CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of NanoFolder - scored higher in this pairwise comparison

  4. Performance of Carnac(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for NanoFolder & Carnac(seed) [.zip] - may take several seconds...


Overview

Metric NanoFolder Carnac(seed)
MCC 0.410 > 0.182
Average MCC ± 95% Confidence Intervals 0.431 ± 0.328 > 0.093 ± 0.258
Sensitivity 0.496 > 0.034
Positive Predictive Value 0.353 < 1.000
Total TP 59 > 4
Total TN 9573 < 9736
Total FP 125 > 0
Total FP CONTRA 34 > 0
Total FP INCONS 74 > 0
Total FP COMP 17 > 0
Total FN 60 < 115
P-value 0.0

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Performance plots


  1. Comparison of performance of NanoFolder and Carnac(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for NanoFolder and Carnac(seed)).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for NanoFolder and Carnac(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for NanoFolder and Carnac(seed)).

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Performance of NanoFolder - scored higher in this pairwise comparison

1. Total counts & total scores for NanoFolder

Total Base Pair Counts
Total TP 59
Total TN 9573
Total FP 125
Total FP CONTRA 34
Total FP INCONS 74
Total FP COMP 17
Total FN 60
Total Scores
MCC 0.410
Average MCC ± 95% Confidence Intervals 0.431 ± 0.328
Sensitivity 0.496
Positive Predictive Value 0.353
Nr of predictions 5

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2. Individual counts for NanoFolder [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A 0.54 0.61 0.50 11 506 11 1 10 0 7
4A1C_2 -0.01 0.00 0.00 0 4469 61 18 29 14 20
4A1C_3 0.58 0.68 0.51 25 2714 24 9 15 0 12
4AOB_A 0.39 0.41 0.39 12 1406 20 4 15 1 17
4ENC_A 0.66 0.73 0.61 11 478 9 2 5 2 4

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Performance of Carnac(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for Carnac(seed)

Total Base Pair Counts
Total TP 4
Total TN 9736
Total FP 0
Total FP CONTRA 0
Total FP INCONS 0
Total FP COMP 0
Total FN 115
Total Scores
MCC 0.182
Average MCC ± 95% Confidence Intervals 0.093 ± 0.258
Sensitivity 0.034
Positive Predictive Value 1.000
Nr of predictions 5

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2. Individual counts for Carnac(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A 0.47 0.22 1.00 4 524 0 0 0 0 14
4A1C_2 0.00 0.00 0.00 0 4516 0 0 0 0 20
4A1C_3 0.00 0.00 0.00 0 2763 0 0 0 0 37
4AOB_A 0.00 0.00 0.00 0 1437 0 0 0 0 29
4ENC_A 0.00 0.00 0.00 0 496 0 0 0 0 15

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.