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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of PETfold_pre2.0(20) - scored higher in this pairwise comparison

  4. Performance of CentroidHomfold‑LAST - scored lower in this pairwise comparison

  5. Compile and download dataset for PETfold_pre2.0(20) & CentroidHomfold‑LAST [.zip] - may take several seconds...


Overview

Metric PETfold_pre2.0(20) CentroidHomfold‑LAST
MCC 0.747 > 0.715
Average MCC ± 95% Confidence Intervals 0.683 ± 0.357 < 0.720 ± 0.334
Sensitivity 0.707 > 0.664
Positive Predictive Value 0.796 > 0.778
Total TP 82 > 77
Total TN 9581 < 9585
Total FP 34 < 37
Total FP CONTRA 2 < 8
Total FP INCONS 19 > 14
Total FP COMP 13 < 15
Total FN 34 < 39
P-value 0.0

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Performance plots


  1. Comparison of performance of PETfold_pre2.0(20) and CentroidHomfold-LAST. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for PETfold_pre2.0(20) and CentroidHomfold‑LAST).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for PETfold_pre2.0(20) and CentroidHomfold-LAST. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for PETfold_pre2.0(20) and CentroidHomfold‑LAST).

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Performance of PETfold_pre2.0(20) - scored higher in this pairwise comparison

1. Total counts & total scores for PETfold_pre2.0(20)

Total Base Pair Counts
Total TP 82
Total TN 9581
Total FP 34
Total FP CONTRA 2
Total FP INCONS 19
Total FP COMP 13
Total FN 34
Total Scores
MCC 0.747
Average MCC ± 95% Confidence Intervals 0.683 ± 0.357
Sensitivity 0.707
Positive Predictive Value 0.796
Nr of predictions 5

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2. Individual counts for PETfold_pre2.0(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
4A1C_2 0.25 0.25 0.25 5 4496 25 2 13 10 15
4A1C_3 1.00 1.00 1.00 37 2726 1 0 0 1 0
4AOB_A 0.87 0.83 0.92 24 1411 4 0 2 2 5
4ENB_A 0.68 0.53 0.89 8 463 1 0 1 0 7
4ENC_A 0.61 0.53 0.73 8 485 3 0 3 0 7

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Performance of CentroidHomfold‑LAST - scored lower in this pairwise comparison

1. Total counts & total scores for CentroidHomfold‑LAST

Total Base Pair Counts
Total TP 77
Total TN 9585
Total FP 37
Total FP CONTRA 8
Total FP INCONS 14
Total FP COMP 15
Total FN 39
Total Scores
MCC 0.715
Average MCC ± 95% Confidence Intervals 0.720 ± 0.334
Sensitivity 0.664
Positive Predictive Value 0.778
Nr of predictions 5

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2. Individual counts for CentroidHomfold‑LAST [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
4A1C_2 0.24 0.25 0.24 5 4495 29 8 8 13 15
4A1C_3 0.80 0.78 0.83 29 2728 7 0 6 1 8
4AOB_A 0.85 0.72 1.00 21 1416 1 0 0 1 8
4ENB_A 0.85 0.73 1.00 11 461 0 0 0 0 4
4ENC_A 0.85 0.73 1.00 11 485 0 0 0 0 4

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.