CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of Multilign(seed) - scored higher in this pairwise comparison

  4. Performance of RNAwolf - scored lower in this pairwise comparison

  5. Compile and download dataset for Multilign(seed) & RNAwolf [.zip] - may take several seconds...


Overview

Metric Multilign(seed) RNAwolf
MCC 0.629 > 0.552
Average MCC ± 95% Confidence Intervals 0.569 ± 0.654 > 0.560 ± 0.412
Sensitivity 0.580 > 0.530
Positive Predictive Value 0.699 > 0.596
Total TP 58 > 53
Total TN 4281 > 4275
Total FP 26 < 37
Total FP CONTRA 7 > 4
Total FP INCONS 18 < 32
Total FP COMP 1 = 1
Total FN 42 < 47
P-value 0.0

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Performance plots


  1. Comparison of performance of Multilign(seed) and RNAwolf. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Multilign(seed) and RNAwolf).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for Multilign(seed) and RNAwolf. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Multilign(seed) and RNAwolf).

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Performance of Multilign(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for Multilign(seed)

Total Base Pair Counts
Total TP 58
Total TN 4281
Total FP 26
Total FP CONTRA 7
Total FP INCONS 18
Total FP COMP 1
Total FN 42
Total Scores
MCC 0.629
Average MCC ± 95% Confidence Intervals 0.569 ± 0.654
Sensitivity 0.580
Positive Predictive Value 0.699
Nr of predictions 4

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2. Individual counts for Multilign(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A -0.03 0.00 0.00 0 516 12 2 10 0 18
3RKF_A 0.91 0.83 1.00 20 846 0 0 0 0 4
3SD1_A 0.66 0.66 0.68 19 1505 9 4 5 0 10
4AOB_A 0.73 0.66 0.83 19 1414 5 1 3 1 10

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Performance of RNAwolf - scored lower in this pairwise comparison

1. Total counts & total scores for RNAwolf

Total Base Pair Counts
Total TP 53
Total TN 4275
Total FP 37
Total FP CONTRA 4
Total FP INCONS 32
Total FP COMP 1
Total FN 47
Total Scores
MCC 0.552
Average MCC ± 95% Confidence Intervals 0.560 ± 0.412
Sensitivity 0.530
Positive Predictive Value 0.596
Nr of predictions 4

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2. Individual counts for RNAwolf [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A 0.52 0.50 0.56 9 512 7 0 7 0 9
3RKF_A 0.89 0.83 0.95 20 845 1 0 1 0 4
3SD1_A 0.58 0.59 0.59 17 1504 12 2 10 0 12
4AOB_A 0.26 0.24 0.30 7 1414 17 2 14 1 22

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.