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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of PETfold_pre2.0(20) - scored higher in this pairwise comparison

  4. Performance of MCFold - scored lower in this pairwise comparison

  5. Compile and download dataset for PETfold_pre2.0(20) & MCFold [.zip] - may take several seconds...


Overview

Metric PETfold_pre2.0(20) MCFold
MCC 0.706 > 0.566
Average MCC ± 95% Confidence Intervals 0.635 ± 0.492 > 0.541 ± 0.529
Sensitivity 0.667 > 0.609
Positive Predictive Value 0.753 > 0.535
Total TP 58 > 53
Total TN 8170 > 8148
Total FP 30 < 69
Total FP CONTRA 2 < 12
Total FP INCONS 17 < 34
Total FP COMP 11 < 23
Total FN 29 < 34
P-value 0.0

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Performance plots


  1. Comparison of performance of PETfold_pre2.0(20) and MCFold. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for PETfold_pre2.0(20) and MCFold).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for PETfold_pre2.0(20) and MCFold. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for PETfold_pre2.0(20) and MCFold).

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Performance of PETfold_pre2.0(20) - scored higher in this pairwise comparison

1. Total counts & total scores for PETfold_pre2.0(20)

Total Base Pair Counts
Total TP 58
Total TN 8170
Total FP 30
Total FP CONTRA 2
Total FP INCONS 17
Total FP COMP 11
Total FN 29
Total Scores
MCC 0.706
Average MCC ± 95% Confidence Intervals 0.635 ± 0.492
Sensitivity 0.667
Positive Predictive Value 0.753
Nr of predictions 4

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2. Individual counts for PETfold_pre2.0(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
4A1C_2 0.25 0.25 0.25 5 4496 25 2 13 10 15
4A1C_3 1.00 1.00 1.00 37 2726 1 0 0 1 0
4ENB_A 0.68 0.53 0.89 8 463 1 0 1 0 7
4ENC_A 0.61 0.53 0.73 8 485 3 0 3 0 7

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Performance of MCFold - scored lower in this pairwise comparison

1. Total counts & total scores for MCFold

Total Base Pair Counts
Total TP 53
Total TN 8148
Total FP 69
Total FP CONTRA 12
Total FP INCONS 34
Total FP COMP 23
Total FN 34
Total Scores
MCC 0.566
Average MCC ± 95% Confidence Intervals 0.541 ± 0.529
Sensitivity 0.609
Positive Predictive Value 0.535
Nr of predictions 4

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2. Individual counts for MCFold [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
4A1C_2 0.18 0.25 0.14 5 4480 45 12 19 14 15
4A1C_3 0.86 0.86 0.86 32 2726 9 0 5 4 5
4ENB_A 0.78 0.73 0.85 11 459 4 0 2 2 4
4ENC_A 0.34 0.33 0.38 5 483 11 0 8 3 10

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.