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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of PPfold(20) - scored higher in this pairwise comparison

  4. Performance of RNASLOpt - scored lower in this pairwise comparison

  5. Compile and download dataset for PPfold(20) & RNASLOpt [.zip] - may take several seconds...


Overview

Metric PPfold(20) RNASLOpt
MCC 0.732 > 0.560
Average MCC ± 95% Confidence Intervals 0.669 ± 0.324 > 0.598 ± 0.334
Sensitivity 0.672 > 0.543
Positive Predictive Value 0.804 > 0.589
Total TP 78 > 63
Total TN 9587 > 9577
Total FP 25 < 54
Total FP CONTRA 1 < 17
Total FP INCONS 18 < 27
Total FP COMP 6 < 10
Total FN 38 < 53
P-value 0.0

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Performance plots


  1. Comparison of performance of PPfold(20) and RNASLOpt. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for PPfold(20) and RNASLOpt).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for PPfold(20) and RNASLOpt. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for PPfold(20) and RNASLOpt).

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Performance of PPfold(20) - scored higher in this pairwise comparison

1. Total counts & total scores for PPfold(20)

Total Base Pair Counts
Total TP 78
Total TN 9587
Total FP 25
Total FP CONTRA 1
Total FP INCONS 18
Total FP COMP 6
Total FN 38
Total Scores
MCC 0.732
Average MCC ± 95% Confidence Intervals 0.669 ± 0.324
Sensitivity 0.672
Positive Predictive Value 0.804
Nr of predictions 5

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2. Individual counts for PPfold(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
4A1C_3 0.93 0.92 0.94 34 2727 2 0 2 0 3
4A1C_2 0.27 0.25 0.29 5 4499 16 1 11 4 15
4AOB_A 0.87 0.83 0.92 24 1411 4 0 2 2 5
4ENB_A 0.63 0.47 0.88 7 464 1 0 1 0 8
4ENC_A 0.64 0.53 0.80 8 486 2 0 2 0 7

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Performance of RNASLOpt - scored lower in this pairwise comparison

1. Total counts & total scores for RNASLOpt

Total Base Pair Counts
Total TP 63
Total TN 9577
Total FP 54
Total FP CONTRA 17
Total FP INCONS 27
Total FP COMP 10
Total FN 53
Total Scores
MCC 0.560
Average MCC ± 95% Confidence Intervals 0.598 ± 0.334
Sensitivity 0.543
Positive Predictive Value 0.589
Nr of predictions 5

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2. Individual counts for RNASLOpt [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
4A1C_3 0.79 0.73 0.87 27 2732 5 0 4 1 10
4A1C_2 0.30 0.40 0.24 8 4482 35 13 13 9 12
4AOB_A 0.31 0.28 0.38 8 1416 13 3 10 0 21
4ENB_A 0.85 0.73 1.00 11 461 0 0 0 0 4
4ENC_A 0.73 0.60 0.90 9 486 1 1 0 0 6

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.