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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of PETfold_pre2.0(seed) - scored higher in this pairwise comparison

  4. Performance of Multilign(20) - scored lower in this pairwise comparison

  5. Compile and download dataset for PETfold_pre2.0(seed) & Multilign(20) [.zip] - may take several seconds...


Overview

Metric PETfold_pre2.0(seed) Multilign(20)
MCC 0.835 > 0.583
Average MCC ± 95% Confidence Intervals 0.773 ± 0.205 > 0.556 ± 0.333
Sensitivity 0.784 > 0.578
Positive Predictive Value 0.892 > 0.598
Total TP 91 > 67
Total TN 9582 > 9572
Total FP 28 < 56
Total FP CONTRA 3 < 13
Total FP INCONS 8 < 32
Total FP COMP 17 > 11
Total FN 25 < 49
P-value 0.0

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Performance plots


  1. Comparison of performance of PETfold_pre2.0(seed) and Multilign(20). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for PETfold_pre2.0(seed) and Multilign(20)).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for PETfold_pre2.0(seed) and Multilign(20). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for PETfold_pre2.0(seed) and Multilign(20)).

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Performance of PETfold_pre2.0(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for PETfold_pre2.0(seed)

Total Base Pair Counts
Total TP 91
Total TN 9582
Total FP 28
Total FP CONTRA 3
Total FP INCONS 8
Total FP COMP 17
Total FN 25
Total Scores
MCC 0.835
Average MCC ± 95% Confidence Intervals 0.773 ± 0.205
Sensitivity 0.784
Positive Predictive Value 0.892
Nr of predictions 5

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2. Individual counts for PETfold_pre2.0(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
4A1C_2 0.79 0.75 0.83 15 4498 12 1 2 9 5
4A1C_3 1.00 1.00 1.00 37 2726 2 0 0 2 0
4AOB_A 0.85 0.79 0.92 23 1412 4 0 2 2 6
4ENB_A 0.61 0.53 0.73 8 461 5 1 2 2 7
4ENC_A 0.61 0.53 0.73 8 485 5 1 2 2 7

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Performance of Multilign(20) - scored lower in this pairwise comparison

1. Total counts & total scores for Multilign(20)

Total Base Pair Counts
Total TP 67
Total TN 9572
Total FP 56
Total FP CONTRA 13
Total FP INCONS 32
Total FP COMP 11
Total FN 49
Total Scores
MCC 0.583
Average MCC ± 95% Confidence Intervals 0.556 ± 0.333
Sensitivity 0.578
Positive Predictive Value 0.598
Nr of predictions 5

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2. Individual counts for Multilign(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
4A1C_2 0.20 0.25 0.16 5 4485 33 9 17 7 15
4A1C_3 0.88 0.86 0.89 32 2727 6 0 4 2 5
4AOB_A 0.59 0.55 0.64 16 1412 10 3 6 1 13
4ENB_A 0.39 0.33 0.50 5 462 6 0 5 1 10
4ENC_A 0.73 0.60 0.90 9 486 1 1 0 0 6

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.