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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of Multilign(seed) - scored higher in this pairwise comparison

  4. Performance of ProbKnot - scored lower in this pairwise comparison

  5. Compile and download dataset for Multilign(seed) & ProbKnot [.zip] - may take several seconds...


Overview

Metric Multilign(seed) ProbKnot
MCC 0.683 > 0.641
Average MCC ± 95% Confidence Intervals 0.649 ± 0.495 > 0.619 ± 0.493
Sensitivity 0.636 = 0.636
Positive Predictive Value 0.750 > 0.664
Total TP 75 = 75
Total TN 4621 > 4608
Total FP 26 < 40
Total FP CONTRA 7 < 15
Total FP INCONS 18 < 23
Total FP COMP 1 < 2
Total FN 43 = 43
P-value 0.0

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Performance plots


  1. Comparison of performance of Multilign(seed) and ProbKnot. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Multilign(seed) and ProbKnot).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for Multilign(seed) and ProbKnot. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Multilign(seed) and ProbKnot).

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Performance of Multilign(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for Multilign(seed)

Total Base Pair Counts
Total TP 75
Total TN 4621
Total FP 26
Total FP CONTRA 7
Total FP INCONS 18
Total FP COMP 1
Total FN 43
Total Scores
MCC 0.683
Average MCC ± 95% Confidence Intervals 0.649 ± 0.495
Sensitivity 0.636
Positive Predictive Value 0.750
Nr of predictions 5

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2. Individual counts for Multilign(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2L94_A 0.97 0.94 1.00 17 340 0 0 0 0 1
2LC8_A -0.03 0.00 0.00 0 516 12 2 10 0 18
3RKF_A 0.91 0.83 1.00 20 846 0 0 0 0 4
3SD1_A 0.66 0.66 0.68 19 1505 9 4 5 0 10
4AOB_A 0.73 0.66 0.83 19 1414 5 1 3 1 10

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Performance of ProbKnot - scored lower in this pairwise comparison

1. Total counts & total scores for ProbKnot

Total Base Pair Counts
Total TP 75
Total TN 4608
Total FP 40
Total FP CONTRA 15
Total FP INCONS 23
Total FP COMP 2
Total FN 43
Total Scores
MCC 0.641
Average MCC ± 95% Confidence Intervals 0.619 ± 0.493
Sensitivity 0.636
Positive Predictive Value 0.664
Nr of predictions 5

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2. Individual counts for ProbKnot [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2L94_A 1.00 1.00 1.00 18 339 1 0 0 1 0
2LC8_A -0.03 0.00 0.00 0 513 15 3 12 0 18
3RKF_A 0.87 0.83 0.91 20 844 2 2 0 0 4
3SD1_A 0.66 0.69 0.65 20 1502 11 6 5 0 9
4AOB_A 0.60 0.59 0.63 17 1410 11 4 6 1 12

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.