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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of McQFold - scored higher in this pairwise comparison

  4. Performance of Multilign(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for McQFold & Multilign(seed) [.zip] - may take several seconds...


Overview

Metric McQFold Multilign(seed)
MCC 0.761 > 0.683
Average MCC ± 95% Confidence Intervals 0.774 ± 0.253 > 0.649 ± 0.495
Sensitivity 0.737 > 0.636
Positive Predictive Value 0.798 > 0.750
Total TP 87 > 75
Total TN 4612 < 4621
Total FP 24 < 26
Total FP CONTRA 5 < 7
Total FP INCONS 17 < 18
Total FP COMP 2 > 1
Total FN 31 < 43
P-value 0.0

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Performance plots


  1. Comparison of performance of McQFold and Multilign(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for McQFold and Multilign(seed)).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for McQFold and Multilign(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for McQFold and Multilign(seed)).

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Performance of McQFold - scored higher in this pairwise comparison

1. Total counts & total scores for McQFold

Total Base Pair Counts
Total TP 87
Total TN 4612
Total FP 24
Total FP CONTRA 5
Total FP INCONS 17
Total FP COMP 2
Total FN 31
Total Scores
MCC 0.761
Average MCC ± 95% Confidence Intervals 0.774 ± 0.253
Sensitivity 0.737
Positive Predictive Value 0.798
Nr of predictions 5

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2. Individual counts for McQFold [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2L94_A 1.00 1.00 1.00 18 339 1 0 0 1 0
2LC8_A 0.64 0.61 0.69 11 512 5 1 4 0 7
3RKF_A 0.91 0.83 1.00 20 846 0 0 0 0 4
3SD1_A 0.82 0.83 0.83 24 1504 5 1 4 0 5
4AOB_A 0.50 0.48 0.54 14 1411 13 3 9 1 15

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Performance of Multilign(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for Multilign(seed)

Total Base Pair Counts
Total TP 75
Total TN 4621
Total FP 26
Total FP CONTRA 7
Total FP INCONS 18
Total FP COMP 1
Total FN 43
Total Scores
MCC 0.683
Average MCC ± 95% Confidence Intervals 0.649 ± 0.495
Sensitivity 0.636
Positive Predictive Value 0.750
Nr of predictions 5

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2. Individual counts for Multilign(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2L94_A 0.97 0.94 1.00 17 340 0 0 0 0 1
2LC8_A -0.03 0.00 0.00 0 516 12 2 10 0 18
3RKF_A 0.91 0.83 1.00 20 846 0 0 0 0 4
3SD1_A 0.66 0.66 0.68 19 1505 9 4 5 0 10
4AOB_A 0.73 0.66 0.83 19 1414 5 1 3 1 10

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.