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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of Multilign(seed) - scored higher in this pairwise comparison

  4. Performance of RNAalifold(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for Multilign(seed) & RNAalifold(seed) [.zip] - may take several seconds...


Overview

Metric Multilign(seed) RNAalifold(seed)
MCC 0.683 > 0.620
Average MCC ± 95% Confidence Intervals 0.649 ± 0.495 > 0.567 ± 0.431
Sensitivity 0.636 > 0.517
Positive Predictive Value 0.750 < 0.763
Total TP 75 > 61
Total TN 4621 < 4641
Total FP 26 > 22
Total FP CONTRA 7 > 3
Total FP INCONS 18 > 16
Total FP COMP 1 < 3
Total FN 43 < 57
P-value 0.0

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Performance plots


  1. Comparison of performance of Multilign(seed) and RNAalifold(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Multilign(seed) and RNAalifold(seed)).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for Multilign(seed) and RNAalifold(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Multilign(seed) and RNAalifold(seed)).

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Performance of Multilign(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for Multilign(seed)

Total Base Pair Counts
Total TP 75
Total TN 4621
Total FP 26
Total FP CONTRA 7
Total FP INCONS 18
Total FP COMP 1
Total FN 43
Total Scores
MCC 0.683
Average MCC ± 95% Confidence Intervals 0.649 ± 0.495
Sensitivity 0.636
Positive Predictive Value 0.750
Nr of predictions 5

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2. Individual counts for Multilign(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2L94_A 0.97 0.94 1.00 17 340 0 0 0 0 1
2LC8_A -0.03 0.00 0.00 0 516 12 2 10 0 18
3RKF_A 0.91 0.83 1.00 20 846 0 0 0 0 4
3SD1_A 0.66 0.66 0.68 19 1505 9 4 5 0 10
4AOB_A 0.73 0.66 0.83 19 1414 5 1 3 1 10

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Performance of RNAalifold(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for RNAalifold(seed)

Total Base Pair Counts
Total TP 61
Total TN 4641
Total FP 22
Total FP CONTRA 3
Total FP INCONS 16
Total FP COMP 3
Total FN 57
Total Scores
MCC 0.620
Average MCC ± 95% Confidence Intervals 0.567 ± 0.431
Sensitivity 0.517
Positive Predictive Value 0.763
Nr of predictions 5

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2. Individual counts for RNAalifold(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2L94_A 0.57 0.39 0.88 7 349 2 0 1 1 11
2LC8_A -0.03 0.00 0.00 0 516 12 0 12 0 18
3RKF_A 0.74 0.67 0.84 16 847 3 1 2 0 8
3SD1_A 0.70 0.59 0.85 17 1513 3 2 1 0 12
4AOB_A 0.85 0.72 1.00 21 1416 2 0 0 2 8

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.