CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of McQFold - scored higher in this pairwise comparison

  4. Performance of Vsfold5 - scored lower in this pairwise comparison

  5. Compile and download dataset for McQFold & Vsfold5 [.zip] - may take several seconds...


Overview

Metric McQFold Vsfold5
MCC 0.717 > 0.610
Average MCC ± 95% Confidence Intervals 0.759 ± 0.056 > 0.677 ± 0.065
Sensitivity 0.717 > 0.610
Positive Predictive Value 0.724 > 0.619
Total TP 1445 > 1229
Total TN 149718 < 149729
Total FP 744 < 920
Total FP CONTRA 199 < 212
Total FP INCONS 352 < 544
Total FP COMP 193 > 164
Total FN 569 < 785
P-value 3.56938820447e-08

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Performance plots


  1. Comparison of performance of McQFold and Vsfold5. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for McQFold and Vsfold5).

  2. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for McQFold and Vsfold5).

  3. Comparison of average Matthews Correlation Coefficients (MCCs) for McQFold and Vsfold5. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for McQFold and Vsfold5).

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Performance of McQFold - scored higher in this pairwise comparison

1. Total counts & total scores for McQFold

Total Base Pair Counts
Total TP 1445
Total TN 149718
Total FP 744
Total FP CONTRA 199
Total FP INCONS 352
Total FP COMP 193
Total FN 569
Total Scores
MCC 0.717
Average MCC ± 95% Confidence Intervals 0.759 ± 0.056
Sensitivity 0.717
Positive Predictive Value 0.724
Nr of predictions 116

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2. Individual counts for McQFold [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2K5Z_A - 0.59 0.36 1.00 4 182 0 0 0 0 7
2K63_A - 1.00 1.00 1.00 9 159 0 0 0 0 0
2K66_A - 1.00 1.00 1.00 9 80 0 0 0 0 0
2KD8_A - 1.00 1.00 1.00 9 99 1 0 0 1 0
2KDQ_B 1.00 1.00 1.00 10 164 0 0 0 0 0
2KE6_A 0.91 0.83 1.00 15 452 1 0 0 1 3
2KEZ_A - 1.00 1.00 1.00 8 94 0 0 0 0 0
2KFC_A - 0.79 0.63 1.00 5 231 0 0 0 0 3
2KGP_A - 0.81 0.67 1.00 6 115 1 0 0 1 3
2KMJ_A - 1.00 1.00 1.00 11 157 1 0 0 1 0
2KPV_A - 0.96 0.92 1.00 12 201 0 0 0 0 1
2KRL_A - 0.75 0.83 0.68 19 1996 15 7 2 6 4
2KU0_A - 0.86 0.75 1.00 9 283 0 0 0 0 3
2KUR_A 0.91 0.84 1.00 16 451 0 0 0 0 3
2KUU_A 0.91 0.83 1.00 15 432 1 0 0 1 3
2KUV_A 0.91 0.84 1.00 16 423 0 0 0 0 3
2KUW_A 0.94 0.89 1.00 16 454 0 0 0 0 2
2KX8_A 0.93 0.94 0.94 15 355 1 0 1 0 1
2KXM_A - 0.78 0.63 1.00 5 144 0 0 0 0 3
2KZL_A - 1.00 1.00 1.00 13 507 2 0 0 2 0
2L1F_A 1.00 1.00 1.00 23 740 0 0 0 0 0
2L1F_B 1.00 1.00 1.00 24 767 0 0 0 0 0
2L2K_A - 1.00 1.00 1.00 17 332 1 0 0 1 0
2L3C_B - 1.00 1.00 1.00 14 225 1 0 0 1 0
2L3E_A - 1.00 1.00 1.00 12 228 2 0 0 2 0
2L3J_B 0.95 0.90 1.00 27 958 0 0 0 0 3
2L5Z_A - 1.00 1.00 1.00 9 102 0 0 0 0 0
2L94_A 1.00 1.00 1.00 18 339 1 0 0 1 0
2LA5_A - 0.77 0.71 0.83 5 269 1 0 1 0 2
2LBS_A - 1.00 1.00 1.00 14 193 1 0 0 1 0
2LC8_A 0.64 0.61 0.69 11 512 5 1 4 0 7
2LDL_A - 0.81 0.67 1.00 6 134 0 0 0 0 3
2LDT_A - 0.79 0.64 1.00 7 155 0 0 0 0 4
2LHP_A - 1.00 1.00 1.00 15 246 1 0 0 1 0
2LJJ_A - 1.00 1.00 1.00 7 123 3 0 0 3 0
2LK3_A - 1.00 1.00 1.00 9 91 0 0 0 0 0
2LKR_A - 0.55 0.55 0.55 16 2411 15 5 8 2 13
2LWK_A - 0.95 0.91 1.00 10 197 2 0 0 2 1
2RP0_A - 0.84 0.71 1.00 5 111 0 0 0 0 2
2RPT_A - 1.00 1.00 1.00 7 65 0 0 0 0 0
2RRC_A - 0.83 0.71 1.00 5 70 0 0 0 0 2
2WRQ_Y 1.00 1.00 1.00 9 1143 14 0 0 14 0
2WW9_F - 0.86 0.75 1.00 6 106 1 0 0 1 2
2WW9_E - -0.03 0.00 0.00 0 168 5 0 4 1 5
2WW9_D - 0.44 0.40 0.50 4 733 9 4 0 5 6
2WWQ_V 0.00 0.00 0.00 0 1204 0 0 0 0 19
2XKV_B 0.33 0.36 0.31 4 1822 27 2 7 18 7
2XQD_Y 0.98 0.95 1.00 20 1109 1 0 0 1 1
2XXA_G 0.27 0.26 0.30 9 2015 22 0 21 1 26
2Y8W_B - 1.00 1.00 1.00 6 82 2 0 0 2 0
2Y9C_V - 0.72 0.72 0.72 13 888 8 0 5 3 5
2YIE_Z - 0.53 0.63 0.45 5 591 6 4 2 0 3
2YIE_X - 0.53 0.57 0.50 4 536 6 1 3 2 3
2ZY6_A - 0.66 0.78 0.58 7 264 5 3 2 0 2
2ZZM_B 0.18 0.20 0.19 3 1342 22 4 9 9 12
2ZZN_D 0.93 0.95 0.91 21 961 2 2 0 0 1
3A2K_C 0.98 0.95 1.00 21 1087 0 0 0 0 1
3A3A_A 0.97 0.93 1.00 28 1472 0 0 0 0 2
3ADB_C - 0.98 0.97 1.00 32 1787 1 0 0 1 1
3AKZ_H 0.78 0.80 0.76 16 1106 7 2 3 2 4
3AM1_B - 1.00 1.00 1.00 29 1437 1 0 0 1 0
3AMU_B 0.86 0.79 0.94 15 1141 4 0 1 3 4
3DW4_A - -0.03 0.00 0.00 0 137 3 0 3 0 6
3G4S_9 0.39 0.42 0.37 11 2706 22 6 13 3 15
3GCA_A - 0.84 0.71 1.00 5 153 0 0 0 0 2
3GX2_A 0.56 0.57 0.57 16 1421 13 4 8 1 12
3HAY_E - 1.00 1.00 1.00 14 910 4 0 0 4 0
3HJW_D - 0.94 0.94 0.94 15 593 3 0 1 2 1
3IAB_R - 1.00 1.00 1.00 12 373 0 0 0 0 0
3ID5_D - 0.66 0.60 0.75 3 225 6 0 1 5 2
3IVN_B 0.91 0.83 1.00 19 884 0 0 0 0 4
3IWN_A 0.21 0.21 0.24 6 1447 19 2 17 0 22
3IYQ_A 0.22 0.31 0.15 16 22335 100 45 44 11 35
3IZ4_A 0.46 0.46 0.47 44 25442 56 14 36 6 51
3IZF_C 0.85 0.83 0.88 29 2607 7 0 4 3 6
3J0L_7 - -0.02 0.00 0.00 0 509 10 2 8 0 10
3J0L_h - 0.75 0.66 0.88 21 2116 3 0 3 0 11
3J0L_1 - 0.73 0.62 0.89 8 475 4 0 1 3 5
3J0L_a - 0.21 0.18 0.29 2 404 6 3 2 1 9
3J0L_g - -0.01 0.00 0.00 0 174 4 0 2 2 2
3J0L_8 - 1.00 1.00 1.00 7 69 0 0 0 0 0
3J0L_2 - 0.29 0.31 0.30 8 2223 21 1 18 2 18
3J16_L 0.90 0.81 1.00 17 1142 0 0 0 0 4
3JYV_7 -0.02 0.00 0.00 0 1091 20 4 16 0 20
3JYX_3 0.28 0.40 0.20 6 2348 24 17 7 0 9
3JYX_4 0.35 0.58 0.22 7 4724 33 17 8 8 5
3KTW_C - 0.52 0.52 0.54 13 1756 17 2 9 6 12
3LA5_A 0.91 0.84 1.00 21 933 0 0 0 0 4
3NDB_M - 0.97 0.95 0.98 42 3671 5 0 1 4 2
3NKB_B - 0.42 0.42 0.44 8 717 10 2 8 0 11
3NMU_E - 0.57 0.33 1.00 1 215 3 0 0 3 2
3NPB_A 0.90 0.81 1.00 30 2248 5 0 0 5 7
3O58_3 0.30 0.36 0.25 8 4732 27 15 9 3 14
3O58_2 0.93 0.87 1.00 27 2727 2 0 0 2 4
3OVB_D - 1.00 1.00 1.00 11 215 1 0 0 1 0
3OVS_D - 1.00 1.00 1.00 12 204 0 0 0 0 0
3P22_G - 1.00 1.00 1.00 11 301 0 0 0 0 0
3PDR_A 0.83 0.80 0.87 40 4794 9 2 4 3 10
3R4F_A - 1.00 1.00 1.00 22 884 2 0 0 2 0
3R9X_C - 1.00 1.00 1.00 8 221 2 0 0 2 0
3RKF_A 0.91 0.83 1.00 20 846 0 0 0 0 4
3SD1_A 0.82 0.83 0.83 24 1504 5 1 4 0 5
3SIU_F - 0.86 0.75 1.00 6 139 0 0 0 0 2
3SN2_B 0.95 0.92 1.00 11 143 0 0 0 0 1
3TRZ_Z - 1.00 1.00 1.00 5 87 2 0 0 2 0
3TS0_U - 1.00 1.00 1.00 6 112 1 0 0 1 0
3TS2_V - 1.00 1.00 1.00 5 103 0 0 0 0 0
3U4M_B - 0.95 0.91 1.00 20 1256 2 0 0 2 2
3UZL_B 0.62 0.75 0.52 12 1270 17 8 3 6 4
3VJR_D - 1.00 1.00 1.00 12 239 0 0 0 0 0
4A1C_3 0.28 0.30 0.28 11 2724 30 4 24 2 26
4A1C_2 0.19 0.25 0.16 5 4484 33 11 16 6 15
4A4U_A - 1.00 1.00 1.00 9 96 0 0 0 0 0
4AOB_A 0.50 0.48 0.54 14 1411 13 3 9 1 15
4ENB_A 1.00 1.00 1.00 15 457 0 0 0 0 0
4ENC_A 0.97 1.00 0.94 15 480 1 1 0 0 0

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Performance of Vsfold5 - scored lower in this pairwise comparison

1. Total counts & total scores for Vsfold5

Total Base Pair Counts
Total TP 1229
Total TN 149729
Total FP 920
Total FP CONTRA 212
Total FP INCONS 544
Total FP COMP 164
Total FN 785
Total Scores
MCC 0.610
Average MCC ± 95% Confidence Intervals 0.677 ± 0.065
Sensitivity 0.610
Positive Predictive Value 0.619
Nr of predictions 116

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2. Individual counts for Vsfold5 [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2K5Z_A - 1.00 1.00 1.00 11 175 0 0 0 0 0
2K63_A - 1.00 1.00 1.00 9 159 0 0 0 0 0
2K66_A - 1.00 1.00 1.00 9 80 0 0 0 0 0
2KD8_A - 1.00 1.00 1.00 9 99 0 0 0 0 0
2KDQ_B 0.95 0.90 1.00 9 165 0 0 0 0 1
2KE6_A 1.00 1.00 1.00 18 449 1 0 0 1 0
2KEZ_A - 0.78 0.63 1.00 5 97 0 0 0 0 3
2KFC_A - 0.77 0.88 0.70 7 226 3 2 1 0 1
2KGP_A - 0.81 0.67 1.00 6 115 1 0 0 1 3
2KMJ_A - 0.95 0.91 1.00 10 158 0 0 0 0 1
2KPV_A - 0.96 0.92 1.00 12 201 0 0 0 0 1
2KRL_A - 0.71 0.78 0.64 18 1996 13 8 2 3 5
2KU0_A - -0.04 0.00 0.00 0 281 11 0 11 0 12
2KUR_A 1.00 1.00 1.00 19 448 0 0 0 0 0
2KUU_A 1.00 1.00 1.00 18 429 1 0 0 1 0
2KUV_A 1.00 1.00 1.00 19 420 0 0 0 0 0
2KUW_A 1.00 1.00 1.00 18 452 1 0 0 1 0
2KX8_A 0.97 0.94 1.00 15 356 0 0 0 0 1
2KXM_A - 0.78 0.63 1.00 5 144 0 0 0 0 3
2KZL_A - 1.00 1.00 1.00 13 507 1 0 0 1 0
2L1F_A 0.70 0.61 0.82 14 746 3 0 3 0 9
2L1F_B 0.71 0.63 0.83 15 773 3 0 3 0 9
2L2K_A - 0.94 0.88 1.00 15 334 0 0 0 0 2
2L3C_B - 1.00 1.00 1.00 14 225 0 0 0 0 0
2L3E_A - 1.00 1.00 1.00 12 228 1 0 0 1 0
2L3J_B 0.93 0.87 1.00 26 959 0 0 0 0 4
2L5Z_A - 0.68 0.67 0.75 6 103 2 0 2 0 3
2L94_A 0.97 0.94 1.00 17 340 1 0 0 1 1
2LA5_A - -0.03 0.00 0.00 0 268 7 0 7 0 7
2LBS_A - 1.00 1.00 1.00 14 193 0 0 0 0 0
2LC8_A -0.03 0.00 0.00 0 515 13 0 13 0 18
2LDL_A - 0.94 0.89 1.00 8 132 1 0 0 1 1
2LDT_A - 1.00 1.00 1.00 11 151 0 0 0 0 0
2LHP_A - 1.00 1.00 1.00 15 246 0 0 0 0 0
2LJJ_A - 1.00 1.00 1.00 7 123 3 0 0 3 0
2LK3_A - 0.94 0.89 1.00 8 92 0 0 0 0 1
2LKR_A - 0.31 0.31 0.32 9 2412 19 5 14 0 20
2LWK_A - 0.95 0.91 1.00 10 197 1 0 0 1 1
2RP0_A - 0.84 0.71 1.00 5 111 0 0 0 0 2
2RPT_A - 0.68 0.71 0.71 5 65 2 0 2 0 2
2RRC_A - 0.83 0.71 1.00 5 70 0 0 0 0 2
2WRQ_Y 0.94 0.89 1.00 8 1144 13 0 0 13 1
2WW9_F - 0.68 0.75 0.67 6 103 4 1 2 1 2
2WW9_E - -0.03 0.00 0.00 0 168 5 0 4 1 5
2WW9_D - 0.08 0.10 0.09 1 730 13 3 7 3 9
2WWQ_V 0.78 0.74 0.82 14 1187 4 1 2 1 5
2XKV_B -0.01 0.00 0.00 0 1803 32 17 15 0 11
2XQD_Y 0.95 0.90 1.00 19 1110 1 0 0 1 2
2XXA_G -0.02 0.00 0.00 0 2014 31 2 29 0 35
2Y8W_B - 1.00 1.00 1.00 6 82 1 0 0 1 0
2Y9C_V - 0.74 0.72 0.76 13 889 7 0 4 3 5
2YIE_Z - -0.02 0.00 0.00 0 591 11 5 6 0 8
2YIE_X - 0.43 0.57 0.33 4 532 10 2 6 2 3
2ZY6_A - 0.66 0.78 0.58 7 264 5 3 2 0 2
2ZZM_B 0.17 0.20 0.16 3 1339 25 4 12 9 12
2ZZN_D 0.95 0.95 0.95 21 962 1 1 0 0 1
3A2K_C 0.95 0.91 1.00 20 1088 0 0 0 0 2
3A3A_A 0.95 0.90 1.00 27 1473 0 0 0 0 3
3ADB_C - 0.72 0.61 0.87 20 1796 3 0 3 0 13
3AKZ_H 0.97 0.95 1.00 19 1108 1 0 0 1 1
3AM1_B - 0.86 0.86 0.86 25 1437 4 3 1 0 4
3AMU_B 0.77 0.79 0.75 15 1137 8 0 5 3 4
3DW4_A - 0.91 0.83 1.00 5 135 0 0 0 0 1
3G4S_9 0.12 0.15 0.11 4 2699 33 9 24 0 22
3GCA_A - 0.84 0.71 1.00 5 153 0 0 0 0 2
3GX2_A 0.61 0.57 0.67 16 1425 9 0 8 1 12
3HAY_E - 1.00 1.00 1.00 14 910 4 0 0 4 0
3HJW_D - 0.50 0.56 0.47 9 590 10 2 8 0 7
3IAB_R - 1.00 1.00 1.00 12 373 0 0 0 0 0
3ID5_D - 0.59 0.60 0.60 3 224 4 0 2 2 2
3IVN_B 0.88 0.78 1.00 18 885 0 0 0 0 5
3IWN_A 0.26 0.25 0.30 7 1449 16 2 14 0 21
3IYQ_A 0.30 0.37 0.24 19 22361 71 36 24 11 32
3IZ4_A 0.31 0.31 0.33 29 25448 65 14 45 6 66
3IZF_C 0.85 0.83 0.88 29 2607 5 0 4 1 6
3J0L_7 - -0.02 0.00 0.00 0 506 13 3 10 0 10
3J0L_h - 0.20 0.19 0.24 6 2115 19 3 16 0 26
3J0L_1 - 0.25 0.23 0.30 3 474 8 3 4 1 10
3J0L_a - 0.39 0.36 0.44 4 402 6 4 1 1 7
3J0L_g - -0.01 0.00 0.00 0 174 4 0 2 2 2
3J0L_8 - 0.74 0.57 1.00 4 72 0 0 0 0 3
3J0L_2 - 0.42 0.42 0.44 11 2225 21 1 13 7 15
3J16_L 0.98 0.95 1.00 20 1139 0 0 0 0 1
3JYV_7 -0.02 0.00 0.00 0 1092 19 4 15 0 20
3JYX_3 0.12 0.13 0.11 2 2360 20 6 10 4 13
3JYX_4 0.63 0.83 0.48 10 4735 32 9 2 21 2
3KTW_C - 0.46 0.44 0.50 11 1758 15 2 9 4 14
3LA5_A -0.02 0.00 0.00 0 938 16 0 16 0 25
3NDB_M - 0.07 0.07 0.08 3 3678 33 2 31 0 41
3NKB_B - 0.69 0.74 0.67 14 714 7 0 7 0 5
3NMU_E - 0.28 0.33 0.25 1 212 5 2 1 2 2
3NPB_A 0.62 0.54 0.71 20 2250 10 1 7 2 17
3O58_3 0.51 0.59 0.45 13 4735 28 11 5 12 9
3O58_2 0.50 0.52 0.50 16 2722 19 3 13 3 15
3OVB_D - 1.00 1.00 1.00 11 215 1 0 0 1 0
3OVS_D - 1.00 1.00 1.00 12 204 0 0 0 0 0
3P22_G - 1.00 1.00 1.00 11 301 0 0 0 0 0
3PDR_A 0.69 0.64 0.74 32 4797 13 3 8 2 18
3R4F_A - 0.98 0.95 1.00 21 885 1 0 0 1 1
3R9X_C - 1.00 1.00 1.00 8 221 2 0 0 2 0
3RKF_A 0.90 0.92 0.88 22 841 3 3 0 0 2
3SD1_A 0.13 0.14 0.15 4 1507 22 5 17 0 25
3SIU_F - 0.86 0.75 1.00 6 139 0 0 0 0 2
3SN2_B 0.95 0.92 1.00 11 143 0 0 0 0 1
3TRZ_Z - 1.00 1.00 1.00 5 87 1 0 0 1 0
3TS0_U - 1.00 1.00 1.00 6 112 1 0 0 1 0
3TS2_V - 1.00 1.00 1.00 5 103 0 0 0 0 0
3U4M_B - 0.49 0.55 0.46 12 1250 14 3 11 0 10
3UZL_B 0.24 0.31 0.20 5 1268 20 9 11 0 11
3VJR_D - 1.00 1.00 1.00 12 239 0 0 0 0 0
4A1C_3 0.29 0.30 0.31 11 2727 26 4 21 1 26
4A1C_2 0.33 0.40 0.28 8 4487 37 8 13 16 12
4A4U_A - 1.00 1.00 1.00 9 96 0 0 0 0 0
4AOB_A 0.21 0.21 0.25 6 1413 19 2 16 1 23
4ENB_A 1.00 1.00 1.00 15 457 0 0 0 0 0
4ENC_A 0.97 1.00 0.94 15 480 1 1 0 0 0

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.