CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of McQFold - scored higher in this pairwise comparison

  4. Performance of Vsfold4 - scored lower in this pairwise comparison

  5. Compile and download dataset for McQFold & Vsfold4 [.zip] - may take several seconds...


Overview

Metric McQFold Vsfold4
MCC 0.718 > 0.647
Average MCC ± 95% Confidence Intervals 0.761 ± 0.055 > 0.699 ± 0.061
Sensitivity 0.719 > 0.637
Positive Predictive Value 0.725 > 0.667
Total TP 1453 > 1289
Total TN 149842 < 149913
Total FP 747 < 814
Total FP CONTRA 199 > 181
Total FP INCONS 352 < 463
Total FP COMP 196 > 170
Total FN 569 < 733
P-value 3.56938820447e-08

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Performance plots


  1. Comparison of performance of McQFold and Vsfold4. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for McQFold and Vsfold4).

  2. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for McQFold and Vsfold4).

  3. Comparison of average Matthews Correlation Coefficients (MCCs) for McQFold and Vsfold4. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for McQFold and Vsfold4).

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Performance of McQFold - scored higher in this pairwise comparison

1. Total counts & total scores for McQFold

Total Base Pair Counts
Total TP 1453
Total TN 149842
Total FP 747
Total FP CONTRA 199
Total FP INCONS 352
Total FP COMP 196
Total FN 569
Total Scores
MCC 0.718
Average MCC ± 95% Confidence Intervals 0.761 ± 0.055
Sensitivity 0.719
Positive Predictive Value 0.725
Nr of predictions 117

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2. Individual counts for McQFold [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2K5Z_A - 0.59 0.36 1.00 4 182 0 0 0 0 7
2K63_A - 1.00 1.00 1.00 9 159 0 0 0 0 0
2K66_A - 1.00 1.00 1.00 9 80 0 0 0 0 0
2KD8_A - 1.00 1.00 1.00 9 99 1 0 0 1 0
2KDQ_B 1.00 1.00 1.00 10 164 0 0 0 0 0
2KE6_A 0.91 0.83 1.00 15 452 1 0 0 1 3
2KEZ_A - 1.00 1.00 1.00 8 94 0 0 0 0 0
2KFC_A - 0.79 0.63 1.00 5 231 0 0 0 0 3
2KGP_A - 0.81 0.67 1.00 6 115 1 0 0 1 3
2KMJ_A - 1.00 1.00 1.00 11 157 1 0 0 1 0
2KPV_A - 0.96 0.92 1.00 12 201 0 0 0 0 1
2KRL_A - 0.75 0.83 0.68 19 1996 15 7 2 6 4
2KU0_A - 0.86 0.75 1.00 9 283 0 0 0 0 3
2KUR_A 0.91 0.84 1.00 16 451 0 0 0 0 3
2KUU_A 0.91 0.83 1.00 15 432 1 0 0 1 3
2KUV_A 0.91 0.84 1.00 16 423 0 0 0 0 3
2KUW_A 0.94 0.89 1.00 16 454 0 0 0 0 2
2KX8_A 0.93 0.94 0.94 15 355 1 0 1 0 1
2KXM_A - 0.78 0.63 1.00 5 144 0 0 0 0 3
2KZL_A - 1.00 1.00 1.00 13 507 2 0 0 2 0
2L1F_B 1.00 1.00 1.00 24 767 0 0 0 0 0
2L1F_A 1.00 1.00 1.00 23 740 0 0 0 0 0
2L2K_A - 1.00 1.00 1.00 17 332 1 0 0 1 0
2L3C_B - 1.00 1.00 1.00 14 225 1 0 0 1 0
2L3E_A - 1.00 1.00 1.00 12 228 2 0 0 2 0
2L3J_B 0.95 0.90 1.00 27 958 0 0 0 0 3
2L5Z_A - 1.00 1.00 1.00 9 102 0 0 0 0 0
2L94_A 1.00 1.00 1.00 18 339 1 0 0 1 0
2LA5_A - 0.77 0.71 0.83 5 269 1 0 1 0 2
2LBS_A - 1.00 1.00 1.00 14 193 1 0 0 1 0
2LC8_A 0.64 0.61 0.69 11 512 5 1 4 0 7
2LDL_A - 0.81 0.67 1.00 6 134 0 0 0 0 3
2LDT_A - 0.79 0.64 1.00 7 155 0 0 0 0 4
2LHP_A - 1.00 1.00 1.00 15 246 1 0 0 1 0
2LJJ_A - 1.00 1.00 1.00 7 123 3 0 0 3 0
2LK3_A - 1.00 1.00 1.00 9 91 0 0 0 0 0
2LKR_A - 0.55 0.55 0.55 16 2411 15 5 8 2 13
2LQZ_A - 1.00 1.00 1.00 8 124 3 0 0 3 0
2LWK_A - 0.95 0.91 1.00 10 197 2 0 0 2 1
2RP0_A - 0.84 0.71 1.00 5 111 0 0 0 0 2
2RPT_A - 1.00 1.00 1.00 7 65 0 0 0 0 0
2RRC_A - 0.83 0.71 1.00 5 70 0 0 0 0 2
2WRQ_Y 1.00 1.00 1.00 9 1143 14 0 0 14 0
2WW9_F - 0.86 0.75 1.00 6 106 1 0 0 1 2
2WW9_D - 0.44 0.40 0.50 4 733 9 4 0 5 6
2WW9_E - -0.03 0.00 0.00 0 168 5 0 4 1 5
2WWQ_V 0.00 0.00 0.00 0 1204 0 0 0 0 19
2XKV_B 0.33 0.36 0.31 4 1822 27 2 7 18 7
2XQD_Y 0.98 0.95 1.00 20 1109 1 0 0 1 1
2XXA_G 0.27 0.26 0.30 9 2015 22 0 21 1 26
2Y8W_B - 1.00 1.00 1.00 6 82 2 0 0 2 0
2Y9C_V - 0.72 0.72 0.72 13 888 8 0 5 3 5
2YIE_X - 0.53 0.57 0.50 4 536 6 1 3 2 3
2YIE_Z - 0.53 0.63 0.45 5 591 6 4 2 0 3
2ZY6_A - 0.66 0.78 0.58 7 264 5 3 2 0 2
2ZZM_B 0.18 0.20 0.19 3 1342 22 4 9 9 12
2ZZN_D 0.93 0.95 0.91 21 961 2 2 0 0 1
3A2K_C 0.98 0.95 1.00 21 1087 0 0 0 0 1
3A3A_A 0.97 0.93 1.00 28 1472 0 0 0 0 2
3ADB_C - 0.98 0.97 1.00 32 1787 1 0 0 1 1
3AKZ_H 0.78 0.80 0.76 16 1106 7 2 3 2 4
3AM1_B - 1.00 1.00 1.00 29 1437 1 0 0 1 0
3AMU_B 0.86 0.79 0.94 15 1141 4 0 1 3 4
3DW4_A - -0.03 0.00 0.00 0 137 3 0 3 0 6
3G4S_9 0.39 0.42 0.37 11 2706 22 6 13 3 15
3GCA_A - 0.84 0.71 1.00 5 153 0 0 0 0 2
3GX2_A 0.56 0.57 0.57 16 1421 13 4 8 1 12
3HAY_E - 1.00 1.00 1.00 14 910 4 0 0 4 0
3HJW_D - 0.94 0.94 0.94 15 593 3 0 1 2 1
3IAB_R - 1.00 1.00 1.00 12 373 0 0 0 0 0
3ID5_D - 0.66 0.60 0.75 3 225 6 0 1 5 2
3IVN_B 0.91 0.83 1.00 19 884 0 0 0 0 4
3IWN_A 0.21 0.21 0.24 6 1447 19 2 17 0 22
3IYQ_A 0.22 0.31 0.15 16 22335 100 45 44 11 35
3IZ4_A 0.46 0.46 0.47 44 25442 56 14 36 6 51
3IZF_C 0.85 0.83 0.88 29 2607 7 0 4 3 6
3J0L_h - 0.75 0.66 0.88 21 2116 3 0 3 0 11
3J0L_1 - 0.73 0.62 0.89 8 475 4 0 1 3 5
3J0L_2 - 0.29 0.31 0.30 8 2223 21 1 18 2 18
3J0L_g - -0.01 0.00 0.00 0 174 4 0 2 2 2
3J0L_8 - 1.00 1.00 1.00 7 69 0 0 0 0 0
3J0L_a - 0.21 0.18 0.29 2 404 6 3 2 1 9
3J0L_7 - -0.02 0.00 0.00 0 509 10 2 8 0 10
3J16_L 0.90 0.81 1.00 17 1142 0 0 0 0 4
3JYV_7 -0.02 0.00 0.00 0 1091 20 4 16 0 20
3JYX_4 0.35 0.58 0.22 7 4724 33 17 8 8 5
3JYX_3 0.28 0.40 0.20 6 2348 24 17 7 0 9
3KTW_C - 0.52 0.52 0.54 13 1756 17 2 9 6 12
3LA5_A 0.91 0.84 1.00 21 933 0 0 0 0 4
3NDB_M - 0.97 0.95 0.98 42 3671 5 0 1 4 2
3NKB_B - 0.42 0.42 0.44 8 717 10 2 8 0 11
3NMU_E - 0.57 0.33 1.00 1 215 3 0 0 3 2
3NPB_A 0.90 0.81 1.00 30 2248 5 0 0 5 7
3O58_3 0.30 0.36 0.25 8 4732 27 15 9 3 14
3O58_2 0.93 0.87 1.00 27 2727 2 0 0 2 4
3OVB_D - 1.00 1.00 1.00 11 215 1 0 0 1 0
3OVS_D - 1.00 1.00 1.00 12 204 0 0 0 0 0
3P22_G - 1.00 1.00 1.00 11 301 0 0 0 0 0
3PDR_A 0.83 0.80 0.87 40 4794 9 2 4 3 10
3R4F_A - 1.00 1.00 1.00 22 884 2 0 0 2 0
3R9X_C - 1.00 1.00 1.00 8 221 2 0 0 2 0
3RKF_A 0.91 0.83 1.00 20 846 0 0 0 0 4
3SD1_A 0.82 0.83 0.83 24 1504 5 1 4 0 5
3SIU_F - 0.86 0.75 1.00 6 139 0 0 0 0 2
3SN2_B 0.95 0.92 1.00 11 143 0 0 0 0 1
3TRZ_Z - 1.00 1.00 1.00 5 87 2 0 0 2 0
3TS0_U - 1.00 1.00 1.00 6 112 1 0 0 1 0
3TS2_V - 1.00 1.00 1.00 5 103 0 0 0 0 0
3U4M_B - 0.95 0.91 1.00 20 1256 2 0 0 2 2
3UZL_B 0.62 0.75 0.52 12 1270 17 8 3 6 4
3VJR_D - 1.00 1.00 1.00 12 239 0 0 0 0 0
4A1C_2 0.19 0.25 0.16 5 4484 33 11 16 6 15
4A1C_3 0.28 0.30 0.28 11 2724 30 4 24 2 26
4A4U_A - 1.00 1.00 1.00 9 96 0 0 0 0 0
4AOB_A 0.50 0.48 0.54 14 1411 13 3 9 1 15
4ENB_A 1.00 1.00 1.00 15 457 0 0 0 0 0
4ENC_A 0.97 1.00 0.94 15 480 1 1 0 0 0

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Performance of Vsfold4 - scored lower in this pairwise comparison

1. Total counts & total scores for Vsfold4

Total Base Pair Counts
Total TP 1289
Total TN 149913
Total FP 814
Total FP CONTRA 181
Total FP INCONS 463
Total FP COMP 170
Total FN 733
Total Scores
MCC 0.647
Average MCC ± 95% Confidence Intervals 0.699 ± 0.061
Sensitivity 0.637
Positive Predictive Value 0.667
Nr of predictions 117

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2. Individual counts for Vsfold4 [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2K5Z_A - 0.35 0.36 0.40 4 176 6 0 6 0 7
2K63_A - 1.00 1.00 1.00 9 159 0 0 0 0 0
2K66_A - 1.00 1.00 1.00 9 80 0 0 0 0 0
2KD8_A - 1.00 1.00 1.00 9 99 0 0 0 0 0
2KDQ_B 1.00 1.00 1.00 10 164 0 0 0 0 0
2KE6_A 1.00 1.00 1.00 18 449 1 0 0 1 0
2KEZ_A - 0.78 0.63 1.00 5 97 0 0 0 0 3
2KFC_A - 0.79 0.63 1.00 5 231 0 0 0 0 3
2KGP_A - -0.05 0.00 0.00 0 117 4 0 4 0 9
2KMJ_A - 1.00 1.00 1.00 11 157 0 0 0 0 0
2KPV_A - 0.96 0.92 1.00 12 201 0 0 0 0 1
2KRL_A - 0.84 0.83 0.86 19 2002 9 2 1 6 4
2KU0_A - -0.04 0.00 0.00 0 283 9 2 7 0 12
2KUR_A 1.00 1.00 1.00 19 448 0 0 0 0 0
2KUU_A 1.00 1.00 1.00 18 429 1 0 0 1 0
2KUV_A 1.00 1.00 1.00 19 420 0 0 0 0 0
2KUW_A 1.00 1.00 1.00 18 452 1 0 0 1 0
2KX8_A 1.00 1.00 1.00 16 355 0 0 0 0 0
2KXM_A - 0.78 0.63 1.00 5 144 0 0 0 0 3
2KZL_A - 1.00 1.00 1.00 13 507 1 0 0 1 0
2L1F_B 0.69 0.58 0.82 14 774 3 0 3 0 10
2L1F_A 0.67 0.57 0.81 13 747 3 0 3 0 10
2L2K_A - 0.94 0.88 1.00 15 334 0 0 0 0 2
2L3C_B - 1.00 1.00 1.00 14 225 0 0 0 0 0
2L3E_A - 1.00 1.00 1.00 12 228 1 0 0 1 0
2L3J_B 0.93 0.87 1.00 26 959 0 0 0 0 4
2L5Z_A - 0.68 0.67 0.75 6 103 2 0 2 0 3
2L94_A 0.94 0.89 1.00 16 341 1 0 0 1 2
2LA5_A - 0.77 0.71 0.83 5 269 1 0 1 0 2
2LBS_A - 1.00 1.00 1.00 14 193 0 0 0 0 0
2LC8_A -0.03 0.00 0.00 0 515 13 0 13 0 18
2LDL_A - 0.94 0.89 1.00 8 132 1 0 0 1 1
2LDT_A - 1.00 1.00 1.00 11 151 0 0 0 0 0
2LHP_A - 1.00 1.00 1.00 15 246 0 0 0 0 0
2LJJ_A - 1.00 1.00 1.00 7 123 3 0 0 3 0
2LK3_A - 1.00 1.00 1.00 9 91 0 0 0 0 0
2LKR_A - 0.35 0.38 0.34 11 2408 21 7 14 0 18
2LQZ_A - 1.00 1.00 1.00 8 124 2 0 0 2 0
2LWK_A - 0.95 0.91 1.00 10 197 1 0 0 1 1
2RP0_A - 0.84 0.71 1.00 5 111 0 0 0 0 2
2RPT_A - -0.07 0.00 0.00 0 68 4 0 4 0 7
2RRC_A - 0.83 0.71 1.00 5 70 0 0 0 0 2
2WRQ_Y 0.94 0.89 1.00 8 1144 13 0 0 13 1
2WW9_F - 0.68 0.75 0.67 6 103 4 1 2 1 2
2WW9_D - 0.12 0.10 0.17 1 735 8 1 4 3 9
2WW9_E - -0.03 0.00 0.00 0 168 5 0 4 1 5
2WWQ_V 0.78 0.74 0.82 14 1187 4 1 2 1 5
2XKV_B -0.01 0.00 0.00 0 1808 27 13 14 0 11
2XQD_Y 0.95 0.90 1.00 19 1110 1 0 0 1 2
2XXA_G -0.02 0.00 0.00 0 2016 29 1 28 0 35
2Y8W_B - 1.00 1.00 1.00 6 82 1 0 0 1 0
2Y9C_V - 0.75 0.67 0.86 12 892 4 0 2 2 6
2YIE_X - 0.53 0.57 0.50 4 536 6 1 3 2 3
2YIE_Z - -0.02 0.00 0.00 0 591 11 5 6 0 8
2ZY6_A - 0.66 0.78 0.58 7 264 5 3 2 0 2
2ZZM_B 0.18 0.20 0.19 3 1342 22 4 9 9 12
2ZZN_D 0.95 0.95 0.95 21 962 1 1 0 0 1
3A2K_C 0.95 0.91 1.00 20 1088 0 0 0 0 2
3A3A_A 0.95 0.90 1.00 27 1473 0 0 0 0 3
3ADB_C - 0.95 0.91 1.00 30 1789 0 0 0 0 3
3AKZ_H 0.77 0.75 0.79 15 1108 6 2 2 2 5
3AM1_B - 0.93 0.86 1.00 25 1441 0 0 0 0 4
3AMU_B 0.73 0.74 0.74 14 1138 8 0 5 3 5
3DW4_A - 0.91 0.83 1.00 5 135 0 0 0 0 1
3G4S_9 0.41 0.46 0.38 12 2704 21 10 10 1 14
3GCA_A - 0.84 0.71 1.00 5 153 0 0 0 0 2
3GX2_A 0.60 0.57 0.64 16 1424 10 0 9 1 12
3HAY_E - 1.00 1.00 1.00 14 910 4 0 0 4 0
3HJW_D - 0.53 0.56 0.53 9 592 8 2 6 0 7
3IAB_R - 1.00 1.00 1.00 12 373 0 0 0 0 0
3ID5_D - 0.59 0.60 0.60 3 224 4 0 2 2 2
3IVN_B 0.91 0.83 1.00 19 884 0 0 0 0 4
3IWN_A 0.28 0.25 0.35 7 1452 13 2 11 0 21
3IYQ_A 0.27 0.35 0.21 18 22353 80 40 29 11 33
3IZ4_A 0.39 0.39 0.39 37 25441 63 15 43 5 58
3IZF_C 0.85 0.83 0.88 29 2607 6 0 4 2 6
3J0L_h - 0.44 0.38 0.52 12 2117 11 2 9 0 20
3J0L_1 - 0.26 0.23 0.33 3 475 7 2 4 1 10
3J0L_2 - 0.47 0.46 0.50 12 2226 18 1 11 6 14
3J0L_g - -0.01 0.00 0.00 0 174 4 0 2 2 2
3J0L_8 - 0.74 0.57 1.00 4 72 0 0 0 0 3
3J0L_a - 0.39 0.36 0.44 4 402 6 4 1 1 7
3J0L_7 - 0.69 0.70 0.70 7 509 4 1 2 1 3
3J16_L 0.98 0.95 1.00 20 1139 0 0 0 0 1
3JYV_7 -0.02 0.00 0.00 0 1092 19 4 15 0 20
3JYX_4 0.19 0.25 0.15 3 4736 33 9 8 16 9
3JYX_3 0.64 0.67 0.63 10 2362 16 5 1 10 5
3KTW_C - 0.43 0.40 0.48 10 1759 15 2 9 4 15
3LA5_A 0.91 0.84 1.00 21 933 0 0 0 0 4
3NDB_M - 0.33 0.32 0.35 14 3674 26 2 24 0 30
3NKB_B - 0.69 0.74 0.67 14 714 7 0 7 0 5
3NMU_E - 0.57 0.33 1.00 1 215 3 0 0 3 2
3NPB_A 0.66 0.59 0.73 22 2248 10 0 8 2 15
3O58_3 0.12 0.14 0.11 3 4737 35 8 16 11 19
3O58_2 0.53 0.52 0.55 16 2725 16 3 10 3 15
3OVB_D - 1.00 1.00 1.00 11 215 1 0 0 1 0
3OVS_D - 1.00 1.00 1.00 12 204 0 0 0 0 0
3P22_G - 1.00 1.00 1.00 11 301 0 0 0 0 0
3PDR_A 0.69 0.64 0.74 32 4797 13 3 8 2 18
3R4F_A - 0.98 0.95 1.00 21 885 1 0 0 1 1
3R9X_C - 1.00 1.00 1.00 8 221 2 0 0 2 0
3RKF_A 0.91 0.83 1.00 20 846 0 0 0 0 4
3SD1_A 0.23 0.24 0.24 7 1504 22 5 17 0 22
3SIU_F - 0.86 0.75 1.00 6 139 0 0 0 0 2
3SN2_B 0.95 0.92 1.00 11 143 0 0 0 0 1
3TRZ_Z - 1.00 1.00 1.00 5 87 1 0 0 1 0
3TS0_U - 1.00 1.00 1.00 6 112 1 0 0 1 0
3TS2_V - 1.00 1.00 1.00 5 103 0 0 0 0 0
3U4M_B - 0.49 0.55 0.46 12 1250 14 3 11 0 10
3UZL_B 0.66 0.69 0.65 11 1276 10 3 3 4 5
3VJR_D - 1.00 1.00 1.00 12 239 0 0 0 0 0
4A1C_2 0.36 0.40 0.33 8 4492 28 4 12 12 12
4A1C_3 0.29 0.30 0.31 11 2727 26 4 21 1 26
4A4U_A - 1.00 1.00 1.00 9 96 0 0 0 0 0
4AOB_A 0.50 0.48 0.54 14 1411 13 3 9 1 15
4ENB_A 0.85 0.73 1.00 11 461 0 0 0 0 4
4ENC_A 0.77 0.60 1.00 9 487 0 0 0 0 6

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.