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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of Multilign(20) - scored higher in this pairwise comparison

  4. Performance of NanoFolder - scored lower in this pairwise comparison

  5. Compile and download dataset for Multilign(20) & NanoFolder [.zip] - may take several seconds...


Overview

Metric Multilign(20) NanoFolder
MCC 0.607 > 0.389
Average MCC ± 95% Confidence Intervals 0.597 ± 0.464 > 0.405 ± 0.473
Sensitivity 0.614 > 0.475
Positive Predictive Value 0.608 > 0.331
Total TP 62 > 48
Total TN 9110 > 9067
Total FP 50 < 114
Total FP CONTRA 13 < 33
Total FP INCONS 27 < 64
Total FP COMP 10 < 17
Total FN 39 < 53
P-value 0.0

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Performance plots


  1. Comparison of performance of Multilign(20) and NanoFolder. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Multilign(20) and NanoFolder).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for Multilign(20) and NanoFolder. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Multilign(20) and NanoFolder).

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Performance of Multilign(20) - scored higher in this pairwise comparison

1. Total counts & total scores for Multilign(20)

Total Base Pair Counts
Total TP 62
Total TN 9110
Total FP 50
Total FP CONTRA 13
Total FP INCONS 27
Total FP COMP 10
Total FN 39
Total Scores
MCC 0.607
Average MCC ± 95% Confidence Intervals 0.597 ± 0.464
Sensitivity 0.614
Positive Predictive Value 0.608
Nr of predictions 4

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2. Individual counts for Multilign(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
4A1C_3 0.88 0.86 0.89 32 2727 6 0 4 2 5
4A1C_2 0.20 0.25 0.16 5 4485 33 9 17 7 15
4AOB_A 0.59 0.55 0.64 16 1412 10 3 6 1 13
4ENC_A 0.73 0.60 0.90 9 486 1 1 0 0 6

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Performance of NanoFolder - scored lower in this pairwise comparison

1. Total counts & total scores for NanoFolder

Total Base Pair Counts
Total TP 48
Total TN 9067
Total FP 114
Total FP CONTRA 33
Total FP INCONS 64
Total FP COMP 17
Total FN 53
Total Scores
MCC 0.389
Average MCC ± 95% Confidence Intervals 0.405 ± 0.473
Sensitivity 0.475
Positive Predictive Value 0.331
Nr of predictions 4

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2. Individual counts for NanoFolder [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
4A1C_3 0.58 0.68 0.51 25 2714 24 9 15 0 12
4A1C_2 -0.01 0.00 0.00 0 4469 61 18 29 14 20
4AOB_A 0.39 0.41 0.39 12 1406 20 4 15 1 17
4ENC_A 0.66 0.73 0.61 11 478 9 2 5 2 4

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.