CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of IPknot - scored higher in this pairwise comparison

  4. Performance of RNASampler(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for IPknot & RNASampler(seed) [.zip] - may take several seconds...


Overview

Metric IPknot RNASampler(seed)
MCC 0.597 > 0.559
Average MCC ± 95% Confidence Intervals 0.572 ± 0.491 > 0.500 ± 0.651
Sensitivity 0.560 > 0.484
Positive Predictive Value 0.646 < 0.657
Total TP 51 > 44
Total TN 7364 < 7376
Total FP 36 > 31
Total FP CONTRA 9 > 4
Total FP INCONS 19 = 19
Total FP COMP 8 = 8
Total FN 40 < 47
P-value 0.0

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Performance plots


  1. Comparison of performance of IPknot and RNASampler(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for IPknot and RNASampler(seed)).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for IPknot and RNASampler(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for IPknot and RNASampler(seed)).

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Performance of IPknot - scored higher in this pairwise comparison

1. Total counts & total scores for IPknot

Total Base Pair Counts
Total TP 51
Total TN 7364
Total FP 36
Total FP CONTRA 9
Total FP INCONS 19
Total FP COMP 8
Total FN 40
Total Scores
MCC 0.597
Average MCC ± 95% Confidence Intervals 0.572 ± 0.491
Sensitivity 0.560
Positive Predictive Value 0.646
Nr of predictions 4

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2. Individual counts for IPknot [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A 0.41 0.33 0.55 6 517 5 1 4 0 12
3RKF_A 0.91 0.83 1.00 20 846 0 0 0 0 4
3SD1_A 0.74 0.69 0.80 20 1508 5 0 5 0 9
4A1C_2 0.23 0.25 0.22 5 4493 26 8 10 8 15

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Performance of RNASampler(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for RNASampler(seed)

Total Base Pair Counts
Total TP 44
Total TN 7376
Total FP 31
Total FP CONTRA 4
Total FP INCONS 19
Total FP COMP 8
Total FN 47
Total Scores
MCC 0.559
Average MCC ± 95% Confidence Intervals 0.500 ± 0.651
Sensitivity 0.484
Positive Predictive Value 0.657
Nr of predictions 4

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2. Individual counts for RNASampler(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A -0.03 0.00 0.00 0 518 10 0 10 0 18
3RKF_A 0.91 0.83 1.00 20 846 0 0 0 0 4
3SD1_A 0.72 0.55 0.94 16 1516 1 0 1 0 13
4A1C_2 0.40 0.40 0.40 8 4496 20 4 8 8 12

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.