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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of Murlet(20) - scored higher in this pairwise comparison

  4. Performance of NanoFolder - scored lower in this pairwise comparison

  5. Compile and download dataset for Murlet(20) & NanoFolder [.zip] - may take several seconds...


Overview

Metric Murlet(20) NanoFolder
MCC 0.609 > 0.389
Average MCC ± 95% Confidence Intervals 0.595 ± 0.443 > 0.405 ± 0.473
Sensitivity 0.535 > 0.475
Positive Predictive Value 0.701 > 0.331
Total TP 54 > 48
Total TN 9135 > 9067
Total FP 31 < 114
Total FP CONTRA 5 < 33
Total FP INCONS 18 < 64
Total FP COMP 8 < 17
Total FN 47 < 53
P-value 0.0

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Performance plots


  1. Comparison of performance of Murlet(20) and NanoFolder. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Murlet(20) and NanoFolder).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for Murlet(20) and NanoFolder. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Murlet(20) and NanoFolder).

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Performance of Murlet(20) - scored higher in this pairwise comparison

1. Total counts & total scores for Murlet(20)

Total Base Pair Counts
Total TP 54
Total TN 9135
Total FP 31
Total FP CONTRA 5
Total FP INCONS 18
Total FP COMP 8
Total FN 47
Total Scores
MCC 0.609
Average MCC ± 95% Confidence Intervals 0.595 ± 0.443
Sensitivity 0.535
Positive Predictive Value 0.701
Nr of predictions 4

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2. Individual counts for Murlet(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
4A1C_2 0.22 0.25 0.20 5 4491 24 5 15 4 15
4A1C_3 0.72 0.59 0.88 22 2738 4 0 3 1 15
4AOB_A 0.87 0.76 1.00 22 1415 3 0 0 3 7
4ENC_A 0.57 0.33 1.00 5 491 0 0 0 0 10

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Performance of NanoFolder - scored lower in this pairwise comparison

1. Total counts & total scores for NanoFolder

Total Base Pair Counts
Total TP 48
Total TN 9067
Total FP 114
Total FP CONTRA 33
Total FP INCONS 64
Total FP COMP 17
Total FN 53
Total Scores
MCC 0.389
Average MCC ± 95% Confidence Intervals 0.405 ± 0.473
Sensitivity 0.475
Positive Predictive Value 0.331
Nr of predictions 4

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2. Individual counts for NanoFolder [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
4A1C_2 -0.01 0.00 0.00 0 4469 61 18 29 14 20
4A1C_3 0.58 0.68 0.51 25 2714 24 9 15 0 12
4AOB_A 0.39 0.41 0.39 12 1406 20 4 15 1 17
4ENC_A 0.66 0.73 0.61 11 478 9 2 5 2 4

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.