CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of Multilign(seed) - scored higher in this pairwise comparison

  4. Performance of Carnac(20) - scored lower in this pairwise comparison

  5. Compile and download dataset for Multilign(seed) & Carnac(20) [.zip] - may take several seconds...


Overview

Metric Multilign(seed) Carnac(20)
MCC 0.795 > 0.663
Average MCC ± 95% Confidence Intervals 0.818 ± 0.233 > 0.554 ± 0.624
Sensitivity 0.750 > 0.500
Positive Predictive Value 0.852 < 0.893
Total TP 75 > 50
Total TN 4105 < 4137
Total FP 14 > 7
Total FP CONTRA 5 > 2
Total FP INCONS 8 > 4
Total FP COMP 1 = 1
Total FN 25 < 50
P-value 0.0

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Performance plots


  1. Comparison of performance of Multilign(seed) and Carnac(20). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Multilign(seed) and Carnac(20)).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for Multilign(seed) and Carnac(20). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Multilign(seed) and Carnac(20)).

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Performance of Multilign(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for Multilign(seed)

Total Base Pair Counts
Total TP 75
Total TN 4105
Total FP 14
Total FP CONTRA 5
Total FP INCONS 8
Total FP COMP 1
Total FN 25
Total Scores
MCC 0.795
Average MCC ± 95% Confidence Intervals 0.818 ± 0.233
Sensitivity 0.750
Positive Predictive Value 0.852
Nr of predictions 4

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2. Individual counts for Multilign(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2L94_A 0.97 0.94 1.00 17 340 0 0 0 0 1
3RKF_A 0.91 0.83 1.00 20 846 0 0 0 0 4
3SD1_A 0.66 0.66 0.68 19 1505 9 4 5 0 10
4AOB_A 0.73 0.66 0.83 19 1414 5 1 3 1 10

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Performance of Carnac(20) - scored lower in this pairwise comparison

1. Total counts & total scores for Carnac(20)

Total Base Pair Counts
Total TP 50
Total TN 4137
Total FP 7
Total FP CONTRA 2
Total FP INCONS 4
Total FP COMP 1
Total FN 50
Total Scores
MCC 0.663
Average MCC ± 95% Confidence Intervals 0.554 ± 0.624
Sensitivity 0.500
Positive Predictive Value 0.893
Nr of predictions 4

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2. Individual counts for Carnac(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2L94_A 0.00 0.00 0.00 0 357 0 0 0 0 18
3RKF_A 0.91 0.83 1.00 20 846 0 0 0 0 4
3SD1_A 0.72 0.55 0.94 16 1516 1 0 1 0 13
4AOB_A 0.59 0.48 0.74 14 1418 6 2 3 1 15

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.