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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of Mastr(20) - scored higher in this pairwise comparison

  4. Performance of NanoFolder - scored lower in this pairwise comparison

  5. Compile and download dataset for Mastr(20) & NanoFolder [.zip] - may take several seconds...


Overview

Metric Mastr(20) NanoFolder
MCC 0.601 > 0.389
Average MCC ± 95% Confidence Intervals 0.466 ± 0.580 > 0.405 ± 0.473
Sensitivity 0.465 < 0.475
Positive Predictive Value 0.783 > 0.331
Total TP 47 < 48
Total TN 9152 > 9067
Total FP 17 < 114
Total FP CONTRA 1 < 33
Total FP INCONS 12 < 64
Total FP COMP 4 < 17
Total FN 54 > 53
P-value 0.0

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Performance plots


  1. Comparison of performance of Mastr(20) and NanoFolder. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Mastr(20) and NanoFolder).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for Mastr(20) and NanoFolder. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Mastr(20) and NanoFolder).

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Performance of Mastr(20) - scored higher in this pairwise comparison

1. Total counts & total scores for Mastr(20)

Total Base Pair Counts
Total TP 47
Total TN 9152
Total FP 17
Total FP CONTRA 1
Total FP INCONS 12
Total FP COMP 4
Total FN 54
Total Scores
MCC 0.601
Average MCC ± 95% Confidence Intervals 0.466 ± 0.580
Sensitivity 0.465
Positive Predictive Value 0.783
Nr of predictions 4

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2. Individual counts for Mastr(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
4A1C_2 0.00 0.00 0.00 0 4516 0 0 0 0 20
4A1C_3 0.88 0.86 0.89 32 2727 7 0 4 3 5
4AOB_A 0.42 0.34 0.53 10 1418 10 1 8 1 19
4ENC_A 0.57 0.33 1.00 5 491 0 0 0 0 10

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Performance of NanoFolder - scored lower in this pairwise comparison

1. Total counts & total scores for NanoFolder

Total Base Pair Counts
Total TP 48
Total TN 9067
Total FP 114
Total FP CONTRA 33
Total FP INCONS 64
Total FP COMP 17
Total FN 53
Total Scores
MCC 0.389
Average MCC ± 95% Confidence Intervals 0.405 ± 0.473
Sensitivity 0.475
Positive Predictive Value 0.331
Nr of predictions 4

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2. Individual counts for NanoFolder [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
4A1C_2 -0.01 0.00 0.00 0 4469 61 18 29 14 20
4A1C_3 0.58 0.68 0.51 25 2714 24 9 15 0 12
4AOB_A 0.39 0.41 0.39 12 1406 20 4 15 1 17
4ENC_A 0.66 0.73 0.61 11 478 9 2 5 2 4

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.