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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of PETfold_pre2.0(seed) - scored higher in this pairwise comparison

  4. Performance of CentroidAlifold(20) - scored lower in this pairwise comparison

  5. Compile and download dataset for PETfold_pre2.0(seed) & CentroidAlifold(20) [.zip] - may take several seconds...


Overview

Metric PETfold_pre2.0(seed) CentroidAlifold(20)
MCC 0.835 > 0.779
Average MCC ± 95% Confidence Intervals 0.773 ± 0.205 > 0.720 ± 0.295
Sensitivity 0.784 > 0.672
Positive Predictive Value 0.892 < 0.907
Total TP 91 > 78
Total TN 9582 < 9598
Total FP 28 > 14
Total FP CONTRA 3 = 3
Total FP INCONS 8 > 5
Total FP COMP 17 > 6
Total FN 25 < 38
P-value 0.0

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Performance plots


  1. Comparison of performance of PETfold_pre2.0(seed) and CentroidAlifold(20). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for PETfold_pre2.0(seed) and CentroidAlifold(20)).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for PETfold_pre2.0(seed) and CentroidAlifold(20). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for PETfold_pre2.0(seed) and CentroidAlifold(20)).

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Performance of PETfold_pre2.0(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for PETfold_pre2.0(seed)

Total Base Pair Counts
Total TP 91
Total TN 9582
Total FP 28
Total FP CONTRA 3
Total FP INCONS 8
Total FP COMP 17
Total FN 25
Total Scores
MCC 0.835
Average MCC ± 95% Confidence Intervals 0.773 ± 0.205
Sensitivity 0.784
Positive Predictive Value 0.892
Nr of predictions 5

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2. Individual counts for PETfold_pre2.0(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
4A1C_3 1.00 1.00 1.00 37 2726 2 0 0 2 0
4A1C_2 0.79 0.75 0.83 15 4498 12 1 2 9 5
4AOB_A 0.85 0.79 0.92 23 1412 4 0 2 2 6
4ENB_A 0.61 0.53 0.73 8 461 5 1 2 2 7
4ENC_A 0.61 0.53 0.73 8 485 5 1 2 2 7

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Performance of CentroidAlifold(20) - scored lower in this pairwise comparison

1. Total counts & total scores for CentroidAlifold(20)

Total Base Pair Counts
Total TP 78
Total TN 9598
Total FP 14
Total FP CONTRA 3
Total FP INCONS 5
Total FP COMP 6
Total FN 38
Total Scores
MCC 0.779
Average MCC ± 95% Confidence Intervals 0.720 ± 0.295
Sensitivity 0.672
Positive Predictive Value 0.907
Nr of predictions 5

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2. Individual counts for CentroidAlifold(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
4A1C_3 0.93 0.92 0.94 34 2727 4 0 2 2 3
4A1C_2 0.33 0.25 0.45 5 4505 8 3 3 2 15
4AOB_A 0.89 0.79 1.00 23 1414 2 0 0 2 6
4ENB_A 0.77 0.60 1.00 9 463 0 0 0 0 6
4ENC_A 0.68 0.47 1.00 7 489 0 0 0 0 8

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.