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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of Multilign(seed) - scored higher in this pairwise comparison

  4. Performance of UNAFold - scored lower in this pairwise comparison

  5. Compile and download dataset for Multilign(seed) & UNAFold [.zip] - may take several seconds...


Overview

Metric Multilign(seed) UNAFold
MCC 0.683 > 0.674
Average MCC ± 95% Confidence Intervals 0.649 ± 0.495 < 0.649 ± 0.508
Sensitivity 0.636 < 0.653
Positive Predictive Value 0.750 > 0.713
Total TP 75 < 77
Total TN 4621 > 4613
Total FP 26 < 33
Total FP CONTRA 7 < 11
Total FP INCONS 18 < 20
Total FP COMP 1 < 2
Total FN 43 > 41
P-value 0.0

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Performance plots


  1. Comparison of performance of Multilign(seed) and UNAFold. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Multilign(seed) and UNAFold).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for Multilign(seed) and UNAFold. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Multilign(seed) and UNAFold).

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Performance of Multilign(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for Multilign(seed)

Total Base Pair Counts
Total TP 75
Total TN 4621
Total FP 26
Total FP CONTRA 7
Total FP INCONS 18
Total FP COMP 1
Total FN 43
Total Scores
MCC 0.683
Average MCC ± 95% Confidence Intervals 0.649 ± 0.495
Sensitivity 0.636
Positive Predictive Value 0.750
Nr of predictions 5

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2. Individual counts for Multilign(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2L94_A 0.97 0.94 1.00 17 340 0 0 0 0 1
2LC8_A -0.03 0.00 0.00 0 516 12 2 10 0 18
3RKF_A 0.91 0.83 1.00 20 846 0 0 0 0 4
3SD1_A 0.66 0.66 0.68 19 1505 9 4 5 0 10
4AOB_A 0.73 0.66 0.83 19 1414 5 1 3 1 10

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Performance of UNAFold - scored lower in this pairwise comparison

1. Total counts & total scores for UNAFold

Total Base Pair Counts
Total TP 77
Total TN 4613
Total FP 33
Total FP CONTRA 11
Total FP INCONS 20
Total FP COMP 2
Total FN 41
Total Scores
MCC 0.674
Average MCC ± 95% Confidence Intervals 0.649 ± 0.508
Sensitivity 0.653
Positive Predictive Value 0.713
Nr of predictions 5

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2. Individual counts for UNAFold [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2L94_A 1.00 1.00 1.00 18 339 1 0 0 1 0
2LC8_A -0.03 0.00 0.00 0 513 15 3 12 0 18
3RKF_A 0.91 0.83 1.00 20 846 0 0 0 0 4
3SD1_A 0.77 0.76 0.79 22 1505 6 4 2 0 7
4AOB_A 0.60 0.59 0.63 17 1410 11 4 6 1 12

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.