 1.00 1.00 1.00 12 228 1 0 0 1 0
2L3J_B 1.00 1.00 1.00 30 955 0 0 0 0 0
2L5Z_A - 1.00 1.00 1.00 9 102 0 0 0 0 0
2L94_A 0.94 0.94 0.94 17 339 2 0 1 1 1
2LA5_A - 0.77 0.71 0.83 5 269 3 0 1 2 2
2LBS_A - 1.00 1.00 1.00 14 193 0 0 0 0 0
2LC8_A 0.46 0.39 0.58 7 516 5 3 2 0 11
2LDL_A - 1.00 1.00 1.00 9 131 1 0 0 1 0
2LDT_A - 1.00 1.00 1.00 11 151 0 0 0 0 0
2LHP_A - 1.00 1.00 1.00 15 246 0 0 0 0 0
2LI4_A - 1.00 1.00 1.00 14 175 0 0 0 0 0
2LJJ_A - 1.00 1.00 1.00 7 123 3 0 0 3 0
2LK3_A - 1.00 1.00 1.00 9 91 0 0 0 0 0
2LKR_A - 0.88 0.90 0.87 26 2410 11 0 4 7 3
2LQZ_A - 1.00 1.00 1.00 8 124 2 0 0 2 0
2LWK_A - 1.00 1.00 1.00 11 196 1 0 0 1 0
2RP0_A - 0.84 0.71 1.00 5 111 0 0 0 0 2
2RPT_A - 1.00 1.00 1.00 7 65 0 0 0 0 0
2RRC_A - 1.00 1.00 1.00 7 68 0 0 0 0 0
2WRQ_Y 1.00 1.00 1.00 9 1143 14 0 0 14 0
2WW9_D - 0.63 0.40 1.00 4 737 5 0 0 5 6
2WW9_E - 0.00 0.00 0.00 0 172 0 0 0 0 5
2WW9_F - 0.68 0.75 0.67 6 103 4 1 2 1 2
2WWQ_V 1.00 1.00 1.00 19 1185 4 0 0 4 0
2XKV_B 0.64 0.73 0.57 8 1821 27 0 6 21 3
2XQD_Y 0.85 0.86 0.86 18 1108 4 0 3 1 3
2XXA_G 0.10 0.11 0.12 4 2012 30 2 27 1 31
2Y8W_B - 1.00 1.00 1.00 6 82 3 0 0 3 0
2Y9C_V - 0.79 0.83 0.75 15 886 8 0 5 3 3
2YIE_X - 1.00 1.00 1.00 7 537 4 0 0 4 0
2YIE_Z - 0.53 0.63 0.45 5 591 6 4 2 0 3
2ZY6_A - 0.69 0.78 0.64 7 265 5 2 2 1 2
2ZZM_B 0.80 0.80 0.80 12 1343 13 0 3 10 3
2ZZN_D 0.93 0.95 0.91 21 961 3 2 0 1 1
3A2K_C 0.49 0.55 0.46 12 1082 14 3 11 0 10
3A3A_A 0.97 0.93 1.00 28 1472 0 0 0 0 2
3ADB_C - 0.98 0.97 1.00 32 1787 0 0 0 0 1
3AKZ_H 0.44 0.50 0.40 10 1102 18 6 9 3 10
3AM1_B - 0.74 0.76 0.73 22 1436 8 3 5 0 7
3AMU_B 0.75 0.79 0.71 15 1136 9 0 6 3 4
3DW4_A - -0.03 0.00 0.00 0 136 6 1 3 2 6
3G4S_9 0.45 0.50 0.42 13 2705 24 6 12 6 13
3GCA_A - 0.76 0.71 0.83 5 152 1 1 0 0 2
3GX2_A 0.93 0.89 0.96 25 1423 2 1 0 1 3
3HAY_E - 1.00 1.00 1.00 14 910 7 0 0 7 0
3HJW_D - 1.00 1.00 1.00 16 593 2 0 0 2 0
3IAB_R - 1.00 1.00 1.00 12 373 4 0 0 4 0
3ID5_D - 0.66 0.60 0.75 3 225 6 0 1 5 2
3IVN_B 0.91 0.83 1.00 19 884 0 0 0 0 4
3IWN_A 0.86 0.79 0.96 22 1449 1 0 1 0 6
3IYQ_A 0.28 0.39 0.20 20 22341 95 44 35 16 31
3IZ4_A 0.57 0.58 0.57 55 25440 49 18 23 8 40
3IZF_C 0.89 0.91 0.86 32 2603 11 0 5 6 3
3J0L_h - 0.87 0.88 0.88 28 2108 6 0 4 2 4
3J0L_g - 0.00 0.00 0.00 0 176 1 0 0 1 2
3J0L_8 - 1.00 1.00 1.00 7 69 0 0 0 0 0
3J0L_a - 0.53 0.55 0.55 6 400 6 3 2 1 5
3J0L_2 - 0.28 0.31 0.28 8 2221 26 2 19 5 18
3J0L_1 - 0.83 0.77 0.91 10 473 3 0 1 2 3
3J0L_7 - -0.02 0.00 0.00 0 512 7 1 6 0 10
3J16_L 0.55 0.57 0.55 12 1137 10 3 7 0 9
3JYV_7 -0.02 0.00 0.00 0 1091 20 4 16 0 20
3JYX_3 0.33 0.47 0.24 7 2349 24 16 6 2 8
3JYX_4 0.39 0.58 0.27 7 4730 35 13 6 16 5
3KTW_C - 0.56 0.60 0.54 15 1752 20 2 11 7 10
3LA5_A 0.91 0.84 1.00 21 933 0 0 0 0 4
3NDB_M - 0.98 0.98 0.98 43 3670 6 0 1 5 1
3NKB_B - 0.63 0.68 0.59 13 713 9 0 9 0 6
3NMU_E - 1.00 1.00 1.00 3 213 3 0 0 3 0
3NPB_A 0.86 0.84 0.89 31 2243 9 1 3 5 6
3O58_2 0.92 0.94 0.91 29 2722 10 0 3 7 2
3O58_3 0.32 0.36 0.29 8 4736 21 7 13 1 14
3OVB_D - 1.00 1.00 1.00 11 215 1 0 0 1 0
3OVS_D - 1.00 1.00 1.00 12 204 0 0 0 0 0
3P22_G - 1.00 1.00 1.00 11 301 1 0 0 1 0
3PDR_A 0.83 0.86 0.80 43 4786 13 5 6 2 7
3R4F_A - 0.81 0.82 0.82 18 884 5 2 2 1 4
3R9X_C - 1.00 1.00 1.00 8 221 2 0 0 2 0
3RKF_A 0.87 0.83 0.91 20 844 2 2 0 0 4
3SD1_A 0.68 0.69 0.69 20 1504 9 5 4 0 9
3SIU_F - 0.87 0.88 0.88 7 137 1 0 1 0 1
3SN2_B 0.95 0.92 1.00 11 143 0 0 0 0 1
3TRZ_Z - 1.00 1.00 1.00 5 87 1 0 0 1 0
3TS0_U - 1.00 1.00 1.00 6 112 1 0 0 1 0
3TS2_V - 1.00 1.00 1.00 5 103 0 0 0 0 0
3U4M_B - 0.81 0.77 0.85 17 1256 5 0 3 2 5
3UZL_B 0.90 0.88 0.93 14 1278 8 0 1 7 2
3VJR_D - 1.00 1.00 1.00 12 239 0 0 0 0 0
4A1C_2 0.21 0.25 0.19 5 4489 33 9 13 11 15
4A1C_3 0.81 0.81 0.81 30 2726 10 0 7 3 7
4A4U_A - 1.00 1.00 1.00 9 96 0 0 0 0 0
4AOB_A 0.53 0.52 0.56 15 1410 13 3 9 1 14
4ENB_A 0.85 0.73 1.00 11 461 1 0 0 1 4
4ENC_A 0.85 0.73 1.00 11 485 1 0 0 1 4

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Performance of RNAsubopt - scored lower in this pairwise comparison

1. Total counts & total scores for RNAsubopt

Total Base Pair Counts
Total TP 1542
Total TN 149912
Total FP 846
Total FP CONTRA 185
Total FP INCONS 396
Total FP COMP 265
Total FN 494
Total Scores
MCC 0.738
Average MCC ± 95% Confidence Intervals 0.770 ± 0.057
Sensitivity 0.757
Positive Predictive Value 0.726
Nr of predictions 118

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2. Individual counts for RNAsubopt [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2K5Z_A - 0.95 0.91 1.00 10 176 0 0 0 0 1
2K63_A - 0.94 0.89 1.00 8 160 0 0 0 0 1
2K66_A - 1.00 1.00 1.00 9 80 0 0 0 0 0
2KD8_A - 0.87 0.78 1.00 7 101 0 0 0 0 2
2KDQ_B 1.00 1.00 1.00 10 164 0 0 0 0 0
2KE6_A 0.88 0.89 0.89 16 449 3 0 2 1 2
2KEZ_A - 1.00 1.00 1.00 8 94 0 0 0 0 0
2KFC_A - -0.03 0.00 0.00 0 229 7 1 6 0 8
2KGP_A - 1.00 1.00 1.00 9 112 0 0 0 0 0
2KMJ_A - 1.00 1.00 1.00 11 157 0 0 0 0 0
2KPV_A - 0.96 0.92 1.00 12 201 0 0 0 0 1
2KRL_A - 0.62 0.61 0.64 14 2002 15 5 3 7 9
2KU0_A - 0.96 0.92 1.00 11 281 0 0 0 0 1
2KUR_A 0.89 0.89 0.89 17 448 2 0 2 0 2
2KUU_A 0.88 0.89 0.89 16 429 3 0 2 1 2
2KUV_A 0.89 0.89 0.89 17 420 2 0 2 0 2
2KUW_A 0.94 0.94 0.94 17 452 2 0 1 1 1
2KX8_A 0.97 0.94 1.00 15 356 0 0 0 0 1
2KXM_A - 1.00 1.00 1.00 8 141 0 0 0 0 0
2KZL_A - 1.00 1.00 1.00 13 507 1 0 0 1 0
2L1F_A 0.95 0.91 1.00 21 742 0 0 0 0 2
2L1F_B 0.96 0.92 1.00 22 769 0 0 0 0 2
2L2K_A - 1.00 1.00 1.00 17 332 0 0 0 0 0
2L3C_B - 0.96 0.93 1.00 13 226 0 0 0 0 1
2L3E_A - 1.00 1.00 1.00 12 228 1 0 0 1 0
2L3J_B 1.00 1.00 1.00 30 955 0 0 0 0 0
2L5Z_A - 1.00 1.00 1.00 9 102 0 0 0 0 0
2L94_A 1.00 1.00 1.00 18 339 1 0 0 1 0
2LA5_A - 0.77 0.71 0.83 5 269 3 0 1 2 2
2LBS_A - 1.00 1.00 1.00 14 193 0 0 0 0 0
2LC8_A -0.03 0.00 0.00 0 513 15 3 12 0 18
2LDL_A - 1.00 1.00 1.00 9 131 1 0 0 1 0
2LDT_A - 1.00 1.00 1.00 11 151 0 0 0 0 0
2LHP_A - 1.00 1.00 1.00 15 246 0 0 0 0 0
2LI4_A - 1.00 1.00 1.00 14 175 0 0 0 0 0
2LJJ_A - 1.00 1.00 1.00 7 123 3 0 0 3 0
2LK3_A - 1.00 1.00 1.00 9 91 0 0 0 0 0
2LKR_A - 0.85 0.86 0.83 25 2410 14 0 5 9 4
2LQZ_A - 1.00 1.00 1.00 8 124 2 0 0 2 0
2LWK_A - 0.95 0.91 1.00 10 197 1 0 0 1 1
2RP0_A - 0.84 0.71 1.00 5 111 0 0 0 0 2
2RPT_A - 1.00 1.00 1.00 7 65 0 0 0 0 0
2RRC_A - 1.00 1.00 1.00 7 68 0 0 0 0 0
2WRQ_Y 1.00 1.00 1.00 9 1143 13 0 0 13 0
2WW9_D - 0.09 0.10 0.11 1 732 13 2 6 5 9
2WW9_E - -0.03 0.00 0.00 0 168 5 0 4 1 5
2WW9_F - 0.52 0.63 0.50 5 102 5 1 4 0 3
2WWQ_V 1.00 1.00 1.00 19 1185 5 0 0 5 0
2XKV_B 0.64 0.73 0.57 8 1821 25 0 6 19 3
2XQD_Y 0.83 0.81 0.85 17 1109 4 0 3 1 4
2XXA_G 0.49 0.49 0.52 17 2012 17 1 15 1 18
2Y8W_B - 1.00 1.00 1.00 6 82 1 0 0 1 0
2Y9C_V - 0.79 0.83 0.75 15 886 8 0 5 3 3
2YIE_X - 1.00 1.00 1.00 7 537 4 0 0 4 0
2YIE_Z - -0.02 0.00 0.00 0 587 15 6 9 0 8
2ZY6_A - 0.66 0.78 0.58 7 264 5 3 2 0 2
2ZZM_B 0.29 0.33 0.26 5 1339 22 5 9 8 10
2ZZN_D 0.52 0.55 0.52 12 961 11 3 8 0 10
3A2K_C 0.47 0.50 0.46 11 1084 13 3 10 0 11
3A3A_A 0.97 0.93 1.00 28 1472 0 0 0 0 2
3ADB_C - 0.98 0.97 1.00 32 1787 0 0 0 0 1
3AKZ_H 0.43 0.45 0.43 9 1106 14 3 9 2 11
3AM1_B - 1.00 1.00 1.00 29 1437 0 0 0 0 0
3AMU_B 0.81 0.79 0.83 15 1139 6 0 3 3 4
3DW4_A - -0.03 0.00 0.00 0 136 6 1 3 2 6
3G4S_9 0.41 0.46 0.38 12 2704 25 7 13 5 14
3GCA_A - 0.84 0.71 1.00 5 153 0 0 0 0 2
3GX2_A 0.53 0.54 0.54 15 1421 14 4 9 1 13
3HAY_E - 1.00 1.00 1.00 14 910 4 0 0 4 0
3HJW_D - 0.97 0.94 1.00 15 594 2 0 0 2 1
3IAB_R - 1.00 1.00 1.00 12 373 0 0 0 0 0
3ID5_D - 0.54 0.60 0.50 3 223 5 1 2 2 2
3IVN_B 0.88 0.78 1.00 18 885 0 0 0 0 5
3IWN_A 0.69 0.68 0.70 19 1445 9 1 7 1 9
3IYQ_A 0.28 0.39 0.20 20 22342 96 41 37 18 31
3IZ4_A 0.56 0.60 0.53 57 25429 54 26 24 4 38
3IZF_C 0.89 0.91 0.86 32 2603 9 0 5 4 3
3J0L_h - 0.87 0.81 0.93 26 2112 4 1 1 2 6
3J0L_g - -0.01 0.00 0.00 0 173 5 1 2 2 2
3J0L_8 - 1.00 1.00 1.00 7 69 0 0 0 0 0
3J0L_a - 0.35 0.36 0.36 4 400 8 3 4 1 7
3J0L_2 - 0.28 0.31 0.28 8 2221 25 2 19 4 18
3J0L_1 - 0.83 0.77 0.91 10 473 4 0 1 3 3
3J0L_7 - -0.02 0.00 0.00 0 507 12 2 10 0 10
3J16_L 0.49 0.52 0.48 11 1136 12 3 9 0 10
3JYV_7 -0.02 0.00 0.00 0 1090 21 4 17 0 20
3JYX_3 0.77 0.80 0.75 12 2362 26 0 4 22 3
3JYX_4 0.34 0.58 0.21 7 4722 38 20 7 11 5
3KTW_C - 1.00 1.00 1.00 25 1755 8 0 0 8 0
3LA5_A 0.91 0.84 1.00 21 933 0 0 0 0 4
3NDB_M - 0.93 0.93 0.93 41 3670 9 0 3 6 3
3NKB_B - 0.66 0.68 0.65 13 715 7 0 7 0 6
3NMU_E - 1.00 1.00 1.00 3 213 5 0 0 5 0
3NPB_A 0.84 0.78 0.91 29 2246 8 0 3 5 8
3O58_2 0.87 0.90 0.85 28 2721 13 0 5 8 3
3O58_3 0.41 0.50 0.34 11 4732 35 6 15 14 11
3OVB_D - 1.00 1.00 1.00 11 215 1 0 0 1 0
3OVS_D - 1.00 1.00 1.00 12 204 0 0 0 0 0
3P22_G - 1.00 1.00 1.00 11 301 0 0 0 0 0
3PDR_A 0.90 0.90 0.90 45 4790 7 2 3 2 5
3R4F_A - 1.00 1.00 1.00 22 884 1 0 0 1 0
3R9X_C - 1.00 1.00 1.00 8 221 2 0 0 2 0
3RKF_A 0.91 0.83 1.00 20 846 0 0 0 0 4
3SD1_A 0.73 0.72 0.75 21 1505 7 4 3 0 8
3SIU_F - 1.00 1.00 1.00 8 137 0 0 0 0 0
3SN2_B 0.95 0.92 1.00 11 143 0 0 0 0 1
3TRZ_Z - 1.00 1.00 1.00 5 87 1 0 0 1 0
3TS0_U - 1.00 1.00 1.00 6 112 1 0 0 1 0
3TS2_V - 1.00 1.00 1.00 5 103 0 0 0 0 0
3U4M_B - 0.49 0.55 0.46 12 1250 14 3 11 0 10
3UZL_B 0.49 0.50 0.50 8 1277 15 0 8 7 8
3VJR_D - 1.00 1.00 1.00 12 239 0 0 0 0 0
4A1C_2 0.18 0.25 0.14 5 4481 43 13 17 13 15
4A1C_3 0.85 0.84 0.86 31 2727 8 0 5 3 6
4A4U_A - 1.00 1.00 1.00 9 96 0 0 0 0 0
4AOB_A 0.62 0.62 0.64 18 1409 11 4 6 1 11
4ENB_A 0.85 0.73 1.00 11 461 2 0 0 2 4
4ENC_A 0.36 0.33 0.42 5 484 7 0 7 0 10

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.